|
rs3810950
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Our findings are consistent with the results of the meta-analytical studies of the relationship between rs3810950 polymorphism and AD and provide further material evidence for a direct (primary) involvement of cholinergic mechanisms in the etiopathogenesis of AD, particularly as a factor in cognitive decline and perturbed conscious awareness commonly observed in patients with AD.
|
29759072 |
2018 |
|
rs3810950
|
|
|
0.070 |
GeneticVariation |
BEFREE |
The rs3810950G/A polymorphism had a negative effect on the risk of AD for GA or GG+GA genotypes compared with AA in the overall population or Asians.
|
27390868 |
2016 |
|
rs3810950
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Pooled results of our meta-analysis indicated CHAT rs2177369 polymorphism was correlated with decreasing AD risk in one of five genetic models (dominant: OR = 0.77, 95% CI: 0.62-0.96), while rs3810950 mutant was associated with AD development in three models (allelic: OR = 1.18, 95% CI: 1.01-1.37, homozygous: OR = 1.63, 95% CI: 1.09-2.42, and recessive: OR = 1.65, 95% CI: 1.20-2.26).
|
27597977 |
2016 |
|
rs3810950
|
|
|
0.070 |
GeneticVariation |
BEFREE |
For CHAT, rs2177369 (G>A) in whites and rs3810950 (G>A) in Asians were found to be associated with AD susceptibility.
|
27272392 |
2016 |
|
rs3810950
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Stratification by the presence of the APOE ε4 allele showed that rs3810950 AG/non-APOE ε4 carriers and rs3810950 AA/APOE ε4 carriers were associated with a lower cognitive composite score in younger elderly 73-83 years of age, similar to previous reports of association with AD.
|
21883924 |
2011 |
|
rs3810950
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Nominal allelic and genotypic associations with AD r</span>isk in the cross-sectional VITA sample were found for rs3810950 (p = 0.038 for genotype, OR = 1.66 95% CI 1.03-2.68, p = 0.052 allele-wise).
|
21507424 |
2011 |
|
rs3810950
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Previous studies have reported significant disease associations for both the K-variant of BChE and the coding ChAT rs3810950 polymorphism with AD.
|
15690550 |
2005 |
|
rs1880676
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Association of Choline Acetyltransferase Gene Polymorphisms (SNPs rs868750G/A, rs1880676G/A, rs2177369G/A and rs3810950G/A) with Alzheimer's Disease Risk: A Meta-Analysis.
|
27390868 |
2016 |
|
rs1880676
|
|
|
0.030 |
GeneticVariation |
BEFREE |
No association was detected between rs1880676 and rs868750 and AD</span> risk.
|
27272392 |
2016 |
|
rs2177369
|
|
|
0.030 |
GeneticVariation |
BEFREE |
For CHAT, rs2177369 (G>A) in whites and rs3810950 (G>A) in Asians were found to be associated with AD susceptibility.
|
27272392 |
2016 |
|
rs2177369
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Pooled results of our meta-analysis indicated CHAT rs2177</span>369 polymorphism was correlated with decreasing AD risk in one of five genetic models (dominant: OR = 0.77, 95% CI: 0.62-0.96), while rs3810950 mutant was associated with AD development in three models (allelic: OR = 1.18, 95% CI: 1.01-1.37, homozygous: OR = 1.63, 95% CI: 1.09-2.42, and recessive: OR = 1.65, 95% CI: 1.20-2.26).
|
27597977 |
2016 |
|
rs2177369
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Our meta-analysis suggested that rs1880670G/A, and rs2177369 G/A polymorphisms were not risk factors for AD.
|
27390868 |
2016 |
|
rs2177369
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Association of Choline Acetyltransferase Gene Polymorphisms (SNPs rs868750G/A, rs1880676G/A, rs2177369G/A and rs3810950G/A) with Alzheimer's Disease Risk: A Meta-Analysis.
|
27390868 |
2016 |
|
rs1880676
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Furthermore, an association of rs1880676 with AD was specific to carriers of the APOEε4 risk allele (p = 0.008, genotype; OR = 3.47 95% CI 1.50-8.01 p = 0.005 allele-wise).
|
21507424 |
2011 |
|
rs868750
|
|
|
0.020 |
GeneticVariation |
BEFREE |
No association was detected between rs1880676 and rs868750 and AD</span> risk.
|
27272392 |
2016 |
|
rs868750
|
|
|
0.020 |
GeneticVariation |
BEFREE |
However, rs3810950G/A, or rs868750G/A genetic polymorphism was a genetic risk factor for the development of AD.
|
27390868 |
2016 |
|
rs2177370
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The response to AChEIs in AD patients was significantly associated with 2 SNPs on the intronic region of CHAT rs2177370 (uncorrected P=0.0025, FDR controlled P=0.026) and rs3793790 (uncorrected P=0.0024, FDR controlled P=0.026).
|
25730470 |
2015 |
|
rs3793790
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The response to AChEIs in AD patients was significantly associated with 2 SNPs on the intronic region of CHAT rs2177370 (uncorrected P=0.0025, FDR controlled P=0.026) and rs3793790 (uncorrected P=0.0024, FDR controlled P=0.026).
|
25730470 |
2015 |
|
rs8178990
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The ChAT rs3810950 A allele, which has been associated with increased risk for AD, was found to be associated with a decrease cognitive status evaluated by a five-component cognitive composite score [P = 0.03, regression coefficient -0.30, 95% confidence interval (CI) -0.57 to -0.02], and the rs3810950 and rs8178990 ancestral GC haplotype was also associated with better cross-sectional cognitive composite score (P = 0.04, regression coefficient 0.59, 95% CI 0.03 to 1.16).
|
21883924 |
2011 |
|
rs772659997
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Associations between AD and/or depression to gene polymorphisms APO E (epsilon4), choline acetyltransferase (ChAT) 4G to A, serotonin-transporter gene promoter-length, dopamine-D4-receptor, ciliary-neurotrophic-factor-null mutation and brain-derived neurotrophic factor (C270T) and to various known factors were analyzed.
|
18603262 |
2009 |
|
rs1455460144
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Polymorphisms at the paraoxonase 1 L55M and Q192R loci affect the pathophysiology of Alzheimer's disease: emphasis on the cholinergic system and beta-amyloid levels.
|
18322397 |
2008 |
|
rs733722
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After correction for multiple testing, we found one SNP, rs733722, in a promoter region of CHAT, is associated with response of AD patients to cholinesterase inhibitors (P = 0.03) and accounts for 6% of the variance in response to AChE inhibitors.
|
16424819 |
2006 |
|
rs868749
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Because of the potential importance of this finding we analyzed this SNP and another functional SNP within exon 9 (rs868749) of the CHAT gene using a German case control sample consisting of 242 patients with AD and 143 cognitively healthy controls.
|
12770689 |
2003 |