|
rs1042713
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These findings show that the risk of development of asthma or response to treatment can be, respectively, deciphered by the detection of both rs1042713 and rs1042714 variants in <i>ADRB2</i> gene.
|
30468638 |
2019 |
|
rs1042713
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The present meta-analysis demonstrated that C79G and C491T polymorphism may be a defensive factor for asthma, while A46G polymorphism may be a risk factor for asthma among the Caucasian population.
|
31115019 |
2019 |
|
rs1042713
|
|
|
0.100 |
GeneticVariation |
BEFREE |
For the rs1042713 polymorphism, no significant association with asthma risk was found in the overall population.
|
31699066 |
2019 |
|
rs1042714
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Expression of the C7</span>9G polymorphism of the ADRB2 gene was significantly associated with risk of pediatric asthma associated with the C or G allele with comparison of the co-dominant model (GG vs. CC: OR, 0.69; 95% CI, 0.55-0.88) and the recessive model (GG vs. CC+CG: OR, 0.65; 95% CI, 0.53-0.81).
|
31142730 |
2019 |
|
rs1042714
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In the age stratification analysis, C79G polymorphism owned a reduced effect on asth</span>ma risk for children (GG vs. CC: OR=0.69, p=0.002; GG vs. CC+CG: OR=0.65, p<0.001).
|
31115019 |
2019 |
|
rs1042714
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These findings show that the risk of development of asthma or response to treatment can be, respectively, deciphered by the detection of both rs1042713 and rs1042714 variants in <i>ADRB2</i> gene.
|
30468638 |
2019 |
|
rs1042714
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The meta-analysis suggests that the ADRB2 rs1042714 polymorphism has a protective association with asthma in the overall population and the pediatric subgroup.
|
31699066 |
2019 |
|
rs1042713
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To assess the clinical value of ADRB2 rs1042713 in children with asthma using LABA, a randomized clinical trial with well-defined outcomes is needed.
|
29992699 |
2018 |
|
rs1042713
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The findings suggest that the Arg16Gly and Gln27Glu polymorphisms in the β2-AR gene are associated with asthma severity and response to therapy and might be used in personalized treatment for these patients in the future.
|
30178312 |
2018 |
|
rs1042714
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The findings suggest that the Arg16Gly and Gln27Glu polymorphisms in the β2-AR gene are associated with asthma severity and response to therapy and might be used in personalized treatment for these patients in the future.
|
30178312 |
2018 |
|
rs1042713
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this study we determined the relationship between the ADRB2 Arg16Gly polymorphism and GSTP1 polymorphisms, involved in bronchodilator response and oxidative stress, respectively, with susceptibility to asthma.
|
27385593 |
2016 |
|
rs1042713
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The primary objective was to determine the association between beta-2 adrenergic receptor (ADRB2) gene polymorphism (rs1042713, c.46A>G, p.Arg16Gly) and the response to inhaled salbutamol in North Indian children aged 5 to 15 years, with mild to moderate exacerbation of asthma.
|
27029682 |
2016 |
|
rs1042713
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A four-way gene-gene interaction model consisting of IL13 rs20541, IL4 rs2243250, ADRB2 rs1042713, and FCER1B rs569108 was chosen as the optimal one for determining asthma susceptibility (testing balanced accuracy = 0.6089, cross-validation consistency = 10/10, P = 6.98E-05).
|
26613553 |
2016 |
|
rs1042713
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Prospective genotype-stratified clinical trials are now required to explore the potential role of rs104</span>2713 genotyping for personalized asthma therapy in children.
|
26774659 |
2016 |
|
rs1042713
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Analysis of ADRB2 (Arg16Gly) Gene Variant with Susceptibility, Pharmacogenetic Response and Disease Severity in South Indian Asthmatics.
|
26071206 |
2015 |
|
rs1042713
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To compare the effectiveness and safety of tiotropium vs LABAs, when used with inhaled corticosteroids (ICS) in black adults with asthma and to determine whether allelic variation at the Arg16Gly locus of the β2-adrenergic receptor (ADRB2) geneis associated with treatment response.
|
26505596 |
2015 |
|
rs1042713
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Arg16Gly and Gln27Glu polymorphisms do not determine the occurrence of asthma individually, but the GG-CG haplotype is associated with an increased risk of asthma.
|
25985706 |
2015 |
|
rs1042714
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Arg16Gly and Gln27Glu polymorphisms do not determine the occurrence of asthma individually, but the GG-CG haplotype is associated with an increased risk of asthma.
|
25985706 |
2015 |
|
rs1042713
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Chinese Han children with asthma</span> had significantly higher frequencies of MS4A2 C-109T T/T (OR=1.961, P=0.001) and ADRB2 R16G A/A (OR=2.575, P=0.000) than the control group.
|
24838642 |
2014 |
|
rs1042713
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis implied that the β2-adrenoceptor Arg/Gly16 polymorphism was likely to contribute to asthma risk in Asian population.
|
24992184 |
2014 |
|
rs1042714
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In Serbian adults, carriers of the 27Gln allele and 27Gln/Gln genotype were at higher risk of asthma [odds ratio (OR) 2.5, 95% confidence interval (CI) 1.6-3.8, and OR 3.00, 95% CI 1.7-5.3, respectively], while the presence of the 27Glu allele and 27Gln/Glu genotype were found to be protective of asthma (OR 0.4, 95% CI 0.3-0.6, and OR 0.3, 95% CI 0.1-0.7, respectively).
|
25074500 |
2014 |
|
rs1042714
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Gln/Glu27 polymorphism might be a contributor to asthma susceptibility for adults.
|
24992184 |
2014 |
|
rs1042713
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These results suggest Gly16Arg genotyping in Caucasian asthma patients may have a role in the clinical management of asthma by influencing the decision of which add-on therapy to prescribe; however, larger studies are required to provide definitive conclusions regarding the clinical utility of this approach.
|
23205695 |
2013 |
|
rs1042713
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Adrenoceptor beta 2, surface gene (ADRB2) Gly16Arg genotypes have been associated with β2-agonist bronchodilator response, asthma exacerbation rate, response to methacholine, and lung function decline but not specifically in African Americans.
|
23384627 |
2013 |
|
rs1042713
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A significant outcome was that all variant alleles at the SNP loci were part of the haplotype conferring resistance to malaria disease and asthma, except rs1042713 and rs1042718 which showed very high frequency in asthma.
|
24012958 |
2013 |