Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.310 Biomarker disease GENOMICS_ENGLAND Notably, several germline mutations were found matching between paired FNMTC patients from the same family, including APC L292F and A2778S, BRAF D22N, MSH6 G355S and A36V, MSH2 L719F, MEN1 G508D, BRCA1 SS955S, BRCA2 G2508S, and a GNAS inframe insertion. 26530882 2015
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.310 GeneticVariation disease BEFREE Allelic loss of susceptibility loci and the occurrence of BRAF and RAS mutations in patients with familial non-medullary thyroid cancer. 21826673 2012
Entrez Id: 4221
Gene Symbol: MEN1
MEN1 		0.300 Biomarker disease GENOMICS_ENGLAND Notably, several germline mutations were found matching between paired FNMTC patients from the same family, including APC L292F and A2778S, BRAF D22N, MSH6 G355S and A36V, MSH2 L719F, MEN1 G508D, BRCA1 SS955S, BRCA2 G2508S, and a GNAS inframe insertion. 26530882 2015
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		0.300 Biomarker disease GENOMICS_ENGLAND Notably, several germline mutations were found matching between paired FNMTC patients from the same family, including APC L292F and A2778S, BRAF D22N, MSH6 G355S and A36V, MSH2 L719F, MEN1 G508D, BRCA1 SS955S, BRCA2 G2508S, and a GNAS inframe insertion. 26530882 2015
Entrez Id: 4436
Gene Symbol: MSH2
MSH2 		0.300 Biomarker disease GENOMICS_ENGLAND Cancer spectrum in DNA mismatch repair gene mutation carriers: results from a hospital based Lynch syndrome registry. 22714864 2012
Entrez Id: 3026
Gene Symbol: HABP2
HABP2 		0.020 GeneticVariation disease BEFREE This Journal recently published a study (Kern et al., 2017) reporting the genetic analysis of the whole HABP2 gene in 11 independent kindreds with familial non medullary thyroid cancer (FNMTC). 28779995 2018
Entrez Id: 3026
Gene Symbol: HABP2
HABP2 		0.020 GeneticVariation disease BEFREE HABP2 G534E variation in familial non-medullary thyroid cancer: an Italian series. 27873212 2017
Entrez Id: 2048
Gene Symbol: EPHB2
EPHB2 		0.010 Biomarker disease BEFREE Whole Genome Sequencing of Familial Non-Medullary Thyroid Cancer Identifies Germline Alterations in MAPK/ERK and PI3K/AKT Signaling Pathways. 31614935 2019
Entrez Id: 5594
Gene Symbol: MAPK1
MAPK1 		0.010 Biomarker disease BEFREE Whole Genome Sequencing of Familial Non-Medullary Thyroid Cancer Identifies Germline Alterations in MAPK/ERK and PI3K/AKT Signaling Pathways. 31614935 2019
Entrez Id: 5979
Gene Symbol: RET
RET 		0.010 Biomarker disease BEFREE Hereditary non-medullary thyroid cancer may occur as a minor component of familial cancer syndromes (e.g. familial adenomatous polyposis) or as a primary feature (familial non-medullary thyroid cancer [FNMTC]).Among FNMTC, PTC is the most common. 21049463 2011
Entrez Id: 2158
Gene Symbol: F9
F9 		0.010 Biomarker disease BEFREE Hereditary non-medullary thyroid cancer may occur as a minor component of familial cancer syndromes (e.g. familial adenomatous polyposis) or as a primary feature (familial non-medullary thyroid cancer [FNMTC]).Among FNMTC, PTC is the most common. 21049463 2011
Entrez Id: 100126299
Gene Symbol: VTRNA2-1
VTRNA2-1 		0.010 Biomarker disease BEFREE MiR-886-3p regulates cell proliferation and migration, and is dysregulated in familial non-medullary thyroid cancer. 21998631 2011
Entrez Id: 5727
Gene Symbol: PTCH1
PTCH1 		0.010 Biomarker disease BEFREE Hereditary non-medullary thyroid cancer may occur as a minor component of familial cancer syndromes (e.g. familial adenomatous polyposis) or as a primary feature (familial non-medullary thyroid cancer [FNMTC]).Among FNMTC, PTC is the most common. 21049463 2011
Entrez Id: 8030
Gene Symbol: CCDC6
CCDC6 		0.010 Biomarker disease BEFREE Hereditary non-medullary thyroid cancer may occur as a minor component of familial cancer syndromes (e.g. familial adenomatous polyposis) or as a primary feature (familial non-medullary thyroid cancer [FNMTC]).Among FNMTC, PTC is the most common. 21049463 2011
Entrez Id: 5726
Gene Symbol: TAS2R38
TAS2R38 		0.010 Biomarker disease BEFREE Hereditary non-medullary thyroid cancer may occur as a minor component of familial cancer syndromes (e.g. familial adenomatous polyposis) or as a primary feature (familial non-medullary thyroid cancer [FNMTC]).Among FNMTC, PTC is the most common. 21049463 2011
Entrez Id: 9049
Gene Symbol: AIP
AIP 		0.010 GeneticVariation disease BEFREE Aryl hydrocarbon receptor interacting protein mutations seem not to associate with familial non-medullary thyroid cancer. 19794292 2009
Entrez Id: 7080
Gene Symbol: NKX2-1
NKX2-1 		0.010 GeneticVariation disease BEFREE Evidence for interaction between the TCO and NMTC1 loci in familial non-medullary thyroid cancer. 15173224 2004
Entrez Id: 50975
Gene Symbol: TCO
TCO 		0.010 GeneticVariation disease BEFREE Evidence for interaction between the TCO and NMTC1 loci in familial non-medullary thyroid cancer. 15173224 2004
Entrez Id: 114568
Gene Symbol: NMTC3
NMTC3 		0.010 GeneticVariation disease BEFREE Evidence for interaction between the TCO and NMTC1 loci in familial non-medullary thyroid cancer. 15173224 2004