|
rs17107315
|
|
|
0.080 |
GeneticVariation |
BEFREE |
SPINK1 N34S mutation enhances the susceptibility of AP.
|
15782101 |
2005 |
|
rs777418530
|
|
|
0.020 |
GeneticVariation |
BEFREE |
SPINK1 N34S mutation enhances the susceptibility of AP.
|
15782101 |
2005 |
|
rs111033565
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The cationic trypsinogen (PRSS1) R122H mutation causes autosomal dominant hereditary pancreatitis (HP) with multiple attacks of acute pancreatitis, but the penetrance, frequency, and severity of attacks are highly variable.
|
16354799 |
2006 |
|
rs267606982
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The cationic trypsinogen (PRSS1) R122H mutation causes autosomal dominant hereditary pancreatitis (HP) with multiple attacks of acute pancreatitis, but the penetrance, frequency, and severity of attacks are highly variable.
|
16354799 |
2006 |
|
rs4986790
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Toll-like receptor 4 Asp299Gly polymorphism is associated with the infection of pancreatic necrosis in AP.
|
17414051 |
2007 |
|
rs4986790
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In view of the inflammatory nature of acute pancreatitis, we aimed to determine the predictive value of two point mutations in the promoter region at position -550 (H/L variants) and -221 (X/Y variants) of the MBL2 gene, and the Asp299Gly and 119C>A polymorphisms of the TLR4 gene on the occurrence of severe acute pancreatitis (SAP).
|
18288881 |
2008 |
|
rs17107315
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The SPINK1 N34S variant is associated with acute pancreatitis.
|
18617776 |
2008 |
|
rs777418530
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The SPINK1 N34S variant is associated with acute pancreatitis.
|
18617776 |
2008 |
|
rs61734659
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The p.G191R variant protected against alcoholic and idiopathic chronic pancreatitis as well as alcoholic acute pancreatitis in Japan.
|
19052022 |
2009 |
|
rs748405415
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The p.G191R variant protected against alcoholic and idiopathic chronic pancreatitis as well as alcoholic acute pancreatitis in Japan.
|
19052022 |
2009 |
|
rs5275
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These findings suggest that the rs5275 polymorphism in the 3'-untranslated region of the COX-2 gene may be used as 1 marker for defining the risk of AP.
|
19820421 |
2010 |
|
rs17107315
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The SPINK1 N34S polymorphism was not associated with the sentinel AP attack, but it substantially increases the risk of recurrent attacks.
|
19888199 |
2010 |
|
rs111033565
|
|
|
0.030 |
GeneticVariation |
BEFREE |
A total of 261 patients with AP (174 with a sentinel attack, and 87 with recurrent attacks) and healthy controls were genotyped for the p.R122H mutation in the PRSS1 gene, p.N34S and IVS3 + 2T > C variants in the SPINK1 gene, the p.G191R variant in the anionic trypsinogen gene, the p.E32del variant in the mesotrypsinogen (PRSS3) gene, and the -2518G > A variant in the monocyte chemoattractant protein-1 gene by polymerase chain reaction-restriction enzyme digestion and direct sequencing.
|
21303407 |
2011 |
|
rs267606982
|
|
|
0.030 |
GeneticVariation |
BEFREE |
A total of 261 patients with AP (174 with a sentinel attack, and 87 with recurrent attacks) and healthy controls were genotyped for the p.R122H mutation in the PRSS1 gene, p.N34S and IVS3 + 2T > C variants in the SPINK1 gene, the p.G191R variant in the anionic trypsinogen gene, the p.E32del variant in the mesotrypsinogen (PRSS3) gene, and the -2518G > A variant in the monocyte chemoattractant protein-1 gene by polymerase chain reaction-restriction enzyme digestion and direct sequencing.
|
21303407 |
2011 |
|
rs61734659
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A total of 261 patients with AP (174 with a sentinel attack, and 87 with recurrent attacks) and healthy controls were genotyped for the p.R122H mutation in the PRSS1 gene, p.N34S and IVS3 + 2T > C variants in the SPINK1 gene, the p.G191R variant in the anionic trypsinogen gene, the p.E32del variant in the mesotrypsinogen (PRSS3) gene, and the -2518G > A variant in the monocyte chemoattractant protein-1 gene by polymerase chain reaction-restriction enzyme digestion and direct sequencing.
