Disease: Spastic Paraplegia
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
SPG11 Q96JI7 SPG11 vesicle trafficking associated, spatacsin 1.6E-39 0.576 0.538
C19orf12 Q9NSK7 chromosome 19 open reading frame 12 0.34 0.641 0.615
CYP2U1 Q7Z449 cytochrome P450 family 2 subfamily U member 1 1.4E-03 0.722 0.462
ZFYVE27 Q5T4F4 zinc finger FYVE-type containing 27 1.1E-09 0.805 0.308
IBA57 Q5T440 iron-sulfur cluster assembly factor IBA57 8.4E-03 0.666 0.423
C9orf72 Q96LT7 C9orf72-SMCR8 complex subunit 1.1E-06 0.496 0.769
KY Q8NBH2 kyphoscoliosis peptidase 1.5E-10 0.736 0.231
GJC2 Q5T442 gap junction protein gamma 2 Cell-cell junction 1.0E-02 0.593 0.692
KIF1A Q12756 kinesin family member 1A Cellular structure 1.00 0.559 0.692
KIF5A Q12840 kinesin family member 5A Cellular structure 1.00 0.593 0.731
PLP1 P60201 proteolipid protein 1 Cellular structure 0.93 0.543 0.769
SPAST Q9UBP0 spastin Cellular structure 1.00 0.579 0.577
KIF1C O43896 kinesin family member 1C Cellular structure 0.72 0.700 0.500
KIF1B O60333 kinesin family member 1B Cellular structure 1.00 0.516 0.808
CAPN1 P07384 calpain 1 Enzyme 5.9E-10 0.539 0.808
DYNC1H1 Q14204 dynein cytoplasmic 1 heavy chain 1 Enzyme 1.00 0.547 0.769
ALDH18A1 P54886 aldehyde dehydrogenase 18 family member A1 Enzyme 8.1E-04 0.551 0.769
SPG7 Q9UQ90 SPG7 matrix AAA peptidase subunit, paraplegin Enzyme 2.0E-36 0.436 0.885
UCHL1 P09936 ubiquitin C-terminal hydrolase L1 Enzyme 0.99 0.482 0.885
CYP7B1 O75881 cytochrome P450 family 7 subfamily B member 1 Enzyme 3.3E-06 0.563 0.692
PNPLA6 Q8IY17 patatin like phospholipase domain containing 6 Enzyme 1.9E-13 0.533 0.769
NT5C2 P49902 5'-nucleotidase, cytosolic II Enzyme 2.1E-06 0.537 0.846
DDHD2 O94830 DDHD domain containing 2 Enzyme 1.4E-10 0.695 0.577
PDXP Q96GD0 pyridoxal phosphatase Enzyme 0.26 0.533 0.731
FA2H Q7L5A8 fatty acid 2-hydroxylase Enzyme 0.15 0.573 0.654