Disease: Malignant transformation
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923
ACTB P60709 actin beta Cellular structure 0.99 0.325 0.923
APOE P02649 apolipoprotein E 1.9E-03 0.338 0.962
NLRP3 Q96P20 NLR family pyrin domain containing 3 8.1E-04 0.361 0.962
MDM2 Q00987 MDM2 proto-oncogene Nucleic acid binding 1.00 0.362 0.846
KIT P10721 KIT proto-oncogene, receptor tyrosine kinase Kinase 0.98 0.366 0.808
HMGB1 P09429 high mobility group box 1 Nucleic acid binding 0.82 0.368 0.923
NOTCH1 P46531 notch receptor 1 1.00 0.369 0.885
JAK2 O60674 Janus kinase 2 Kinase 0.65 0.385 0.885
STAT1 P42224 signal transducer and activator of transcription 1 Nucleic acid binding 1.00 0.399 0.885
ESR2 Q92731 estrogen receptor 2 Nuclear receptor 4.5E-08 0.400 0.923
RUNX1 Q01196 RUNX family transcription factor 1 Transcription factor 0.65 0.425 0.808
MCL1 Q07820 MCL1 apoptosis regulator, BCL2 family member Signaling 0.96 0.430 0.808
FOXO1 Q12778 forkhead box O1 1.00 0.433 0.846
FOXM1 Q08050 forkhead box M1 7.4E-04 0.441 0.769
F2R P25116 coagulation factor II thrombin receptor G-protein coupled receptor 8.5E-03 0.444 0.846
ERG P11308 ETS transcription factor ERG Transcription factor 0.96 0.453 0.808
SLC12A9 Q9BXP2 solute carrier family 12 member 9 Transporter 1.2E-15 0.454 0.769
FOXP1 Q9H334 forkhead box P1 1.00 0.460 0.808
MBD2 Q9UBB5 methyl-CpG binding domain protein 2 Epigenetic regulator 0.35 0.466 0.846
GTF2H1 P32780 general transcription factor IIH subunit 1 Transcription factor 0.99 0.469 0.846
SMAD7 O15105 SMAD family member 7 Transcription factor 0.55 0.470 0.769
CDK6 Q00534 cyclin dependent kinase 6 Kinase 0.98 0.471 0.731