|
21303407 |
2011 |
|
rs748405415
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A total of 261 patients with AP (174 with a sentinel attack, and 87 with recurrent attacks) and healthy controls were genotyped for the p.R122H mutation in the PRSS1 gene, p.N34S and IVS3 + 2T > C variants in the SPINK1 gene, the p.G191R variant in the anionic trypsinogen gene, the p.E32del variant in the mesotrypsinogen (PRSS3) gene, and the -2518G > A variant in the monocyte chemoattractant protein-1 gene by polymerase chain reaction-restriction enzyme digestion and direct sequencing.
|
21303407 |
2011 |
|
rs139635080
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A total of 261 patients with AP (174 with a sentinel attack, and 87 with recurrent attacks) and healthy controls were genotyped for the p.R122H mutation in the PRSS1 gene, p.N34S and IVS3 + 2T > C variants in the SPINK1 gene, the p.G191R variant in the anionic trypsinogen gene, the p.E32del variant in the mesotrypsinogen (PRSS3) gene, and the -2518G > A variant in the monocyte chemoattractant protein-1 gene by polymerase chain reaction-restriction enzyme digestion and direct sequencing.
|
21303407 |
2011 |
|
rs146966861
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A total of 261 patients with AP (174 with a sentinel attack, and 87 with recurrent attacks) and healthy controls were genotyped for the p.R122H mutation in the PRSS1 gene, p.N34S and IVS3 + 2T > C variants in the SPINK1 gene, the p.G191R variant in the anionic trypsinogen gene, the p.E32del variant in the mesotrypsinogen (PRSS3) gene, and the -2518G > A variant in the monocyte chemoattractant protein-1 gene by polymerase chain reaction-restriction enzyme digestion and direct sequencing.
|
21303407 |
2011 |
|
rs752688735
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A total of 261 patients with AP (174 with a sentinel attack, and 87 with recurrent attacks) and healthy controls were genotyped for the p.R122H mutation in the PRSS1 gene, p.N34S and IVS3 + 2T > C variants in the SPINK1 gene, the p.G191R variant in the anionic trypsinogen gene, the p.E32del variant in the mesotrypsinogen (PRSS3) gene, and the -2518G > A variant in the monocyte chemoattractant protein-1 gene by polymerase chain reaction-restriction enzyme digestion and direct sequencing.
|
21303407 |
2011 |
|
rs756271986
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A total of 261 patients with AP (174 with a sentinel attack, and 87 with recurrent attacks) and healthy controls were genotyped for the p.R122H mutation in the PRSS1 gene, p.N34S and IVS3 + 2T > C variants in the SPINK1 gene, the p.G191R variant in the anionic trypsinogen gene, the p.E32del variant in the mesotrypsinogen (PRSS3) gene, and the -2518G > A variant in the monocyte chemoattractant protein-1 gene by polymerase chain reaction-restriction enzyme digestion and direct sequencing.
|
21303407 |
2011 |
|
rs764176833
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A total of 261 patients with AP (174 with a sentinel attack, and 87 with recurrent attacks) and healthy controls were genotyped for the p.R122H mutation in the PRSS1 gene, p.N34S and IVS3 + 2T > C variants in the SPINK1 gene, the p.G191R variant in the anionic trypsinogen gene, the p.E32del variant in the mesotrypsinogen (PRSS3) gene, and the -2518G > A variant in the monocyte chemoattractant protein-1 gene by polymerase chain reaction-restriction enzyme digestion and direct sequencing.
|
21303407 |
2011 |
|
rs17107315
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The SPINK1 variant p.N34S is overrepresented in patients with acute pancreatitis, but more studies distinguishing between first-time and recurrent acute pancreatitis have to be done to determine whether this is only true for patients with recurrent acute pancreatitis.
|
22228370 |
2012 |
|
rs2071746
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The GT-repeat and SNP rs2071746 were investigated with fluorescence labelled primers and by melting curve analysis in 285 patients with acute pancreatitis, 208 patients with alcoholic CP, 207 patients with idiopathic/hereditary CP, 147 patients with alcoholic liver cirrhosis, and in 289 controls, respectively.
|
22666428 |
2012 |
|
rs17107315
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Patients bearing the N34S G allele exhibited a 10-fold increased risk of developing AP compared with controls, suggesting that the SPINK1 N34S mutation represents an etiologic risk factor for AP in our Mexican pediatric patients.
|
22699143 |
2012 |
|
rs111033565
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The study's objective was to assess the association between the PRSS1 R122H and N29I and the SPINK1 N34S mutations and acute pancreatitis (AP) and recurrent pancreatitis in Mexican pediatric patients.
|
22699143 |
2012 |