|
rs2230806
|
|
|
0.090 |
GeneticVariation |
BEFREE |
After correcting p values for multiple testing, only the effects of the rs2230805 and rs2230806 polymorphisms remained significant in the recessive model suggesting a modest protective effect of their minor alleles in AD, which should be interpreted with considerable caution, until further studies elucidate their role in AD pathology.
|
29133174 |
2018 |
|
rs2230806
|
|
|
0.090 |
GeneticVariation |
BEFREE |
CONCLUSIONS ABCA1 R219K R allele was the risk factor inducing abnormal serum levels of ApoA2, LDL, and TG in AD patients, and abnormal levels of serum ABCA1, HDL, IL-1b, IL-6, and TNF-α in PD patients, while ABCA1 R219K K allele was the risk factor inducing lower ABCA1 in AD patients.
|
28943632 |
2017 |
|
rs2230806
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The relationship between ABCA1 common variations (R219 K rs2230806, I883 M rs4149313 and R1587 K rs2230808) and AD has been reported in various ethnic groups; however, these studies have yielded contradictory results.
|
23111454 |
2013 |
|
rs2230806
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The results indicated that the RK genotype or K allele (RK + KK) of R219K may relate to the development of AD in the east of China.
|
22377775 |
2012 |
|
rs2230806
|
|
|
0.090 |
GeneticVariation |
BEFREE |
In summary, there was no significant association detected between ABCA1 R219K, I883M and R1587K polymorphisms and risk for AD.
|
22982414 |
2012 |
|
rs2230806
|
|
|
0.090 |
GeneticVariation |
BEFREE |
We show an apparent weak association of rs2230806 (p-value=0.01) with the disease in a sibpair series of Alzheimer's disease that had shown previously evidence for linkage to the chromosome 9 locus where ABCA1 maps.
|
17324514 |
2007 |
|
rs2230806
|
|
|
0.090 |
GeneticVariation |
BEFREE |
To evaluate the relationship between ABCA1 genetic variants and Alzheimer's disease (AD), independently or in concert with the APOE epsilon4 allele, we examined three ABCA1 polymorphisms located in the coding region (R219K, I883M, and R1587K) and two ABCA1 polymorphisms in the promoter region (C-14T and C-477T) in a group of 372 Spanish AD patients and 440 controls.
|
17510946 |
2007 |
|
rs2230806
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The purpose of this case-control study was to determine whether single nucleotide polymorphisms (SNPs) A-->G in the intron 2 of CYP46 gene and G-->A (R219K) in the exon 7 of ABCA1 gene are associated with sporadic AD in the Chinese Han population.
|
17335784 |
2007 |
|
rs2230806
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Since altered cholesterol metabolism is also involved in Alzheimer's disease (AD), the effects of two ABCA1 polymorphisms (G-395C promoter polymorphism (rs 2246293) and exonic R219K) on the risk of AD in 241 AD patients and 294 non-demented controls, and on CSF cholesterol and 24S-hydroxycholesterol in 74 AD patients and 42 non-demented controls were investigated.
|
16596262 |
2006 |
|
rs2230808
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The relationship between ABCA1 common variations (R219 K rs2230806, I883 M rs4149313 and R1587 K rs2230808) and AD has been reported in various ethnic groups; however, these studies have yielded contradictory results.
|
23111454 |
2013 |
|
rs2230808
|
|
|
0.050 |
GeneticVariation |
BEFREE |
In summary, there was no significant association detected between ABCA1 R219K, I883M and R1587K polymorphisms and risk for AD.
|
22982414 |
2012 |
|
rs2230808
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Although coding SNP (rs2230808) was confirmed to have a significant association with AD, prediction of the effects of an amino acid substitution SNP rs2230808 (R1587K) on the three-dimensional structure and function of the ABCA1 protein using PolyPhen program revealed that it is unlikely to be functionally significant.
|
17510949 |
2007 |
|
rs2230808
|
|
|
0.050 |
GeneticVariation |
BEFREE |
To evaluate the relationship between ABCA1 genetic variants and Alzheimer's disease (AD), independently or in concert with the APOE epsilon4 allele, we examined three ABCA1 polymorphisms located in the coding region (R219K, I883M, and R1587K) and two ABCA1 polymorphisms in the promoter region (C-14T and C-477T) in a group of 372 Spanish AD patients and 440 controls.
|
17510946 |
2007 |
|
rs2230808
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Rs2234884 and another non-synonymous SNP (R1587K) in ABCA1 (rs2234886) failed to show significant association with the risk for AD.
|
12600718 |
2003 |
|
rs2066714
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In summary, there was no significant association detected between ABCA1 R219K, I883M and R1587K polymorphisms and risk for AD.
|
22982414 |
2012 |
|
rs2066714
|
|
|
0.020 |
GeneticVariation |
BEFREE |
To evaluate the relationship between ABCA1 genetic variants and Alzheimer's disease (AD), independently or in concert with the APOE epsilon4 allele, we examined three ABCA1 polymorphisms located in the coding region (R219K, I883M, and R1587K) and two ABCA1 polymorphisms in the promoter region (C-14T and C-477T) in a group of 372 Spanish AD patients and 440 controls.
|
17510946 |
2007 |
|
rs2230805
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After correcting p values for multiple testing, only the effects of the rs2230805 and rs2230806 polymorphisms remained significant in the recessive model suggesting a modest protective effect of their minor alleles in AD, which should be interpreted with considerable caution, until further studies elucidate their role in AD pathology.
|
29133174 |
2018 |
|
rs1800977
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, ABCA1 rs2066718 and rs1800977 polymorphisms might not contribute to AD susceptibility in general population, but they should play a role on AD development when interacted with ApoE-ε4.
|
27215623 |
2016 |
|
rs2066718
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, ABCA1 rs2066718 and rs1800977 polymorphisms might not contribute to AD susceptibility in general population, but they should play a role on AD development when interacted with ApoE-ε4.
|
27215623 |
2016 |
|
rs2422493
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In summary, our meta-analysis results showed that ABCA1 rs2422493 polymorphism was a risk factor for AD while PTGS2 rs20417 variant showed a protective effect on AD risk.
|
27215623 |
2016 |
|
rs146292819
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Multifactorially adjusted hazard ratios for N1800H AC versus AA were 4.13 (95% confidence interval, 1.32-12.9) for AD, 2.46 (1.10-5.50) for cerebrovascular disease, and 8.28 (2.03-33.7) for the hemorrhagic stroke subtype.
|
26079414 |
2015 |
|
rs4149313
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The relationship between ABCA1 common variations (R219 K rs2230806, I883 M rs4149313 and R1587 K rs2230808) and AD has been reported in various ethnic groups; however, these studies have yielded contradictory results.
|
23111454 |
2013 |
|
rs2066715
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We studied the role of R219K and V825I polymorphisms of ABCA1 in modulating the risk of AD in 321 AD patients and 349 comparisons of Chinese Han.
|
22377775 |
2012 |
|
rs2740483
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the present study, we examined the role of two ABCA1 polymorphisms, R219K (rs2230806) and G-17C (rs2740483) in modifying the risk of late-onset AD (LOAD) in a large American white cohort of 992 AD cases and 699 controls.
|
16725228 |
2007 |
|
rs2234886
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Rs2234884 and another non-synonymous SNP (R1587K) in ABCA1 (rs2234886) failed to show significant association with the risk for AD.
|
12600718 |
2003 |