Disease: Keratoderma, Palmoplantar
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962
ALOX12B O75342 arachidonate 12-lipoxygenase, 12R type Enzyme 7.6E-04 0.603 0.577
ALOXE3 Q9BYJ1 arachidonate lipoxygenase 3 Enzyme 5.1E-20 0.644 0.538
ABCA12 Q86UK0 ATP binding cassette subfamily A member 12 Transporter 2.9E-15 0.610 0.654
ATP2A2 P16615 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 Transporter 1.00 0.529 0.808
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846
CARD14 Q9BXL6 caspase recruitment domain family member 14 1.2E-19 0.546 0.846
CTSC P53634 cathepsin C Enzyme 1.1E-07 0.541 0.731
CD28 P10747 CD28 molecule 0.36 0.436 0.885
CTLA4 P16410 cytotoxic T-lymphocyte associated protein 4 0.94 0.369 0.923
DSG1 Q02413 desmoglein 1 Cell adhesion 0.93 0.606 0.538
DSP P15924 desmoplakin Cellular structure 1.00 0.514 0.808
ENPP1 P22413 ectonucleotide pyrophosphatase/phosphodiesterase 1 Enzyme 5.0E-08 0.498 0.808
EVPL Q92817 envoplakin Cellular structure 5.7E-25 0.599 0.423
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885
GABPA Q06546 GA binding protein transcription factor subunit alpha Transcription factor 1.00 0.379 0.885
GJA1 P17302 gap junction protein alpha 1 Cell-cell junction 0.16 0.393 0.885
GJB2 P29033 gap junction protein beta 2 Cell-cell junction 6.6E-16 0.441 0.846
GJB3 O75712 gap junction protein beta 3 Cell-cell junction 2.2E-03 0.621 0.462
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962
KLKB1 P03952 kallikrein B1 Enzyme 6.3E-13 0.604 0.692
KEAP1 Q14145 kelch like ECH associated protein 1 3.9E-04 0.475 0.808
KRT1 P04264 keratin 1 0.74 0.575 0.654
KRT10 P13645 keratin 10 2.5E-03 0.579 0.692
KRT14 P02533 keratin 14 2.0E-04 0.530 0.731