|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
We report on a 55-year-old woman in whom AIH developed during the convalescence period of serologically proven acute viral hepatitis type A. HLA class II DRB1*0401, which was reported to be associated with AIH with a moderate coarse and late appearance in life, was found in this patient.
|
10548341 |
1999 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, our study does not support the association of HLA-DRB1*04:04:01 with the susceptibility to AIH in Mexican population.
|
31570816 |
2019 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Among the HLA DRB1 alleles, DRB1*0301 (20% vs 6.19%; P = 0.03), DRB1*1301 (15% vs 2.65%; P = 0.01), DRB1*14 (30% vs 11.5%; P = 0.02) and DRB1*1501 (40% vs 22.12%; P = 0.08) were increased in AIH patients when compared with the controls.
|
15683420 |
2005 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The detailed internal replication and parallel analyses allowed the observation of two of eight AIH cases carrying a rare allele genotype for a previously described AIH-associated gene (FTCD), plus multiple occurrences of known HLA-DRB1 alleles associated with AIH (HLA-DRB1-03:01:01, 13:01:01 and 7:01:01).
|
29995946 |
2018 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
In PCR-RFLP typing, the frequency of DRB1*0405 was significantly higher in autoimmune hepatitis than in controls.
|
1354193 |
1992 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Susceptibility for type 1 autoimmune hepatitis has been associated with the major histocompatibility alleles DRB1*0301, DRB3*0101, DRB1*0401, and DRB4*0103, whereas the DRB1*1501 allele may protect from the disease.
|
9021941 |
1997 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The DRB1*04:05-DQB1*04:01 haplotype was significantly associated with AIH susceptibility (30% vs. 11%, P = 1.2×10(-10); odds ratio [OR] = 3.51) and correlated with elevated serum IgG (3042 vs. 2606 mg/dL, P = 0.041) and anti-smooth muscle antigen positivity (77% vs. 34%, P = 0.000006).
|
24956105 |
2014 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
By high-resolution analysis, the frequencies of DRB1 *0405 and DQB1 *0401 were significantly increased in patients with AIH (P = 0.0001, OR = 3.74; P = 0.00006, OR = 3.95, respectively).
|
18022727 |
2008 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, HLA DRB1*13 may be a genetic risk factor for some white North American patients with type 1 autoimmune hepatitis.
|
17510796 |
2008 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The presence of HLA alleles B*08:01, C*07:01, DRB1*03:01, DQB1*02:01 and possibly A*01:01 enhances the risk of AIH (type 1) in Spanish patients.
|
27206238 |
2016 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Comparison of DRB1*13- and DRB1*03-positive subjects revealed that the former alleles conferred susceptibility to younger patients with AIH type 1.
|
10406258 |
1999 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
The predisposing association of DRB1*04:01 (P = 0.0006, corrected P [Pc] = 0.0193, odds ratio [OR] 2.97, 95% confidence interval [CI] 1.62-5.43), DRB1*04:05 (P = 1.89×10-21, Pc = 5.86×10-20, OR 3.41, 95% CI 2.65-4.38), and DQB1*04:01 (P = 4.66×10-18, Pc = 6.99×10-17, OR 3.89, 95% CI 2.84-5.33) and the protective association of DRB1*13:02 (P = 0.0003, Pc = 0.0080, OR 0.48, 95% CI 0.32-0.72) with Japanese type 1 AIH were observed.
|
29088299 |
2017 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
HLA-DRB1 gene is the major genetic determinant in HLA class II region for children with type 1 AIH.
|
15158329 |
2004 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
A significant association of autoimmune hepatitis with DRB1*0404 was found, (chi2Y=19.95, pc=0.002, RR=7.71), suggesting the presence of a susceptibility gene located at the DRB1 locus.
|
9672174 |
1998 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Although the HLA-DRB1*0405 allele is associated with type 1 AIH in Japanese, the exact genetic etiology of AIH remains undefined.
|
17020818 |
2007 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Logistic regression analysis revealed that the HLA-DRB1*04:05 allele (P < 0.001, OR = 4.61) and rs9277534 (P = 0.004, OR = 1.67) were independently associated with AIH susceptibility. rs9277534G in the HLA-DP gene is an eQTL that affects gene expression and may contribute to AIH susceptibility.
|
30093645 |
2018 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, DRB1(∗)11 was less frequent in AIH patients.
|
26780502 |
2016 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
Human leucocyte antigen typing revealed DRB1*03 heterozygosity, which has been associated with the occurrence of both autoimmune hepatitis and type 1 diabetes.
|
22797478 |
2010 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The frequency of deleterious alleles in TNFAIP3 was higher in the AIH subset without the DRB1 risk alleles than that with (P = 0.0052, OR 5.10, 95%CI 1.55-16.74).
|
31138864 |
2019 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genetic susceptibility to autoimmune hepatitis is strongly associated with HLA-DRB1 alleles.
|
20933106 |
2011 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
According to the univariate analysis, overlapping features of autoimmune hepatitis (rPSC in 5/5, <i>P</i> ≤ 0.05) and <i>HLA-DRB1*07</i> in the donor (rPSC in 10/15, <i>P</i> ≤ 0.05) represent other potential risk factors for rPSC, while the <i>HLA-DRB1*04</i> (rPSC in 0/6, <i>P</i> ≤ 0.05), <i>HLA-DQB1*03</i> (rPSC in 1/11, <i>P</i> ≤ 0.05), and <i>HLA-DQB1*07</i> (rPSC in 0/7, <i>P</i> ≤ 0.05) recipient alleles may have protective roles.
|
30487703 |
2018 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study therefore reveals that different HLA-DRB1 allotypes confer susceptibility to AH in children and adults and raises the possibility that PAH and AAH may be triggered by different factors.
|
10573514 |
1999 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
DRB1*0301 and DRB1*0401 are confirmed as the principal susceptibility alleles for type 1 autoimmune hepatitis, and these data support the hypothesis that a lysine residue at position 71 of the DR beta-polypeptide chain may be the major risk factor.
|
9178696 |
1997 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the HLA-DRB1*03:01 and HLA-DRB1*04:01 alleles are both independently associated with the aggregate diagnostic IAIHG score in type-1 AIH patients, but are not essential for AIH development.
|
25611558 |
2015 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
On the other hand, frequencies of A32 and DRB1*04 were high among patients with unclassified autoimmune hepatitis.
|
21480110 |
2011 |