|
rs61816761
|
|
A |
0.780 |
GeneticVariation |
GWASCAT |
Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies.
|
31036433 |
2019 |
|
rs61816761
|
|
A |
0.780 |
GeneticVariation |
GWASCAT |
Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis.
|
31619474 |
2019 |
|
rs61816761
|
|
A |
0.780 |
GeneticVariation |
GWASCAT |
Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study.
|
30552067 |
2019 |
|
rs61816761
|
|
A |
0.780 |
GeneticVariation |
GWASCAT |
Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct.
|
30929738 |
2019 |
|
rs61816761
|
|
|
0.780 |
GeneticVariation |
BEFREE |
We genotyped single nucleotide polymorphisms (SNPs): -105/rs28665122 in SELS or SEPS1 (selenoprotein), three single nucleotide polymorphisms in IL18 (-105/rs360717, +183/rs5744292 and +1467/rs574456) and R501X/rs61816761 in FLG, the major locus associated with atopic dermatitis and predisposing to asthma, in a minimum of 6743 T1D cases and 7864 controls.
|
22069270 |
2011 |
|
rs61816761
|
|
|
0.780 |
GeneticVariation |
BEFREE |
In the Polish patients with AD, the prevalence of FLG mutations was higher in patients with AD than in the controls and 2282del4 FLG mutation was more frequent than R501X, and it was associated with a 6-fold higher risk for AD development (P < 0.001; OR: 5.76), moderate or severe disease course, early onset of asthma and palmar hyperlinearity.
|
21426411 |
2011 |
|
rs61816761
|
|
|
0.780 |
GeneticVariation |
BEFREE |
We found a highly significant association of the FLG null variants R501X- and 2282del4 with AD (combined genotype p < 0.0001) and asthma (combined genotype p < 0.0001).
|
19538357 |
2009 |
|
rs61816761
|
|
|
0.780 |
GeneticVariation |
BEFREE |
FLG mutations R501X and 2282del4 were assayed in 1135 individuals ranging from 3 to 22 years old with asthma from Tayside and Dumfries, Scotland.
|
18307574 |
2008 |
|
rs61816761
|
|
|
0.780 |
GeneticVariation |
BEFREE |
Association analysis of the 2 common FLG-null mutations R501X and 2282del4 and 3 recently identified rare FLG variants (R2447X, S3247X, 3702delG) was performed on our cross-sectional population of German children (n = 3099) recruited as part of the International Study of Asthma and Allergies in Childhood II in Munich (n = 1159) and Dresden (n = 1940).
|
18396323 |
2008 |
|
rs61816761
|
|
|
0.780 |
GeneticVariation |
BEFREE |
We genotyped 2 loss-of-function FLG mutations (R501X and 2282del4) in white children (age 5-12 years) with mild to moderate asthma in the Childhood Asthma Management Program.
|
18073125 |
2007 |
|
rs61816761
|
|
|
0.780 |
GeneticVariation |
BEFREE |
Mutations in FLG/(R501X and 2282del4) are reported to be strongly associated with AD and to influence asthma accompanying AD.
|
17301831 |
2007 |
|
rs61816761
|
|
|
0.780 |
GeneticVariation |
BEFREE |
FLG mutations R501X and 2282del4 were assayed in 874 subjects 3 to 22 years old with asthma from Tayside.
|
17531295 |
2007 |
|
rs12123821
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis.
|
31619474 |
2019 |
|
rs12123821
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct.
|
30929738 |
2019 |
|
rs61816766
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases.
|
29785011 |
2018 |
|
rs71626704
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A total of seventy-three SNVs and 4 LOF mutations were successfully genotyped. rs71626704 and rs76413899 were significantly associated with a history of asthma and cheilitis (P = 0.002 and P = 0.033, respectively), however, the associations were not found statistically significant after adjustment by multiple comparisons.
|
29281699 |
2017 |
|
rs76413899
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A total of seventy-three SNVs and 4 LOF mutations were successfully genotyped. rs71626704 and rs76413899 were significantly associated with a history of asthma and cheilitis (P = 0.002 and P = 0.033, respectively), however, the associations were not found statistically significant after adjustment by multiple comparisons.
|
29281699 |
2017 |
|
rs941934
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CRNN rs941934 (A allele) was associated with AD (OR 2.095, p = 0.008), a severe course of disease (p = 0.041), elevated IgE levels (p = 0.047), eosinophilia (p = 0.018), and concomitant asthma (p = 0.004).
|
28219068 |
2017 |
|
rs11584340
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To investigate the effects of filaggrin (FLG) P478S polymorphisms and environmental factors on the risk of asthma in a cohort of children with atopic dermatitis (AD).
|
25528737 |
2015 |
|
rs138726443
|
|
|
0.010 |
GeneticVariation |
BEFREE |
FLG mutations R501X, 2282del4 and R2447X were genotyped in the Prevention and Incidence of Asthma and Mite Allergy birth cohort (n = 934) to evaluate longitudinally, for up to 8 years, their association with eczema, sensitization, asthma, hay fever and their interaction with cat exposure.
|
19839980 |
2009 |
|
rs150597413
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association analysis of the 2 common FLG-null mutations R501X and 2282del4 and 3 recently identified rare FLG variants (R2447X, S3247X, 3702delG) was performed on our cross-sectional population of German children (n = 3099) recruited as part of the International Study of Asthma and Allergies in Childhood II in Munich (n = 1159) and Dresden (n = 1940).
|
18396323 |
2008 |