Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
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0.020 | GeneticVariation | BEFREE | The allele frequencies of the 786C/G polymorphism were 0.622 for C and 0.378 for G in AD. | 12535780 | 2003 |
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0.030 | GeneticVariation | BEFREE | This study is an attempt to clarify whether the common SNP in exon 5 of BACE1 (rs638405, Val262) is associated with a risk for late-onset AD. | 18182766 | 2008 |
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0.010 | GeneticVariation | BEFREE | Evidence for an association with AD was observed with multi-marker haplotype analyses (P = 0.01), and with rs676134 when stratified for APOE genotype (P = 0.02), however adjusting for multiple testing negated the evidence for association of this variant with AD. chi(2) analysis of genotype and allele frequencies in cases versus controls for individual SNPs revealed no evidence for association (5% level). | 18581272 | 2008 |
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0.010 | GeneticVariation | BEFREE | The impact of celastrol on brain Abeta accumulation was tested in a transgenic mouse model of AD overexpressing the human APP695sw mutation and the presenilin-1 mutation M146L (Tg PS1/APPsw) by immunostaining and ELISAs. | 20211007 | 2010 |
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0.030 | GeneticVariation | BEFREE | Our analysis demonstrated that GG genotype and G allele of BACE1 gene rs638405 probably increase the risk of AD. | 26828303 | 2016 |
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0.020 | GeneticVariation | BEFREE | However, studies investigating the association of single-nucleotide polymorphism (SNP) in exon 5 of BACE1 (rs638405, C786G, Val262) with AD are controversial. | 26828303 | 2016 |
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0.030 | GeneticVariation | BEFREE | By exclusion of three studies that </span>did not conform to Hardy-Weinberg equilibrium (HWE), our data suggested rs638405 in BACE1 was a protective factor of AD. | 26846559 | 2017 |