|
rs662
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The interaction between PON1 genes (rs662 and rs85460) and ApoE genes showed synergistic epistasis in altering the odds of significantly having both AD and VaD.
|
24965284 |
2014 |
|
rs662
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Case-control studies of PON1 genetic variants in Alzheimer's disease (AD) and Parkinson's disease (PD) have revealed some positive albeit inconsistent associations with 2 PON1 coding polymorphisms: Q192R (rs662) and L55M (rs854560).
|
20947215 |
2012 |
|
rs662
|
|
|
0.090 |
GeneticVariation |
BEFREE |
There was no significant association between PON1 Q192R polymorphism and AD risk in all comparison models (R vs. Q, OR=0.89, 95% CI=0.82-0.96; RR vs. QQ, OR=0.83, 95% CI=0.68-1.01; RR+RQ vs. QQ, OR=0.86, 95% CI=0.75-0.97; and RR vs. QR+QQ, OR=0.94, 95% CI=0.81-1.11).
|
22776645 |
2012 |
|
rs662
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Meta-analyses of studies in Caucasians assessing the associations between the PON1 M55L, -161C/T and Q192R SNPs and the risk of AD were performed, and no associations were found.
|
21757906 |
2011 |
|
rs662
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Polymorphisms at the paraoxonase 1 L55M and Q192R loci affect the pathophysiology of Alzheimer's disease: emphasis on the cholinergic system and beta-amyloid levels.
|
18322397 |
2008 |
|
rs662
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Our results indicate that Gln192Arg polymorphism in the PON1 gene is associated with AD, and PON1 R allele might be a protective factor for AD in a Chinese Han ethnic population.
|
16863614 |
2006 |
|
rs662
|
|
|
0.090 |
GeneticVariation |
BEFREE |
This study indicates that the 192 Q/R polymorphism of the PON-1 gene might influence responsiveness to ChEIs, with potentially important implications for the treatment of AD.
|
15925115 |
2005 |
|
rs662
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The paraoxonase (PON1) Gln192-->Arg polymorphism was examined in a group of sporadic late-onset Alzheimer's disease (AD) patients, in a group of coronary artery disease (CAD) patients, and in normal subjects.
|
12618290 |
2003 |
|
rs662
|
|
|
0.090 |
GeneticVariation |
BEFREE |
These results suggest that the human Gln-Arg 192 Q/R polymorphism of the PON-1 gene is not associated with AD in an Italian population.
|
12566597 |
2003 |
|
rs854560
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Case-control studies of PON1 genetic variants in Alzheimer's disease (AD) and Parkinson's disease (PD) have revealed some positive albeit inconsistent associations with 2 PON1 coding polymorphisms: Q192R (rs662) and L55M (rs854560).
|
20947215 |
2012 |
|
rs854560
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Conclusively, the present meta-analysis revealed that PON1 gene polymorphisms (Q192R, L55M) were unlikely to contribute to AD susceptibility.
|
22776645 |
2012 |
|
rs854560
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Meta-analyses of studies in Caucasians assessing the associations between the PON1 M55L, -161C/T and Q192R SNPs and the risk of AD were performed, and no associations were found.
|
21757906 |
2011 |
|
rs854560
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The L55M Met allele exerts an AD risk-enhancing effect only in men (P < 0.001), whereas both men and women carrying the M55M/Q192Q genotype exhibit increased survival (2.5 years, P < 0.05) and later age of onset (1.5 years, P < 0.05).
|
19863653 |
2009 |
|
rs854560
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The frequency of the M55M genotype at the PON1 L55M locus was found to be significantly increased in AD patients relative to age-matched controls (p < 0.05).
|
18322397 |
2008 |
|
rs705379
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Existing evidence indicates that the S311C polymorphism (SS genotype) and the rs705379 (the A allele and GG genotype) are associated with risk of AD in studied population.
|
28954597 |
2017 |