| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
|
0.060 | GeneticVariation | BEFREE | We found no association between the PON1 Q192R and L55M polymorphisms and susceptibility to RA, while PON1 Q192R polymorphism was associated with PON1 activity in RA patients; we found significantly lower PON1 activity in RA patients.Key points• PON1 Q192R polymorphism is associated with PON1 activity in RA patients..• PON1 activity is significantly lower in RA patients.. | 30868319 | 2019 |
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|
0.060 | GeneticVariation | BEFREE | No significant differences were found related to distributions of rs662 genotypes in RA patients compared to healthy controls. | 30588556 | 2019 |
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|
0.060 | GeneticVariation | BEFREE | PON-1 activity is impaired in RA in association with the rs662 genotype and anti-HDL antibodies, the latter being recognized as a pivotal player in the link between rs662 and CVD in patients with RA. | 26815637 | 2016 |
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|
0.060 | GeneticVariation | BEFREE | We found that PON-1-Q192R was associated with severity of RA [remission-to-low and moderate-to-high in dominant Q/Q+Q/R vs. R/R: OR=2.27, p<0.001; codominant Q/Q vs. R/R: OR=1.65, p<0.001 and Q/R vs. R/R: OR=2.12, p=0.003; recessive Q/Q vs. R/R+Q/R: OR=1.79, p=0.032; and allele Q vs. R: OR=1.68, p<0.001] and presence of anti-CCP-antibody (codominant model Q/Q vs. R/R: OR=1.28, p=0.042). | 25179377 | 2015 |
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|
0.060 | GeneticVariation | BEFREE | Till now, the relationship between the rheumatoid factor (RF) and anti-CCP-2 Ab, anti-oxidant activity and polymorphism of paraoxenase-1 (PON-1) 192 Q/R in patients with RA has not been investigated. | 25406539 | 2014 |
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0.060 | GeneticVariation | BEFREE | PON1 Q192R polymorphism was not found to be correlated with increased risk for rheumatoid arthritis in this Iranian population. | 20198589 | 2010 |
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|
0.030 | GeneticVariation | BEFREE | Association between activity and genotypes of paraoxonase1 L<sub>55</sub>M (rs854560) increases the disease activity of rheumatoid arthritis through oxidative stress. | 30506510 | 2019 |
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|
0.030 | GeneticVariation | BEFREE | We found no association between the PON1 Q192R and L55M polymorphisms and susceptibility to RA, while PON1 Q192R polymorphism was associated with PON1 activity in RA patients; we found significantly lower PON1 activity in RA patients.Key points• PON1 Q192R polymorphism is associated with PON1 activity in RA patients..• PON1 activity is significantly lower in RA patients.. | 30868319 | 2019 |
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|
0.030 | GeneticVariation | BEFREE | The L55M polymorphism of paraoxonase-1 is a risk factor for rheumatoid arthritis. | 20812194 | 2010 |