Gene: STAT6 ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1059513
rs1059513
NAB2 ; STAT6
T 0.700 GeneticVariation GWASCAT Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct. 30929738

2019
dbSNP: rs201011002
rs201011002
STAT6
T 0.700 GeneticVariation GWASCAT Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis. 31619474

2019
dbSNP: rs3122929
rs3122929
STAT6
T 0.700 GeneticVariation GWASCAT Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations. 30787307

2019
dbSNP: rs3122929
rs3122929
STAT6
T 0.700 GeneticVariation GWASCAT Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct. 30929738

2019
dbSNP: rs3122929
rs3122929
STAT6
T 0.700 GeneticVariation GWASCAT Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis. 31619474

2019
dbSNP: rs703816
rs703816
STAT6
C 0.700 GeneticVariation GWASCAT Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study. 30552067

2019
dbSNP: rs1059513
rs1059513
NAB2 ; STAT6
0.700 GeneticVariation GWASCAT A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases. 29785011

2018
dbSNP: rs167769
rs167769
STAT6
T 0.700 GeneticVariation GWASCAT Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks. 29273806

2018
dbSNP: rs3024971
rs3024971
STAT6
0.700 GeneticVariation GWASCAT A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases. 29785011

2018
dbSNP: rs3001426
rs3001426
STAT6
0.700 GeneticVariation GWASCAT Detection and interpretation of shared genetic influences on 42 human traits. 27182965

2016
dbSNP: rs324011
rs324011
STAT6
0.040 GeneticVariation BEFREE A case-control study for association of STAT6 polymorphisms rs4559 and rs324011 with asthma risk was performed. 30511616

2018
dbSNP: rs324011
rs324011
STAT6
0.040 GeneticVariation BEFREE Both overall and subgroup analyses indicated no effect of rs324011 on asthma risk. 24952213

2014
dbSNP: rs324011
rs324011
STAT6
0.040 GeneticVariation BEFREE By the contrast of alleles tests, no significant differences between asthma and healthy groups were detected for both variants (rs324011: X(2)=0.25, Pearson's P-value=0.617; rs324015: X(2)=0.068, Pearson's P=0.814).When testing for genotypes, rs324011 homozygous T/T genotype was significantly associated with asthma, when the Recessive model is considered (T/T vs. C/C+C/T) (adjusted, OR=2.49, 95% CI=1.18-5.25, Pearson's P=0.014(∗), Yates' P=0.022(∗)). 24912007

2014
dbSNP: rs324011
rs324011
STAT6
0.040 GeneticVariation BEFREE No association was detected between the STAT6 polymorphism rs324011 or the TBXA2R polymorphisms rs8113232 and rs3786989 and asthma susceptibility. 22017802

2012
dbSNP: rs324015
rs324015
STAT6
0.020 GeneticVariation BEFREE In conclusion, our meta-analyses suggest that short GT repeats of rs71802646 in STAT6 contribute to higher risk for asthma, while rs324015 may have a protective effect on atopic asthma. 24952213

2014
dbSNP: rs324015
rs324015
STAT6
0.020 GeneticVariation BEFREE Rs324011 homozygous T/T genotype was significantly associated with asthma risk whereas rs324015 genotypes were not in the Saudi population. 24912007

2014
dbSNP: rs4559
rs4559
NAB2 ; STAT6
0.010 GeneticVariation BEFREE A case-control study for association of STAT6 polymorphisms rs4559 and rs324011 with asthma risk was performed. 30511616

2018
dbSNP: rs71802646
rs71802646
STAT6
0.010 GeneticVariation BEFREE In conclusion, our meta-analyses suggest that short GT repeats of rs71802646 in STAT6 contribute to higher risk for asthma, while rs324015 may have a protective effect on atopic asthma. 24952213

2014
dbSNP: rs1361210402
rs1361210402
STAT6
0.010 GeneticVariation BEFREE In addition, the significant gene-gene interactions among IL-4 -C33T, IL-13 R130Q, IL-4Ralpha I75V, IL-4Ralpha Q576R, STAT6 C2892T, and CD14 -C159T may increase an individual's susceptibility to asthma and contribute to the pathogenesis of asthma. 20394509

2010
dbSNP: rs759947306
rs759947306
STAT6
0.010 GeneticVariation BEFREE By haplotype analysis, the C-G and T-A haplotypes consisting of IL-13 C19</span>23T</span> and IL-13 R130Q and the G-A and A-A haplotypes consisting of IL-4Ralpha I75V and IL-4Ralpha Q576R were significantly associated with asthma (p < .05). 20394509

2010