Disease: Hereditary Diffuse Gastric Cancer
Source: CURATED ×
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
APC P25054 APC regulator of WNT signaling pathway 1.00 0.373 0.962
ARID1A O14497 AT-rich interaction domain 1A 1.00 0.455 0.846
BIRC5 O15392 baculoviral IAP repeat containing 5 Enzyme modulator 5.6E-02 0.495 0.731
BMP2 P12643 bone morphogenetic protein 2 Signaling 0.99 0.432 0.846
CASP8 Q14790 caspase 8 Enzyme 3.7E-06 0.404 0.923
CCND1 P24385 cyclin D1 Enzyme modulator 0.89 0.344 0.923
CDH1 P12830 cadherin 1 0.15 0.401 0.808
CHEK2 O96017 checkpoint kinase 2 Kinase 1.2E-24 0.460 0.808
CXCL8 P10145 C-X-C motif chemokine ligand 8 Signaling 2.7E-04 0.310 0.962
CYP2A6 P11509 cytochrome P450 family 2 subfamily A member 6 5.4E-09 0.556 0.731
DLC1 Q96QB1 DLC1 Rho GTPase activating protein 1.00 0.529 0.731
DPAGT1 Q9H3H5 dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 Enzyme 1.1E-05 0.621 0.538
DPYD Q12882 dihydropyrimidine dehydrogenase Enzyme 3.4E-22 0.493 0.846
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885
ERCC2 P18074 ERCC excision repair 2, TFIIH core complex helicase subunit Enzyme 7.1E-20 0.420 0.846
FADS1 O60427 fatty acid desaturase 1 0.37 0.582 0.769
GLI3 P10071 GLI family zinc finger 3 1.00 0.436 0.846
GREM1 O60565 gremlin 1, DAN family BMP antagonist 0.47 0.508 0.808
IGFBP3 P17936 insulin like growth factor binding protein 3 Enzyme modulator 0.91 0.439 0.808
KMT2C Q8NEZ4 lysine methyltransferase 2C 1.00 0.558 0.692
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923
KRT20 P35900 keratin 20 9.1E-11 0.388 0.846
LRRC3B Q96PB8 leucine rich repeat containing 3B Receptor 0.44 0.695 0.308
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885
MUTYH Q9UIF7 mutY DNA glycosylase Enzyme 1.3E-18 0.521 0.769