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rs104893877
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Cerebral inoculation of human A53T α-synuclein reduces spatial memory decline and amyloid-β aggregation in APP/PS1 transgenic mice of Alzheimer's disease.
|
30366065 |
2018 |
|
rs104893877
|
|
|
0.040 |
GeneticVariation |
BEFREE |
One of the mutant forms of alpha-synuclein (A53T) fibrillizes more rapidly in vitro than does the wild-type protein, suggesting that a correlation may exist between the rate of in vitro fibrillization and/or oligomerization and the progression of PD, analogous to the relationship between Abeta fibrillization in vitro and familial AD.
|
10704204 |
2000 |
|
rs104893877
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Analogous to a successful strategy for the production of transgenic animal models for Alzheimer's disease we generated mice expressing wildtype and the A53T mutant of human alphaSN in the nervous system under control of mouse Thy1 regulatory sequences.
|
11113617 |
2000 |
|
rs104893877
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Exploration of the possibility that the same mutation of the alpha-synuclein gene as that in familial PD (Ala53Thr) may also confer susceptibility to sporadic PD, DLB, and AD revealed the mutation in none of the samples of 329 cases and 230 controls examined, suggesting that this mutation is not involved in these neurological diseases.
|
9743579 |
1998 |
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rs356182
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In MR between α-synuclein in PD with AD risk, we only extracted rs356182 as the IV through a strict screening process.
|
30598082 |
2018 |
|
rs356182
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Here, in order to discover potential AD-related loci, we investigated the association between late-onset AD (LOAD) susceptibility and nine single-nucleotide polymorphisms (SNPs) (rs11724635 of BST1, rs12637471 of MCCC1, rs15553999 of TMEM229, rs17649553 of MAPT, rs34311866 of TMEM175-GAK-DGKQ, rs356182 of SNCA, rs6430538 of ACMSD-TMEM163, rs76904798 of LRRK2 and rs823118 of RAB7L1-NUCKS1) which were reported to have genome-wide significant associations with PD risk in a recent Genome Wide Association Study performed among white population.
|
26738859 |
2017 |
|
rs356219
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Assessments included the RBD screening questionnaire, the extended Consortium to Establish a Registry for Alzheimer's Disease test battery, and genetic testing for the risk variant rs356219 in the alpha-synuclein gene.
|
30048891 |
2018 |
|
rs10516846
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNCA gene polymorphism may be associated with an increased risk of AD and GG genotype of rs10516846 and elevated SNCA level in CSF may increase the risk of early-onset AD.
|
27184464 |
2016 |
|
rs356165
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNCA rs356165 and the MAPT H1 specific SNP rs242557 did not associate with AD or LB pathology.
|
22291217 |
2012 |