Disease: Alzheimer disease, familial, type 3
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
PICALM Q13492 phosphatidylinositol binding clathrin assembly protein Transporter 1.00 0.592 0.538
APOD P05090 apolipoprotein D 5.4E-04 0.584 0.577
NRGN Q92686 neurogranin 0.48 0.608 0.615
SORT1 Q99523 sortilin 1 Transporter 1.00 0.573 0.615
CFDP1 Q9UEE9 craniofacial development protein 1 3.7E-03 0.619 0.615
PSEN2 P49810 presenilin 2 Enzyme 5.4E-04 0.550 0.654
SUCLA2 Q9P2R7 succinate-CoA ligase ADP-forming subunit beta Enzyme 2.3E-03 0.566 0.654
EIF4G2 P78344 eukaryotic translation initiation factor 4 gamma 2 Nucleic acid binding 1.00 0.593 0.692
PSMD2 Q13200 proteasome 26S subunit, non-ATPase 2 Enzyme modulator 1.00 0.612 0.692
NEFL P07196 neurofilament light 0.488 0.769
POLD1 P28340 DNA polymerase delta 1, catalytic subunit 2.4E-06 0.507 0.769
TFPI2 P48307 tissue factor pathway inhibitor 2 Enzyme modulator 8.4E-04 0.521 0.769
TREM2 Q9NZC2 triggering receptor expressed on myeloid cells 2 3.3E-09 0.519 0.769
MCIDAS D6RGH6 multiciliate differentiation and DNA synthesis associated cell cycle protein 1.3E-02 0.566 0.769
MIR181C microRNA 181c 0.555 0.769
HCRT O43612 hypocretin neuropeptide precursor 2.9E-02 0.500 0.808
GEMIN4 P57678 gem nuclear organelle associated protein 4 5.9E-13 0.565 0.808
LRRK2 Q5S007 leucine rich repeat kinase 2 Kinase 2.6E-30 0.510 0.808
APEX1 P27695 apurinic/apyrimidinic endodeoxyribonuclease 1 1.9E-07 0.458 0.846
APP P05067 amyloid beta precursor protein Enzyme modulator 4.7E-02 0.422 0.846
GRN P28799 granulin precursor 7.0E-02 0.435 0.846
PSEN1 P49768 presenilin 1 Enzyme 0.97 0.469 0.846
ACHE P22303 acetylcholinesterase (Cartwright blood group) Enzyme 1.00 0.445 0.885
CHI3L1 P36222 chitinase 3 like 1 1.1E-05 0.419 0.885
CLU P10909 clusterin 7.8E-05 0.426 0.885