|
rs17571
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The exon variant Aal58Val (rs17571) in CTSD was recently associated with AD, leading us to examine whether it also affects risk of ALS and PD.
|
28917980 |
2018 |
|
rs17571
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Additional search for potentially modifying variants revealed in all affected individuals of the third generation a paternally inherited variant p.A58V (rs17571) of Cathepsin D which is considered an independent risk factor for Alzheimer's disease.
|
23415546 |
2013 |
|
rs17571
|
|
|
0.080 |
GeneticVariation |
BEFREE |
A meta-analysis of previously published data showed a significantly increased risk of AD in carriers of the T-allele of rs17571 (OR 1.22, 95% CI 1.03-1.44), irrespective of APOE ε4 carrier status.
|
19926167 |
2011 |
|
rs17571
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Thus, our results support the idea that rs17571 confers an increased risk for AD in</span> men but not in women.
|
20083556 |
2010 |
|
rs17571
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Furthermore, we did not find any statistically significant differences in rates between CAT rs1001179 and CTSD rs17571 genotypes and AD controlling for APOE e4 allele status.
|
18248894 |
2008 |
|
rs17571
|
|
|
0.080 |
GeneticVariation |
BEFREE |
This study looked at a polymorphism in the cathepsin D gene (refSNP ID: rs17571) previously examined in Alzheimer's disease (AD).
|
18426579 |
2008 |
|
rs17571
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The cathepsin D rs17571 polymorphism: effects on CSF tau concentrations in Alzheimer disease.
|
16652347 |
2006 |
|
rs17571
|
|
|
0.080 |
GeneticVariation |
BEFREE |
A C224T (A38V) polymorphism in exon 2 of the CTSD gene is reported to be associated with an increased risk for AD.
|
12811635 |
2003 |
|
rs1366541089
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Variations in CTSD and MnSOD showed no association with the development of AD, whereas the presence of the Ala224Val polymorphism in CTSD had a positive association with the development of AD.
|
26351775 |
2015 |
|
rs1366541089
|
|
|
0.040 |
GeneticVariation |
BEFREE |
It has been suggested that the C-->T (224Ala-->Val) transition within exon 2 of the cathepsin D gene (CTSD) might represent a risk factor for late onset AD.
|
16543533 |
2006 |
|
rs1366541089
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Meta-analysis of the association of the cathepsin D Ala224Val gene polymorphism with the risk of Alzheimer's disease: a HuGE gene-disease association review.
|
15003956 |
2004 |
|
rs1366541089
|
|
|
0.040 |
GeneticVariation |
BEFREE |
A functional polymorphism in exon 2 of the cathepsin D gene (C-->T, Ala224Val) has recently been reported to increase the risk for AD in some of the Caucasian populations, with a significant overrepresentation of the T allele, but these reports have not been universally duplicated.
|
15211064 |
2004 |
|
rs1369330655
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A C224T (A38V) polymorphism in exon 2 of the CTSD gene is reported to be associated with an increased risk for AD.
|
12811635 |
2003 |