|
rs2228145
|
|
A |
0.850 |
GeneticVariation |
GWASCAT |
Genetic influences on susceptibility to rheumatoid arthritis in African-Americans.
|
30423114 |
2019 |
|
rs2228145
|
|
|
0.850 |
GeneticVariation |
BEFREE |
The recent meta-analysis of GWAS has expanded the total number of RA-associated loci to more than 100, out of which approximately ∼97% (98 variants) loci are located in non-coding regions, and the other ∼3% (3 variants) are in three different non-HLA genes, i.e., TYK2 (Prp1104Ala), IL6R (Asp358Ala), and PTPN22 (Trp620Arg).
|
30899276 |
2019 |
|
rs2228145
|
|
A |
0.850 |
GeneticVariation |
GWASCAT |
High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci.
|
24532676 |
2015 |
|
rs2228145
|
|
A |
0.850 |
GeneticVariation |
GWASCAT |
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
|
24390342 |
2014 |
|
rs2228145
|
|
|
0.850 |
GeneticVariation |
BEFREE |
Interleukin-6-receptor polymorphisms rs12083537, rs2228145, and rs4329505 as predictors of response to tocilizumab in rheumatoid arthritis.
|
24978393 |
2014 |
|
rs2228145
|
|
A |
0.850 |
GeneticVariation |
GWASDB |
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
|
24390342 |
2014 |
|
rs2228145
|
|
|
0.850 |
GeneticVariation |
BEFREE |
Although a common, non-synonymous variant in the IL-6 receptor gene (IL6R Asp358Ala; rs2228145 A>C) is associated with the risk of several common diseases, with the 358Ala allele conferring protection from coronary heart disease (CHD), rheumatoid arthritis (RA), atrial fibrillation (AF), abdominal aortic aneurysm (AAA), and increased susceptibility to asthma, the variant's effect on IL-6 signaling is not known.
|
23593036 |
2013 |
|
rs2228145
|
|
|
0.850 |
GeneticVariation |
GWASDB |
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
|
23143596 |
2012 |
|
rs2228145
|
|
|
0.850 |
GeneticVariation |
BEFREE |
In conclusion, our results do not confirm an association of IL6R rs2228145 and IL6ST/gp130 rs2228044 polymorphisms with CV disease in RA.
|
21981268 |
2011 |
|
rs2228145
|
|
|
0.850 |
GeneticVariation |
BEFREE |
An association between disease status and the sIL-6R rs8192284 (A358D) variant was tested in 965 patients with RA and 988 unrelated healthy controls.
|
19713205 |
2010 |
|
rs8192284
|
|
|
0.730 |
GeneticVariation |
GWASCAT |
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
|
23143596 |
2012 |
|
rs8192284
|
|
|
0.730 |
GeneticVariation |
BEFREE |
Plasma soluble IL-6 receptor concentration in rheumatoid arthritis: associations with the rs8192284 IL6R polymorphism and with disease activity.
|
20661738 |
2011 |
|
rs8192284
|
|
|
0.730 |
GeneticVariation |
BEFREE |
An association between disease status and the sIL-6R rs8192284 (A358D) variant was tested in 965 patients with RA and 988 unrelated healthy controls.
|
19713205 |
2010 |
|
rs8192284
|
|
|
0.730 |
GeneticVariation |
BEFREE |
The anti-CCP status in patients with RA determines the association between the IL6R rs8192284 polymorphism and disease activity.
|
20551110 |
2010 |
|
rs4453032
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the discovery group we found a highly significant association between IL6R SNP rs4845618 and the level of joint destruction in RA (P = 0.0058, P corrected = 0.026), and a moderate association with SNP rs4453032 (P = 0.02, P corrected = 0.05).
|
26336855 |
2015 |
|
rs4845618
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the discovery group we found a highly significant association between IL6R SNP rs4845618 and the level of joint destruction in RA (P = 0.0058, P corrected = 0.026), and a moderate association with SNP rs4453032 (P = 0.02, P corrected = 0.05).
|
26336855 |
2015 |
|
rs4329505
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Interleukin-6-receptor polymorphisms rs12083537, rs2228145, and rs4329505 as predictors of response to tocilizumab in rheumatoid arthritis.
|
24978393 |
2014 |