|
rs2251101
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We found that weak connections existed between rs4646953 (TT vs. CC: z = 2.24, p = 0.025, OR = 1.536) and AD, but no significant associations have been found between other IDE gene single nucleotide polymorphisms of rs4646953, rs2251101 and rs1544210 with AD.
|
25105907 |
2015 |
|
rs4646953
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We found that weak connections existed between rs4646953 (TT vs. CC: z = 2.24, p = 0.025, OR = 1.536) and AD, but no significant associations have been found between other IDE gene single nucleotide polymorphisms of rs4646953, rs2251101 and rs1544210 with AD.
|
25105907 |
2015 |
|
rs1887922
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The C allele of rs1887922 conferred a higher risk of AD under the dominant genetics model (adjusted p=0.001, OR=2.719, 95% CI=1.472-5.022).
|
22502914 |
2012 |
|
rs1887922
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We examined associations of three IDE polymorphisms (IDE2, rs4646953; IDE7, rs2251101 and IDE9, rs1887922) with AD, Aβ42 plasma level and T2DM risk in the longitudinal Vienna Transdanube Aging (VITA) study cohort.
|
22107728 |
2011 |
|
rs2251101
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We examined associations of three IDE polymorphisms (IDE2, rs4646953; IDE7, rs2251101 and IDE9, rs1887922) with AD, Aβ42 plasma level and T2DM risk in the longitudinal Vienna Transdanube Aging (VITA) study cohort.
|
22107728 |
2011 |
|
rs4646953
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We examined associations of three IDE polymorphisms (IDE2, rs4646953; IDE7, rs2251101 and IDE9, rs1887922) with AD, Aβ42 plasma level and T2DM risk in the longitudinal Vienna Transdanube Aging (VITA) study cohort.
|
22107728 |
2011 |
|
rs1832196
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, for the rs1832196 polymorphism, significant association with AD was found by the dominant model in overall and subgroup analysis.
|
23416320 |
2013 |
|
rs3758505
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Results suggested that rs3758505 polymorphism was unlikely to be associated with genetic susceptibility of AD based on the current published studies.
|
23416320 |
2013 |
|
rs3781239
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A single nucleotide polymorphism (SNP) in the insulin degrading enzyme gene (IDE), rs3781239, showed a significant association with AD.
|
20880607 |
2012 |
|
rs4646958
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated the association between two polymorphisms of IDE with AD in the Chinese population and found that the T/A genotype of rs4646958 had an important role in AD (adjusted p=0.007, odds ratio [OR]=2.796, 95% confidence interval [CI]=1.330-5.878), under the co-dominant genetic model.
|
22502914 |
2012 |
|
rs1219680453
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Five point mutations within the amyloid beta-protein (Abeta) sequence of the APP gene are associated with hereditary diseases which are similar or identical to Alzheimer's disease and encode: the A21G (Flemish), E22G (Arctic), E22K (Italian), E22Q (Dutch) and the D23N (Iowa) amino acid substitutions.
|
18602473 |
2008 |
|
rs1484303631
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Five point mutations within the amyloid beta-protein (Abeta) sequence of the APP gene are associated with hereditary diseases which are similar or identical to Alzheimer's disease and encode: the A21G (Flemish), E22G (Arctic), E22K (Italian), E22Q (Dutch) and the D23N (Iowa) amino acid substitutions.
|
18602473 |
2008 |