Source: ALL
Associated Disease N. genes N. variants N. of shared genes JI g p-value g N. of shared variants JI v p-value v
CUI: C0231687
Disease: Spastic gait
Spastic gait 		62 9 26 0.24 1 4.3E-02
CUI: C1698196
Disease: Muscle Weakness Upper Limb
Muscle Weakness Upper Limb 		29 3 18 0.21 1 5.9E-02
CUI: C0037773
Disease: Spastic Paraplegia, Hereditary
Spastic Paraplegia, Hereditary 		123 0 32 0.19 0 0
CUI: C1271100
Disease: Lower limb spasticity
Lower limb spasticity 		43 5 19 0.19 1 5.3E-02
CUI: C0037771
Disease: Paraparesis, Spastic
Paraparesis, Spastic 		75 37 24 0.19 1 2.0E-02
CUI: C1849134
Disease: Impaired vibration sensation in the lower limbs
Impaired vibration sensation in the lower limbs 		39 0 18 0.19 0 0
CUI: C0238651
Disease: Ankle clonus
Ankle clonus 		32 5 16 0.18 1 5.3E-02
CUI: C0037772
Disease: Spastic Paraplegia
Spastic Paraplegia 		144 0 32 0.17 0 0
CUI: C4024921
Disease: Lower limb amyotrophy
Lower limb amyotrophy 		19 4 13 0.16 3 0.19
CUI: C0034935
Disease: Babinski Reflex
Babinski Reflex 		218 0 39 0.15 0 0
CUI: C1843663
Disease: Urinary bladder sphincter dysfunction
Urinary bladder sphincter dysfunction 		28 0 13 0.15 0 0
CUI: C0085606
Disease: Urgency of micturition
Urgency of micturition 		40 0 14 0.14 0 0
CUI: C0039273
Disease: Talipes cavus
Talipes cavus 		213 0 35 0.14 0 0
CUI: C4553976
Disease: Urinary Urgency, CTCAE 5
Urinary Urgency, CTCAE 5 		34 0 13 0.14 0 0
CUI: C0751602
Disease: Hereditary Autosomal Dominant Spastic Paraplegia
Hereditary Autosomal Dominant Spastic Paraplegia 		27 0 12 0.13 0 0
CUI: C1836696
Disease: Lower limb hyperreflexia
Lower limb hyperreflexia 		38 0 13 0.13 0 0
CUI: C1846566
Disease: Degeneration of the lateral corticospinal tracts
Degeneration of the lateral corticospinal tracts 		21 0 11 0.13 0 0
CUI: C1866129
Disease: Abnormality of the cerebellum
Abnormality of the cerebellum 		55 11 14 0.12 1 4.0E-02
CUI: C0850703
Disease: Frequent falls
Frequent falls 		94 4 18 0.12 2 0.12
CUI: C0751603
Disease: Autosomal Recessive Hereditary Spastic Paraplegia
Autosomal Recessive Hereditary Spastic Paraplegia 		20 0 10 0.12 0 0
CUI: C1836450
Disease: Distal lower limb muscle weakness
Distal lower limb muscle weakness 		49 11 13 0.12 2 8.3E-02
CUI: C0311394
Disease: Difficulty walking
Difficulty walking 		224 30 31 0.12 5 0.12
CUI: C1263857
Disease: Peripheral axonal neuropathy
Peripheral axonal neuropathy 		94 0 17 0.11 0 0
CUI: C1848736
Disease: Distal amyotrophy
Distal amyotrophy 		106 0 18 0.11 0 0
CUI: C0042024
Disease: Urinary Incontinence
Urinary Incontinence 		151 0 22 0.11 0 0