Disease: Developmental regression
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
IL10 P22301 interleukin 10 5.9E-03 0.281 0.923
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923
TLR4 O00206 toll like receptor 4 4.6E-09 0.321 0.962
FAS P25445 Fas cell surface death receptor 0.81 0.372 0.923
HLA-B P01889 major histocompatibility complex, class I, B 3.9E-05 0.379 0.885
MLH1 P40692 mutL homolog 1 Nucleic acid binding 3.4E-05 0.399 0.808
MSH2 P43246 mutS homolog 2 Nucleic acid binding 0.90 0.406 0.808
TGFBR2 P37173 transforming growth factor beta receptor 2 Kinase 0.13 0.413 0.846
MECP2 P51608 methyl-CpG binding protein 2 Epigenetic regulator 0.89 0.414 0.846
NOTCH3 Q9UM47 notch receptor 3 0.41 0.435 0.808
MEFV O15553 MEFV innate immuity regulator, pyrin 1.0E-14 0.440 0.885
ARSA P15289 arylsulfatase A Enzyme 1.1E-11 0.448 0.923
EPCAM P16422 epithelial cell adhesion molecule 1.3E-07 0.451 0.885
POLG P54098 DNA polymerase gamma, catalytic subunit Enzyme 2.1E-09 0.457 0.846
MSH6 P52701 mutS homolog 6 Nucleic acid binding 3.7E-05 0.462 0.731
IL23R Q5VWK5 interleukin 23 receptor Signaling 5.6E-04 0.466 0.769
STAT4 Q14765 signal transducer and activator of transcription 4 Nucleic acid binding 0.77 0.471 0.769
PMS2 P54278 PMS1 homolog 2, mismatch repair system component Nucleic acid binding 4.5E-27 0.484 0.808
IL12A P29459 interleukin 12A 4.7E-02 0.491 0.808
GBA P04062 glucosylceramidase beta 1.4E-06 0.500 0.808
ARX Q96QS3 aristaless related homeobox 0.91 0.516 0.654
TREM2 Q9NZC2 triggering receptor expressed on myeloid cells 2 3.3E-09 0.519 0.769
BMPR1A P36894 bone morphogenetic protein receptor type 1A Kinase 0.90 0.522 0.731