Disease: Amyotrophic Lateral Sclerosis, Sporadic
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
HNRNPA3 P51991 heterogeneous nuclear ribonucleoprotein A3 1.00 0.751 0.308
UBQLN2 Q9UHD9 ubiquilin 2 0.85 0.656 0.462
TMEM106B Q9NUM4 transmembrane protein 106B 0.33 0.590 0.462
INA Q16352 internexin neuronal intermediate filament protein alpha 1.5E-08 0.633 0.500
MATR3 P43243 matrin 3 1.00 0.631 0.538
SNCG O76070 synuclein gamma Transporter 8.5E-04 0.550 0.615
PNO1 Q9NRX1 partner of NOB1 homolog 0.23 0.564 0.615
MAK16 Q9BXY0 MAK16 homolog 0.96 0.566 0.615
SRRM2 Q9UQ35 serine/arginine repetitive matrix 2 1.00 0.564 0.692
RBMS3 Q6XE24 RNA binding motif single stranded interacting protein 3 0.21 0.553 0.692
PFN1 P07737 profilin 1 0.73 0.565 0.769
PTBP1 P26599 polypyrimidine tract binding protein 1 1.00 0.517 0.769
DISC1 Q9NRI5 DISC1 scaffold protein 1.7E-06 0.548 0.769
TREM2 Q9NZC2 triggering receptor expressed on myeloid cells 2 3.3E-09 0.519 0.769
C9orf72 Q96LT7 C9orf72-SMCR8 complex subunit 1.1E-06 0.496 0.769
CST3 P01034 cystatin C 3.9E-03 0.436 0.808
ATXN2 Q99700 ataxin 2 Nucleic acid binding 0.85 0.482 0.808
OPTN Q96CV9 optineurin 5.9E-18 0.548 0.808
TARDBP Q13148 TAR DNA binding protein 0.99 0.493 0.808
FUS P35637 FUS RNA binding protein Nucleic acid binding 1.00 0.470 0.846
GRN P28799 granulin precursor 7.0E-02 0.435 0.846
IGFALS P35858 insulin like growth factor binding protein acid labile subunit Receptor 5.4E-11 0.511 0.846
TBK1 Q9UHD2 TANK binding kinase 1 Kinase 7.5E-02 0.513 0.846
SQSTM1 Q13501 sequestosome 1 8.6E-04 0.428 0.885
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923