Gene: ADH4 ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs5860563
rs5860563
ADH4 ; LOC100507053
0.700 GeneticVariation GWASCAT Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations. 30940813

2019
dbSNP: rs17028615
rs17028615
ADH4 ; LOC100507053
A 0.700 GeneticVariation GWASCAT Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci. 24166409

2014
dbSNP: rs1042364
rs1042364
ADH4 ; LOC100507053
0.020 GeneticVariation BEFREE The interactions of religious involvement with ADH1B-rs2066702, ADH1C-rs698, and ADH4-rs1042364 were significantly associated with maximum drinks and alcohol dependence symptoms. 27172571

2016
dbSNP: rs1042364
rs1042364
ADH4 ; LOC100507053
0.020 GeneticVariation BEFREE Both variants--rs1800759 and rs10</span>42364--and the A-A and C-G haplotypes were significantly related to AD across samples. 20626721

2011
dbSNP: rs1800759
rs1800759
ADH4 ; LOC100507053
0.020 GeneticVariation BEFREE Both variants--rs18</span>00759 and rs1042364--and the A-A and C-G haplotypes were significantly related to AD across samples. 20626721

2011
dbSNP: rs3762894
rs3762894
ADH4 ; LOC100507053
0.020 GeneticVariation BEFREE The ADH4 SNP rs3762894 was associated with AD in Plains Indians. 21083667

2011
dbSNP: rs3762894
rs3762894
ADH4 ; LOC100507053
0.020 GeneticVariation BEFREE No evidence for association with the alcohol dependence diagnosis was observed, but an SNP in exon 9 of ADH1B (rs2066702; ADH1B*3) and an SNP at the 5' end of ADH4 (rs3762894) showed significant evidence of association with the presence of withdrawal symptoms (p = 0.0018 and 0.0012, respectively). 21635275

2011
dbSNP: rs1800759
rs1800759
ADH4 ; LOC100507053
0.020 GeneticVariation BEFREE Among all markers, SNP2 (rs1042363) at exon 9 or SNP6 (rs1800759) at the promoter showed the greatest degree of HWD, among patients with either alcohol dependence or drug dependence. 16237392

2006
dbSNP: rs10009145
rs10009145
ADH4 ; LOC100507053
0.010 GeneticVariation BEFREE Haplotype ATAAAT, which contained the minor allele of rs10009145 and the major allele of rs7689753, increased the risk of alcohol dependence, whereas haplotype GGGGAT, bearing the major allele of rs10009145 and the minor allele of rs7689753, protected against it. 22044940

2012
dbSNP: rs7689753
rs7689753
ADH4 ; LOC100507053
0.010 GeneticVariation BEFREE Haplotype ATAAAT, which contained the minor allele of rs10009145 and the major allele of rs7689753, increased the risk of alcohol dependence, whereas haplotype GGGGAT, bearing the major allele of rs10009145 and the minor allele of rs7689753, protected against it. 22044940

2012
dbSNP: rs1126671
rs1126671
ADH4 ; LOC100507053
0.010 GeneticVariation BEFREE Logistic regression analysis showed that: (i) the genotypes of SNP2 (rs1042363) were significantly associated with alcohol dependence and drug dependence (mainly cocaine dependence), and the genotypes of SNP3 (rs1126671) were also significantly associated with alcohol dependence and (ii) one seven-variant haplotype and one diplotype were significantly associated with alcohol dependence and other seven-variant diplotypes were significantly associated with drug dependence (including cocaine and opioid dependence). 16220108

2005