|
rs12762549
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The risk of anemia was increased for variant alleles of rs1128503 (ABCB1, C > T; p = 0.023, OR = 1.71, 95% CI = 1.07-2.71), rs363717 (ABCA1, A > G; p = 0.002, OR = 2.08, 95% CI = 1.32-3.27) and rs11615 (ERCC1, T > C; p = 0.031, OR = 1.61, 95% CI = 1.04-2.50), while it was decreased for variant alleles of rs12762549 (ABCC2, C > G; p = 0.004, OR = 0.51, 95% CI = 0.33-0.81).
|
25881102 |
2015 |
|
rs13194491
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The risk of developing anaemia is increased in reproductive age women carriers of A allele of rs1868505 (CACNA2D3) and/or T allele of rs13194491 (HIST1H2BJ).
|
26460247 |
2015 |
|
rs3024505
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In contrast, CD patients carrying C allele of rs3024505 had significantly increased risk of anemia and stricturing/penetrating behavior.
|
27558476 |
2016 |
|
rs8099917
|
|
|
0.010 |
GeneticVariation |
BEFREE |
ITPA rs1127354 is useful for the prediction of ribavirin-induced anemia in the early phase after the commencement of peginterferon plus ribavirin treatment and IL28B rs8099917 is useful for the prediction of sustained virological response.
|
23012624 |
2012 |
|
rs363717
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The risk of anemia was increased for variant alleles of rs1128503 (ABCB1, C > T; p = 0.023, OR = 1.71, 95% CI = 1.07-2.71), rs363717 (ABCA1, A > G; p = 0.002, OR = 2.08, 95% CI = 1.32-3.27) and rs11615 (ERCC1, T > C; p = 0.031, OR = 1.61, 95% CI = 1.04-2.50), while it was decreased for variant alleles of rs12762549 (ABCC2, C > G; p = 0.004, OR = 0.51, 95% CI = 0.33-0.81).
|
25881102 |
2015 |
|
rs1045642
|
|
|
0.010 |
GeneticVariation |
BEFREE |
On evaluating higher order gene-gene interaction models by MDR analysis, CYP3A5*3; ABCB11236C>T and ABCB1 2677G>T/A; ABCB1 3435C>T and CYP1B1*3 showed significant association with treatment response, grade 2-4 anemia and dose delay/reduction due to neutropenia (P=0.024, P=0.004, P=0.026), respectively.
|
24704000 |
2014 |
|
rs1128503
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The risk of anemia was increased for variant alleles of rs1128503 (ABCB1, C > T; p = 0.023, OR = 1.71, 95% CI = 1.07-2.71), rs363717 (ABCA1, A > G; p = 0.002, OR = 2.08, 95% CI = 1.32-3.27) and rs11615 (ERCC1, T > C; p = 0.031, OR = 1.61, 95% CI = 1.04-2.50), while it was decreased for variant alleles of rs12762549 (ABCC2, C > G; p = 0.004, OR = 0.51, 95% CI = 0.33-0.81).
|
25881102 |
2015 |
|
rs2032582
|
|
|
0.010 |
GeneticVariation |
BEFREE |
On evaluating higher order gene-gene interaction models by MDR analysis, CYP3A5*3; ABCB11236C>T and ABCB1 2677G>T/A; ABCB1 3435C>T and CYP1B1*3 showed significant association with treatment response, grade 2-4 anemia and dose delay/reduction due to neutropenia (P=0.024, P=0.004, P=0.026), respectively.
|
24704000 |
2014 |
|
rs866082104
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Hemopoietic-specific Sf3b1-K700E knock-in mice display the splicing defect seen in human MDS but develop anemia without ring sideroblasts.
|
27604819 |
2017 |
|
rs373533
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Meanwhile, individuals with the EMR1 rs373533 GT, EMR1 rs461645 CT and RTN3 rs542998 (additive C) genotypes were more susceptible to hyperpyrexia while both females and males with the rs1050828 and rs1050829 SNPs of G6PD, respectively, were more vulnerable to anaemia.
