Gene: TOMM40 ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs10119
rs10119
TOMM40
0.700 GeneticVariation GWASDB Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. 21460841

2011
dbSNP: rs10119
rs10119
TOMM40
0.700 GeneticVariation GWASDB Genome-wide association study of Alzheimer's disease. 22832961

2012
dbSNP: rs10119
rs10119
TOMM40
0.700 GeneticVariation GWASDB Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. 19734903

2009
dbSNP: rs1038025
rs1038025
TOMM40
T 0.700 GeneticVariation GWASDB SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians. 23565137

2013
dbSNP: rs1038026
rs1038026
TOMM40
A 0.700 GeneticVariation GWASDB SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians. 23565137

2013
dbSNP: rs10524523
rs10524523
TOMM40
0.100 GeneticVariation BEFREE We previously discovered that a polymorphic, deoxythymidine-homopolymer (poly-T, rs10524523) in intron 6 of the TOMM40 gene is associated with age-of-onset of Alzheimer's disease and with cognitive performance in elderly. 22359560

2012
dbSNP: rs10524523
rs10524523
TOMM40
0.100 GeneticVariation BEFREE Thirty-two presenilin 1 (PSEN1) mutation carriers with AD, 27 presenilin 2 (PSEN2) mutation carriers with AD, 59 participants with late-onset AD (LOAD), and 168 autopsied subjects from a community-based cohort were genotyped for TOMM40 intron 6 poly-T (rs10524523) length using short tandem repeat assays. 23183136

2013
dbSNP: rs10524523
rs10524523
TOMM40
0.100 GeneticVariation BEFREE A number of recent studies have not replicated the association of the translocase of the outer mitochondrial membrane pore subunit (TOMM40) rs10524523 polymorphism, which is in linkage disequilibrium with apolipoprotein E (APOE), with age of onset of Alzheimer's disease (AD). 23333464

2013
dbSNP: rs10524523
rs10524523
TOMM40
0.100 GeneticVariation BEFREE To interrogate a poly-T variant (rs10524523, '523) in <i>TOMM40</i>, a gene adjacent to the <i>APOE</i> gene on chromosome 19, in older persons with <i>APOE</i> ε3/3 homozygosity for association with cognitive decline, the clinical hallmark of Alzheimer disease (AD). 28108637

2017
dbSNP: rs10524523
rs10524523
TOMM40
0.100 GeneticVariation BEFREE Because of the similarities between Alzheimer's disease and sporadic inclusion body myositis (s-IBM), and the importance of amyloid-β and mitochondrial changes in s-IBM, we investigated whether variation in poly-T repeat lengths in rs10524523 also influence susceptibility and age at onset in a cohort of 90 Caucasian s-IBM patients (55 males; age 69.1 ± 9.6). 24103330

2013
dbSNP: rs10524523
rs10524523
TOMM40
0.100 GeneticVariation BEFREE The APOE ε and TOMM40 rs10524523 ('523') variable length poly-T repeat gene loci have been significantly and independently associated with Alzheimer's disease (AD) related phenotypes such as age of clinical onset. 24260406

2013
dbSNP: rs10524523
rs10524523
TOMM40
0.100 GeneticVariation BEFREE To evaluate the association of risk and age at onset (AAO) of Alzheimer disease (AD) with single-nucleotide polymorphisms (SNPs) in the chromosome 19 region including apolipoprotein E (APOE) and a repeat-length polymorphism in TOMM40 (poly-T, rs10524523). 22869155

2012
dbSNP: rs10524523
rs10524523
TOMM40
0.100 GeneticVariation BEFREE Role of TOMM40 rs10524523 polymorphism in onset of alzheimer's disease caused by the PSEN1 M146L mutation. 23792692

2013
dbSNP: rs10524523
rs10524523
TOMM40
0.100 GeneticVariation BEFREE Family history (FH) of Alzheimer's disease (AD) affects mitochondrial function and may modulate effects of translocase of the outer mitochondrial membrane 40 kDa (TOMM40) rs10524523 ('523) poly-T length on memory decline. 28549947

2017
dbSNP: rs10524523
rs10524523
TOMM40
0.100 GeneticVariation BEFREE The apolipoprotein E (<i>APOE</i>) genotype and a polymorphism (rs10524523) in the translocase of outer mitochondrial membrane 40 (<i>TOMM40</i>) gene have been associated with the age of onset of AD. 29124110

2017
dbSNP: rs11556505
rs11556505
TOMM40
0.700 GeneticVariation GWASDB ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology. 24770881

2014
dbSNP: rs1160984
rs1160984
TOMM40
T 0.700 GeneticVariation GWASCAT Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk. 30617256

2019
dbSNP: rs1160985
rs1160985
TOMM40
C 0.800 GeneticVariation GWASDB SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians. 23565137

2013
dbSNP: rs1160985
rs1160985
TOMM40
C 0.800 GeneticVariation GWASCAT Genome-wide analysis of genetic predisposition to Alzheimer's disease and related sex disparities. 30636644

2019
dbSNP: rs11668327
rs11668327
TOMM40
0.700 GeneticVariation GWASCAT GWAS on family history of Alzheimer's disease. 29777097

2018
dbSNP: rs117310449
rs117310449
TOMM40
0.700 GeneticVariation GWASCAT GWAS on family history of Alzheimer's disease. 29777097

2018
dbSNP: rs141864196
rs141864196
TOMM40
A 0.700 GeneticVariation GWASCAT Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk. 30617256

2019
dbSNP: rs141864196
rs141864196
TOMM40
0.700 GeneticVariation GWASCAT GWAS on family history of Alzheimer's disease. 29777097

2018
dbSNP: rs142412517
rs142412517
TOMM40
T 0.700 GeneticVariation GWASCAT Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk. 30617256

2019
dbSNP: rs157580
rs157580
TOMM40
0.810 GeneticVariation GWASCAT Examination of the current top candidate genes for AD in a genome-wide association study. 19125160

2010