Disease: Amyotrophic Lateral Sclerosis, Sporadic
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
SNCG O76070 synuclein gamma Transporter 8.5E-04 0.550 0.615
SOD1 P00441 superoxide dismutase 1 Enzyme 0.18 0.379 0.962
CST3 P01034 cystatin C 3.9E-03 0.436 0.808
APOE P02649 apolipoprotein E 1.9E-03 0.338 0.962
PFN1 P07737 profilin 1 0.73 0.565 0.769
MAPT P10636 microtubule associated protein tau 6.0E-03 0.446 0.923
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923
PTBP1 P26599 polypyrimidine tract binding protein 1 1.00 0.517 0.769
GRN P28799 granulin precursor 7.0E-02 0.435 0.846
FUS P35637 FUS RNA binding protein Nucleic acid binding 1.00 0.470 0.846
IGFALS P35858 insulin like growth factor binding protein acid labile subunit Receptor 5.4E-11 0.511 0.846
MATR3 P43243 matrin 3 1.00 0.631 0.538
HNRNPA3 P51991 heterogeneous nuclear ribonucleoprotein A3 1.00 0.751 0.308
VCP P55072 valosin containing protein 1.00 0.469 0.923
TARDBP Q13148 TAR DNA binding protein 0.99 0.493 0.808
SQSTM1 Q13501 sequestosome 1 8.6E-04 0.428 0.885
INA Q16352 internexin neuronal intermediate filament protein alpha 1.5E-08 0.633 0.500
RBMS3 Q6XE24 RNA binding motif single stranded interacting protein 3 0.21 0.553 0.692
OPTN Q96CV9 optineurin 5.9E-18 0.548 0.808
C9orf72 Q96LT7 C9orf72-SMCR8 complex subunit 1.1E-06 0.496 0.769
ATXN2 Q99700 ataxin 2 Nucleic acid binding 0.85 0.482 0.808
MAK16 Q9BXY0 MAK16 homolog 0.96 0.566 0.615
DISC1 Q9NRI5 DISC1 scaffold protein 1.7E-06 0.548 0.769
PNO1 Q9NRX1 partner of NOB1 homolog 0.23 0.564 0.615