Disease: Lower limb spasticity
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
ALDH18A1 P54886 aldehyde dehydrogenase 18 family member A1 Enzyme 8.1E-04 0.551 0.769
ALS2 Q96Q42 alsin Rho guanine nucleotide exchange factor ALS2 8.7E-12 0.647 0.423
AP5Z1 O43299 adaptor related protein complex 5 subunit zeta 1 7.3E-31 0.700 0.346
ARX Q96QS3 aristaless related homeobox 0.91 0.516 0.654
ATL1 Q8WXF7 atlastin GTPase 1 Enzyme modulator 0.98 0.593 0.654
B4GALNT1 Q00973 beta-1,4-N-acetyl-galactosaminyltransferase 1 3.9E-05 0.644 0.615
BSCL2 Q96G97 BSCL2 lipid droplet biogenesis associated, seipin 1.1E-09 0.545 0.692
CAPN1 P07384 calpain 1 Enzyme 5.9E-10 0.539 0.808
CYP7B1 O75881 cytochrome P450 family 7 subfamily B member 1 Enzyme 3.3E-06 0.563 0.692
DDHD1 Q8NEL9 DDHD domain containing 1 Enzyme 0.90 0.716 0.423
FA2H Q7L5A8 fatty acid 2-hydroxylase Enzyme 0.15 0.573 0.654
GBA2 Q9HCG7 glucosylceramidase beta 2 2.0E-20 0.636 0.654
GJC2 Q5T442 gap junction protein gamma 2 Cell-cell junction 1.0E-02 0.593 0.692
HACE1 Q8IYU2 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 Enzyme 6.1E-06 0.601 0.692
HSPD1 P10809 heat shock protein family D (Hsp60) member 1 0.99 0.432 0.808
KIF1A Q12756 kinesin family member 1A Cellular structure 1.00 0.559 0.692
KIF5A Q12840 kinesin family member 5A Cellular structure 1.00 0.593 0.731
NIPA1 Q7RTP0 NIPA magnesium transporter 1 Transporter 5.9E-03 0.682 0.462
PLP1 P60201 proteolipid protein 1 Cellular structure 0.93 0.543 0.769
SACS Q9NZJ4 sacsin molecular chaperone 1.1E-23 0.606 0.654
SLC2A1 P11166 solute carrier family 2 member 1 Transporter 0.99 0.388 0.808
SPAST Q9UBP0 spastin Cellular structure 1.00 0.579 0.577
SPG11 Q96JI7 SPG11 vesicle trafficking associated, spatacsin 1.6E-39 0.576 0.538
SPG7 Q9UQ90 SPG7 matrix AAA peptidase subunit, paraplegin Enzyme 2.0E-36 0.436 0.885
STUB1 Q9UNE7 STIP1 homology and U-box containing protein 1 1.9E-02 0.544 0.692