|
24934404 |
2014 |
|
rs461645
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Meanwhile, individuals with the EMR1 rs373533 GT, EMR1 rs461645 CT and RTN3 rs542998 (additive C) genotypes were more susceptible to hyperpyrexia while both females and males with the rs1050828 and rs1050829 SNPs of G6PD, respectively, were more vulnerable to anaemia.
|
24934404 |
2014 |
|
rs1554544862
|
|
C |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs662799
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Polymorphisms of the genes MTHFR (rs1801133) and APOA5 (rs662799), as well as anemia, are independent risk factors for stroke in Mexicans, together with traditional cardiovascular risk factors such as high triglycerides and high blood pressure.
|
29398535 |
2018 |
|
rs2245214
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The variant allele of rs6568431 SNP was more present in patients with anemia (OR = 1.86, p = 0.009) and renal involvement (OR = 1.63, p = 0.06), while the variant allele of rs2245214 SNP was significantly associated with a higher risk of producing anti-DNA autoantibodies (OR = 1.66, p = 0.04).
|
29759048 |
2018 |
|
rs6568431
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The variant allele of rs6568431 SNP was more present in patients with anemia (OR = 1.86, p = 0.009) and renal involvement (OR = 1.63, p = 0.06), while the variant allele of rs2245214 SNP was significantly associated with a higher risk of producing anti-DNA autoantibodies (OR = 1.66, p = 0.04).
|
29759048 |
2018 |
|
rs6051702
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Baseline testing of rs6051702 may identify the subset of patients at greatest risk for RBV-induced anaemia using interferon-free hepatitis C therapies.
|
28198349 |
2017 |
|
rs6051702
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Polymorphisms of inosine triphosphate pyrophosphatase (rs1127354 and rs6051702) and interferon lambda 4 (IFLN4) (rs12979860) are indicators of anemia and/or sustained virological response (SVR) in patients with chronic hepatitis C on ribavirin/interferon.
|
31359493 |
2020 |
|
rs6051702
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The ITPA rs1127354 CC and rs6051702 AA genotypes may predict ribavirin-induced anemia during treatment with interferon-free, ribavirin-containing regimens.
|
26650626 |
2015 |
|
rs6051702
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In multivariate logistic regression analyses the carrier of a variant allele in the rs6051702/rs1127354 association (OR=0.11, p=1.75×10(-5)) and Hb at baseline (OR=1.51, p=1.21×10(-4)) were independently associated with protection against clinically significant anemia at week 4.
|
23933495 |
2013 |
|
rs1375515
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Novel SNP rs1375515, located in a subunit of the calcium channel gene CACNA2D3, is associated with a higher risk of anaemia.
|
26460247 |
2015 |
|
rs1868505
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The risk of developing anaemia is increased in reproductive age women carriers of A allele of rs1868505 (CACNA2D3) and/or T allele of rs13194491 (HIST1H2BJ).
|
26460247 |
2015 |
|
rs1934951
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Regarding paclitaxel toxicity: CYP2C8 HapC and CYP2C8 rs1934951 were associated with anemia; and ERCC1 Gln504Lys with neuropathy (p≤0.01).
|
25495407 |
2014 |
|
rs41518645
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Non-synonymous substitutions (F33 L and D171N) and Indel mutations were observed for Cytochrome B gene, leading to a truncated protein, where anemia, malfunctioning of most of the vital organs as liver, kidney and mineral status was observed and debility with exercise intolerance and cardiomyopathy in extreme cases were depicted.
|
30660753 |
2019 |
|
rs1114167422
|
|
G |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs1617640
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the present study, we investigated the associations between anemia and polymorphisms in EPO promoter (rs1617640), TNF-α G-308A and ACE Insertion/Deletion in Chinese patients with type 2 diabetes.
|
25656761 |
2015 |