|
rs157581
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We analyzed rs-fMRI characteristics of TOMM40 rs157581-G carriers of AD for the first time, which suggest that TOMM40 rs157581-G plays a harmful role in AD patients.
|
31568198 |
2019 |
|
rs10524523
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To interrogate a poly-T variant (rs10524523, '523) in <i>TOMM40</i>, a gene adjacent to the <i>APOE</i> gene on chromosome 19, in older persons with <i>APOE</i> ε3/3 homozygosity for association with cognitive decline, the clinical hallmark of Alzheimer disease (AD).
|
28108637 |
2017 |
|
rs10524523
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Family history (FH) of Alzheimer's disease (AD) affects mitochondrial function and may modulate effects of translocase of the outer mitochondrial membrane 40 kDa (TOMM40) rs10524523 ('523) poly-T length on memory decline.
|
28549947 |
2017 |
|
rs10524523
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The apolipoprotein E (<i>APOE</i>) genotype and a polymorphism (rs10524523) in the translocase of outer mitochondrial membrane 40 (<i>TOMM40</i>) gene have been associated with the age of onset of AD.
|
29124110 |
2017 |
|
rs10524523
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Thirty-two presenilin 1 (PSEN1) mutation carriers with AD, 27 presenilin 2 (PSEN2) mutation carriers with AD, 59 participants with late-onset AD (LOAD), and 168 autopsied subjects from a community-based cohort were genotyped for TOMM40 intron 6 poly-T (rs10524523) length using short tandem repeat assays.
|
23183136 |
2013 |
|
rs10524523
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A number of recent studies have not replicated the association of the translocase of the outer mitochondrial membrane pore subunit (TOMM40) rs10524523 polymorphism, which is in linkage disequilibrium with apolipoprotein E (APOE), with age of onset of Alzheimer's disease (AD).
|
23333464 |
2013 |
|
rs10524523
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Because of the similarities between Alzheimer's disease and sporadic inclusion body myositis (s-IBM), and the importance of amyloid-β and mitochondrial changes in s-IBM, we investigated whether variation in poly-T repeat lengths in rs10524523 also influence susceptibility and age at onset in a cohort of 90 Caucasian s-IBM patients (55 males; age 69.1 ± 9.6).
|
24103330 |
2013 |
|
rs10524523
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The APOE ε and TOMM40 rs10524523 ('523') variable length poly-T repeat gene loci have been significantly and independently associated with Alzheimer's disease (AD) related phenotypes such as age of clinical onset.
|
24260406 |
2013 |
|
rs10524523
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Role of TOMM40 rs10524523 polymorphism in onset of alzheimer's disease caused by the PSEN1 M146L mutation.
|
23792692 |
2013 |
|
rs10524523
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We previously discovered that a polymorphic, deoxythymidine-homopolymer (poly-T, rs10524523) in intron 6 of the TOMM40 gene is associated with age-of-onset of Alzheimer's disease and with cognitive performance in elderly.
|
22359560 |
2012 |
|
rs10524523
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To evaluate the association of risk and age at onset (AAO) of Alzheimer disease (AD) with single-nucleotide polymorphisms (SNPs) in the chromosome 19 region including apolipoprotein E (APOE) and a repeat-length polymorphism in TOMM40 (poly-T, rs10524523).
|
22869155 |
2012 |
|
rs1160984
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.
|
30617256 |
2019 |
|
rs141864196
|
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.
|
30617256 |
2019 |
|
rs142412517
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.
|
30617256 |
2019 |
|
rs561654715
|
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.
|
30617256 |
2019 |
|
rs71352238
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide analysis of genetic predisposition to Alzheimer's disease and related sex disparities.
|
30636644 |
2019 |
|
rs76692773
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.
|
30617256 |
2019 |
|
rs77301115
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Shared genetic architecture between metabolic traits and Alzheimer's disease: a large-scale genome-wide cross-trait analysis.
|
30805717 |
2019 |
|
rs11668327
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
GWAS on family history of Alzheimer's disease.
|
29777097 |
2018 |
|
rs117310449
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
GWAS on family history of Alzheimer's disease.
|
29777097 |
2018 |
|
rs141864196
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
GWAS on family history of Alzheimer's disease.
|
29777097 |
2018 |
|
rs35568738
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
GWAS on family history of Alzheimer's disease.
|
29777097 |
2018 |
|
rs61679753
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
GWAS on family history of Alzheimer's disease.
|
29777097 |
2018 |
|
rs394819
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
F-box/LRR-repeat protein 7 is genetically associated with Alzheimer's disease.
|
26339675 |
2015 |
|
rs11556505
|
|
|
0.700 |
GeneticVariation |
GWASDB |
ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology.
|
24770881 |
2014 |