Disease: HER2 gene amplification
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
H3P23 H3 histone pseudogene 23 0.443 0.769
PSMD9 O00233 proteasome 26S subunit, non-ATPase 9 Enzyme modulator 4.9E-06 0.435 0.846
DCTN6 O00399 dynactin subunit 6 Cellular structure 5.6E-02 0.442 0.769
ARID1A O14497 AT-rich interaction domain 1A 1.00 0.455 0.846
ZNRD2 O60232 zinc ribbon domain containing 2 1.8E-07 0.443 0.769
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885
MYC P01106 MYC proto-oncogene, bHLH transcription factor Transcription factor 1.00 0.344 0.923
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923
EGF P01133 epidermal growth factor 8.5E-17 0.357 0.923
RAF1 P04049 Raf-1 proto-oncogene, serine/threonine kinase Kinase 0.85 0.418 0.885
ERBB2 P04626 erb-b2 receptor tyrosine kinase 2 Kinase 6.0E-03 0.328 0.923
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962
TYMS P04818 thymidylate synthetase Enzyme 0.72 0.425 0.846
MMP7 P09237 matrix metallopeptidase 7 Enzyme 1.0E-09 0.446 0.885
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885
RARB P10826 retinoic acid receptor beta Nuclear receptor 1.00 0.478 0.846
TOP2A P11388 DNA topoisomerase II alpha 0.99 0.497 0.731
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923
ERBB3 P21860 erb-b2 receptor tyrosine kinase 3 Kinase 1.7E-15 0.448 0.808
CCND1 P24385 cyclin D1 Enzyme modulator 0.89 0.344 0.923
YY1 P25490 YY1 transcription factor Transcription factor 0.99 0.481 0.808
MAPK3 P27361 mitogen-activated protein kinase 3 Kinase 3.7E-02 0.379 0.885
MAPK1 P28482 mitogen-activated protein kinase 1 Kinase 1.00 0.330 0.923
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885