Disease: Ichthyosis, X-Linked
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
MLRL Myeloid leukemia-related gene (myeloid tumor suppressor) 0.564 0.769
PIK3CD O00329 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Kinase 1.00 0.319 0.885
TIMM8A O60220 translocase of inner mitochondrial membrane 8A 0.65 0.510 0.846
CHEK2 O96017 checkpoint kinase 2 Kinase 1.2E-24 0.460 0.808
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885
TIMP1 P01033 TIMP metallopeptidase inhibitor 1 Enzyme modulator 0.50 0.380 0.885
MYC P01106 MYC proto-oncogene, bHLH transcription factor Transcription factor 1.00 0.344 0.923
NRAS P01111 NRAS proto-oncogene, GTPase Enzyme modulator 0.49 0.390 0.808
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885
EGF P01133 epidermal growth factor 8.5E-17 0.357 0.923
ERBB2 P04626 erb-b2 receptor tyrosine kinase 2 Kinase 6.0E-03 0.328 0.923
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962
TYMS P04818 thymidylate synthetase Enzyme 0.72 0.425 0.846
CDK1 P06493 cyclin dependent kinase 1 Kinase 0.99 0.482 0.808
RARA P10276 retinoic acid receptor alpha Nuclear receptor 0.96 0.470 0.846
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885
KIT P10721 KIT proto-oncogene, receptor tyrosine kinase Kinase 0.98 0.366 0.808
FGFR1 P11362 fibroblast growth factor receptor 1 Kinase 1.00 0.362 0.885
TOP2A P11388 DNA topoisomerase II alpha 0.99 0.497 0.731
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846
EZR P15311 ezrin Cellular structure 0.18 0.476 0.808
NME1 P15531 NME/NM23 nucleoside diphosphate kinase 1 Kinase 3.2E-03 0.443 0.808
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923
CD44 P16070 CD44 molecule (Indian blood group) 2.4E-07 0.363 0.962
PDGFRA P16234 platelet derived growth factor receptor alpha Kinase 1.00 0.415 0.808