Source: BEFREE ×
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE The BDNF Val66Met gene polymorphism is associated with increased alexithymic and anticipatory anxiety in patients with panic disorder. 30269521

2019

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Interactive genetic association with anxiety was observed such that effects of 5-HTTLPR depended on the BDNF Val66Met polymorphism (rs6265 variant), with higher anxiety scores in short and Met carriers compared to the other allelic groups. 30711709

2019

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE The aim of the present case-control study was to explore the association between BDNF Val66Met (rs6265) polymorphism and generalized anxiety disorder in Mexican individuals, and whether this polymorphism plays a role in the symptomatology of anxiety.A total of 212 subjects were included in the study. 30882674

2019

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The BDNF Val66Met gene polymorphism is associated with increased alexithymic and anticipatory anxiety in patients with panic disorder. 30269521

2019

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Interactive genetic association with anxiety was observed such that effects of 5-HTTLPR depended on the BDNF Val66Met polymorphism (rs6265 variant), with higher anxiety scores in short and Met carriers compared to the other allelic groups. 30711709

2019

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The aim of the present case-control study was to explore the association between BDNF Val66Met (rs6265) polymorphism and generalized anxiety disorder in Mexican individuals, and whether this polymorphism plays a role in the symptomatology of anxiety.A total of 212 subjects were included in the study. 30882674

2019

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Effect of Early-Life Fluoxetine on Anxiety-Like Behaviors in BDNF Val66Met Mice. 29084453

2017

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Furthermore, we found a moderating influence of rs6265 genotype such that the association between trait anxiety and right amygdala-vPFC pathway FA was strongest in women carrying the Met allele, which is linked with decreased activity-dependent neuroplasticity. 28887539

2017

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE In the child-only analysis, multiple SNPs showed nominal evidence of relationships with phenotypes of interest. rs6265 BDNF and rs2941026 cholecystokinin B receptor had possible relationships with trait anxiety in child-only and family-based analyses. 28413930

2017

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Effect of Early-Life Fluoxetine on Anxiety-Like Behaviors in BDNF Val66Met Mice. 29084453

2017

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE On the contrary, BDNF met allele carriers showed a reduced acoustic startle response which reached significance in most samples (N1: p=0.004; N2: p=0.045; N3: n.s., N4: p=0.043) pointing to differential effects of BDNF val(66)met on distinct endophenotypes of anxiety and stress-related responses. 26773399

2016

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE On the contrary, BDNF met allele carriers showed a reduced acoustic startle response which reached significance in most samples (N1: p=0.004; N2: p=0.045; N3: n.s., N4: p=0.043) pointing to differential effects of BDNF val(66)met on distinct endophenotypes of anxiety and stress-related responses. 26773399

2016

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism influences the association of the methylome with maternal anxiety and neonatal brain volumes. 25640836

2015

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE We aimed to explore whether anxiety in BD offspring was associated with the BDNF Val66Met polymorphism.64 BD offspring (mean age: 13.73 (S.D. 25498133

2015

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE We investigated the effect of brain-derived neurotrophic factor (BDNF) Val(66)Met polymorphism on the severity of depressive and anxiety symptoms in never-smokers, former smokers, non-dependent, and nicotine-dependent smokers with a current diagnosis of depression and/or anxiety. 25618300

2015

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE BDNF Val66Met, stress, and positive mothering: Differential susceptibility model of adolescent trait anxiety. 26119141

2015

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Here we comprehensively review the role and relevance of the Val66Met polymorphism in psychiatric disorders, with emphasis on suicidal behavior and anxiety, eating, mood and psychotic disorders. 25824305

2015

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Here we comprehensively review the role and relevance of the Val66Met polymorphism in psychiatric disorders, with emphasis on suicidal behavior and anxiety, eating, mood and psychotic disorders. 25824305

2015

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism influences the association of the methylome with maternal anxiety and neonatal brain volumes. 25640836

2015

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE BDNF Val66Met, stress, and positive mothering: Differential susceptibility model of adolescent trait anxiety. 26119141

2015

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE We aimed to explore whether anxiety in BD offspring was associated with the BDNF Val66Met polymorphism.64 BD offspring (mean age: 13.73 (S.D. 25498133

2015

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE We investigated the effect of brain-derived neurotrophic factor (BDNF) Val(66)Met polymorphism on the severity of depressive and anxiety symptoms in never-smokers, former smokers, non-dependent, and nicotine-dependent smokers with a current diagnosis of depression and/or anxiety. 25618300

2015

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE The Association of BDNF Val66Met Polymorphism With Trait Anxiety in Panic Disorder. 26037856

2014

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The Association of BDNF Val66Met Polymorphism With Trait Anxiety in Panic Disorder. 26037856

2014

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE In this work, we review the literature focused on the BDNF Val(66)Met polymorphism and anxiety, and discuss biological findings from animal models to clinical studies. 24051499

2013