Gene: CD40 ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs4810485
rs4810485
CD40
0.840 GeneticVariation BEFREE These results suggest that the CD40 SNPs rs1883832 and rs4810485 are not RA susceptibility markers in the western Mexican population. 27813548

2016
dbSNP: rs4810485
rs4810485
CD40
0.840 GeneticVariation BEFREE Our meta-analyses confirm that the CD40 rs4810485 G/T polymorphism is associated with susceptibility to RA and SLE in Europeans. 25908480

2015
dbSNP: rs4810485
rs4810485
CD40
0.840 GeneticVariation GWASCAT High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. 23143596

2012
dbSNP: rs4810485
rs4810485
CD40
0.840 GeneticVariation GWASDB High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. 23143596

2012
dbSNP: rs4810485
rs4810485
CD40
T 0.840 GeneticVariation GWASCAT Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. 20453842

2010
dbSNP: rs4810485
rs4810485
CD40
T 0.840 GeneticVariation GWASDB Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. 20453842

2010
dbSNP: rs4810485
rs4810485
CD40
0.840 GeneticVariation BEFREE Eight markers (ie, rs1160542 (AFF3), rs1678542 (KIF5A), rs2476601 (PTPN22), rs3087243 (CTLA4), rs4810485 (CD40), rs5029937 (6q23), rs10760130 (TRAF1/C5) and rs7574865 (STAT4)) were significantly associated with RA by meta-analysis. 20498205

2010
dbSNP: rs4810485
rs4810485
CD40
0.840 GeneticVariation BEFREE The TT and CC/CG genotypes of 2 single-nucleotide polymorphisms, rs4810485 (CD40) and rs42041 (CDK6), respectively, were associated with a higher rate of joint destruction in ACPA-positive RA patients (P=0.003 and P=0.012, respectively), with rs4810485 being significant after Bonferroni correction for multiple testing. 19644859

2009
dbSNP: rs4810485
rs4810485
CD40
G 0.840 GeneticVariation GWASCAT Common variants at CD40 and other loci confer risk of rheumatoid arthritis. 18794853

2008
dbSNP: rs4810485
rs4810485
CD40
G 0.840 GeneticVariation GWASDB Common variants at CD40 and other loci confer risk of rheumatoid arthritis. 18794853

2008
dbSNP: rs4239702
rs4239702
CD40
T 0.800 GeneticVariation GWASCAT Genetic influences on susceptibility to rheumatoid arthritis in African-Americans. 30423114

2019
dbSNP: rs4239702
rs4239702
CD40
C 0.800 GeneticVariation GWASDB Genetics of rheumatoid arthritis contributes to biology and drug discovery. 24390342

2014
dbSNP: rs4239702
rs4239702
CD40
C 0.800 GeneticVariation GWASCAT Genetics of rheumatoid arthritis contributes to biology and drug discovery. 24390342

2014
dbSNP: rs1883832
rs1883832
CD40
0.730 GeneticVariation BEFREE CD40 rs1883832 is associated with decreased risk of Graves' disease, especially in Asian; CD40 rs1883832 is associated with increased risk of multiple sclerosis; CD40 -1C>T (rs1883832) is not associated with the susceptibility of Hashimoto's thyroiditis, systemic sclerosis or Asthma; there is insufficient data to fully confirm the association between CD40 rs1883832 and systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Behçet's disease (BD), myasthenia gravis (MG), Crohn's disease (CD), ulcerative colitis (UC), Sarcoidosis, Fuch uveitis syndrome (FUS), Vogt-Koyanagi-Harada syndrome (VKH), Kawasaki disease (KD), giant cell arteritis (GCA) or Immune thrombocytopenia (ITP). 29254239

2017
dbSNP: rs1883832
rs1883832
CD40
0.730 GeneticVariation BEFREE These results suggest that the CD40 SNPs rs1883832 and rs4810485 are not RA susceptibility markers in the western Mexican population. 27813548

2016
dbSNP: rs1883832
rs1883832
CD40
G 0.730 GeneticVariation GWASCAT High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci. 24532676

2015
dbSNP: rs1883832
rs1883832
CD40
0.730 GeneticVariation BEFREE Data from our pilot study indicate a potential association of rs1883832 CD40 gene polymorphism with susceptibility to RA. 23166616

2012
dbSNP: rs1535045
rs1535045
CD40
0.010 GeneticVariation BEFREE Also, the CD40 rs1535045 gene variant may influence development of subclinical atherosclerosis in RA patients. 23166616

2012
dbSNP: rs772829518
rs772829518
CD40
0.010 GeneticVariation BEFREE Their peripheral blood mononuclear cells (PBMC) had increased basal NF-kappaB activation compared with healthy controls and also had increased p50 nuclear expression following tumour necrosis factor (TNF) stimulation compared with PBMC from healthy controls, as well as T50M (T79M) and C88R (C117R) patients with TRAPS and patients with rheumatoid arthritis (RA). 18086728

2008