| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
|
0.020 | GeneticVariation | BEFREE | This meta-analysis indicates that rs3736187 (A/G) polymorphisms may be a potential beneficial single nucleotide polymorphism (SNP), which are associated with a decreased risk in AD. | 25125048 | 2014 |
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0.020 | GeneticVariation | BEFREE | The pooled odds ratio (OR) and confidence interval (CI) suggested that rs989692 polymorphisms were not associated with AD based on the current published studies (C vs. T, OR = 1.01, 95% CI = 0.85-1.19; CC+TT vs. CT, OR = 0.89, 95% CI = 0.78-1.01). | 25125048 | 2014 |
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|
0.020 | GeneticVariation | BEFREE | Two SNPs, rs989692 and rs3736187, had significantly different allelic and genotypic frequencies (uncorrected p = 0.01) between the AD and the control subjects and haplotype analysis showed significant association between AD and NEP polymorphisms. | 15548496 | 2004 |
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|
0.020 | GeneticVariation | BEFREE | Two SNPs, rs989692 and rs3736187, had significantly different allelic and genotypic frequencies (uncorrected p = 0.01) between the AD and the control subjects and haplotype analysis showed significant association between AD and NEP polymorphisms. | 15548496 | 2004 |
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|
0.010 | GeneticVariation | BEFREE | SNP rs1816558 of NEP was found to be significantly associated with AD after adjustment for ε4 allele of the apolipoprotein E gene (APOEε4) and the Bonferroni correction. | 26362309 | 2016 |
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0.010 | GeneticVariation | BEFREE | Five point mutations within the amyloid beta-protein (Abeta) sequence of the APP gene are associated with hereditary diseases which are similar or identical to Alzheimer's disease and encode: the A21G (Flemish), E22G (Arctic), E22K (Italian), E22Q (Dutch) and the D23N (Iowa) amino acid substitutions. | 18602473 | 2008 |
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0.010 | GeneticVariation | BEFREE | SNP rs1836915, in linkage disequilibrium block 2, showed the greatest extent of genotypic association with AD (p=0.0076). | 17928142 | 2007 |