Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1008459
rs1008459
KIAA0040
0.700 GeneticVariation GWASDB Genome-wide genotyping in amyotrophic lateral sclerosis and neurologically normal controls: first stage analysis and public release of data. 17362836

2007
dbSNP: rs10122902
rs10122902
C9orf72
G 0.800 GeneticVariation GWASCAT Chromosome 9p21 in sporadic amyotrophic lateral sclerosis in the UK and seven other countries: a genome-wide association study. 20801717

2010
dbSNP: rs10122902
rs10122902
C9orf72
0.800 GeneticVariation GWASDB Chromosome 9p21 in sporadic amyotrophic lateral sclerosis in the UK and seven other countries: a genome-wide association study. 20801717

2010
dbSNP: rs10139154
rs10139154
SCFD1
0.720 GeneticVariation BEFREE Sec1 family domain-containing protein 1 (SCFD1) gene polymorphism rs10139154 has recently been implicated in the risk of developing amyotrophic lateral sclerosis (ALS). 31267315

2019
dbSNP: rs10139154
rs10139154
SCFD1
0.720 GeneticVariation BEFREE Our results suggest that there is a lack of association of SCFD1 rs10139154 with the risk for ALS in a large Chinese population, but this variant may modulate the age of onset of ALS. 29260601

2018
dbSNP: rs10139154
rs10139154
SCFD1
0.720 GeneticVariation GWASCAT Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis. 27455348

2016
dbSNP: rs10139154
rs10139154
SCFD1
0.720 GeneticVariation GWASCAT Genome-wide Analyses Identify KIF5A as a Novel ALS Gene. 29566793

2018
dbSNP: rs10143310
rs10143310
ATXN3
0.700 GeneticVariation GWASCAT Genome-wide Analyses Identify KIF5A as a Novel ALS Gene. 29566793

2018
dbSNP: rs10260404
rs10260404
DPP6
0.820 GeneticVariation BEFREE We have attempted to replicate a recently reported association of polymorphism rs10260404, in the Dipeptidyl-peptidase 6 gene (DPP6), with susceptibility to amyotrophic lateral sclerosis (ALS) in a large independent Italian cohort of 904 cases and 1036 controls. 19525032

2011
dbSNP: rs10260404
rs10260404
DPP6
C 0.820 GeneticVariation GWASDB Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis. 18084291

2008
dbSNP: rs10260404
rs10260404
DPP6
C 0.820 GeneticVariation GWASCAT Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis. 18084291

2008
dbSNP: rs10260404
rs10260404
DPP6
0.820 GeneticVariation BEFREE The rs10260404 is not associated with ALS susceptibility in Chinese people with Han origin which may be due to ethnic differences. 20137488

2009
dbSNP: rs1032968973
rs1032968973
INSRR ; NTRK1
0.020 GeneticVariation BEFREE In this study, for the first time, we adopted a method involving the intranasal administration of nerve growth factor combined with lateral ventricle NSC transplantation using G93A-SOD1 transgenic mice as experimental subjects to explore the treatment effect of this combined therapy in ALS. 28694091

2017
dbSNP: rs1032968973
rs1032968973
INSRR ; NTRK1
0.020 GeneticVariation BEFREE In the SOD1(G93A) mutant rat model of amyotrophic lateral sclerosis (ALS), neuronal death and rapid paralysis progression are associated with the emergence of activated aberrant glial cells that proliferate in the degenerating spinal cord. 27400786

2016
dbSNP: rs10438933
rs10438933
B4GALT6
G 0.800 GeneticVariation GWASCAT Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis. 19451621

2009
dbSNP: rs10438933
rs10438933
B4GALT6
G 0.800 GeneticVariation GWASDB Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis. 19451621

2009
dbSNP: rs10463311
rs10463311
TNIP1
0.710 GeneticVariation BEFREE We find a significant association of rs10463311 spanning GPX3-TNIP1 with ALS (p = 1.3 × 10<sup>-8</sup>), with replication support from two independent Australian samples (combined 576 cases and 683 controls, p = 1.7 × 10<sup>-3</sup>). 28931804

2017
dbSNP: rs10463311
rs10463311
TNIP1
0.710 GeneticVariation GWASCAT Genome-wide Analyses Identify KIF5A as a Novel ALS Gene. 29566793

2018
dbSNP: rs104893941
rs104893941
SQSTM1 ; MRNIP
0.010 GeneticVariation BEFREE Genetic analysis showed a heterozygous mutation in <i>TARDBP</i> (p.A390S) and in <i>SQSTM1</i> (p.P392L), both previously described as causing amyotrophic lateral sclerosis. 30889971

2019
dbSNP: rs10511816
rs10511816
MOB3B
0.700 GeneticVariation GWASDB Residual association at C9orf72 suggests an alternative amyotrophic lateral sclerosis-causing hexanucleotide repeat. 23587638

2013
dbSNP: rs1053983726
rs1053983726
PTAFR
0.010 GeneticVariation BEFREE PAFR is overexpressed, as compared to age matched controls, in the spinal cords of transgenic ALS SOD1-G93A mice, suggesting PAF mediation. 29472887

2018
dbSNP: rs1054281443
rs1054281443
NUP98
0.010 GeneticVariation BEFREE ADAR2 deficiency can occur in ALS patients with a FUS(P525L) mutation and is unrelated to the presence of FUS-positive inclusions. 27343041

2016
dbSNP: rs10757665
rs10757665
C9orf72
0.700 GeneticVariation GWASDB Residual association at C9orf72 suggests an alternative amyotrophic lateral sclerosis-causing hexanucleotide repeat. 23587638

2013
dbSNP: rs10812605
rs10812605
MOB3B
0.700 GeneticVariation GWASDB Residual association at C9orf72 suggests an alternative amyotrophic lateral sclerosis-causing hexanucleotide repeat. 23587638

2013
dbSNP: rs10812611
rs10812611
C9orf72 ; LOC107987057
0.700 GeneticVariation GWASDB Residual association at C9orf72 suggests an alternative amyotrophic lateral sclerosis-causing hexanucleotide repeat. 23587638

2013