Moreover, we examined whether susceptibility loci identified in previous meta-analyses of GWAS are associated with asthma in Puerto Ricans.The only locus to achieve genome-wide significance was chromosome 17q21, as evidenced by our top single nucleotide polymorphism (SNP), rs907092 (OR 0.71, p=1.2×10<sup>-12</sup>) at <i>IKZF3</i> Similar to results in non-Puerto Ricans, SNPs in genes in the same linkage disequilibrium block as <i>IKZF3</i> (<i>e.g.