|
rs1695
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We suggest that GSTP1 Ile105Val polymorphisms are involved in susceptibility to developing astrocytomas and glioblastomas.
|
21128213 |
2010 |
|
rs662
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The frequencies of the PON1 genotypes and allelic variants of the polymorphisms PON1 L55M and PON1 Q192R did not differ significantly between patients with astrocytoma and meningioma and controls.
|
20723250 |
2010 |
|
rs854560
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The frequencies of the PON1 genotypes and allelic variants of the polymorphisms PON1 L55M and PON1 Q192R did not differ significantly between patients with astrocytoma and meningioma and controls.
|
20723250 |
2010 |
|
rs121913499
|
|
T |
0.720 |
GeneticVariation |
CLINVAR |
Establishment of a novel monoclonal antibody SMab-1 specific for IDH1-R132S mutation.
|
21352804 |
2011 |
|
rs113488022
|
|
|
0.080 |
GeneticVariation |
BEFREE |
With regard to implications for therapy, our results support evaluation of BRAF(V600E)-specific inhibitors for treating BRAF(V600E) MA patients.
|
22038996 |
2011 |
|
rs121913377
|
|
|
0.080 |
GeneticVariation |
BEFREE |
With regard to implications for therapy, our results support evaluation of BRAF(V600E)-specific inhibitors for treating BRAF(V600E) MA patients.
|
22038996 |
2011 |
|
rs113488022
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The BRAF(V600E) inhibitor PLX4720 significantly increased survival of mice after intracranial transplant of genetically relevant murine or human astrocytoma cells.
|
22586120 |
2012 |
|
rs121913377
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The BRAF(V600E) inhibitor PLX4720 significantly increased survival of mice after intracranial transplant of genetically relevant murine or human astrocytoma cells.
|
22586120 |
2012 |
|
rs58064122
|
|
|
0.010 |
GeneticVariation |
BEFREE |
On the basis of the protective role shown by both these small heat shock proteins (sHSPs), and on the already well established neuroprotective effects of curcumin in several diseases, we have investigated the effects of this compound in an in vitro model of Alexander disease, consisting in U251-MG astrocytoma cells transiently transfected with a construct encoding for GFAP carrying the p.R239C mutation in frame with the reporter green fluorescent protein (GFP).
|
22705585 |
2012 |
|
rs861539
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We suggest that XRCC3 Thr241Met polymorphism is involved in susceptibility for developing astrocytomas and glioblastomas.
|
22370935 |
2012 |
|
rs121913500
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We investigated the expression of Sox11 in 132 diffuse astrocytomas in relation to the regulator cell marker nestin, c-Met and IDH1-R132H, which have shown to be differentially expressed among the molecular subgroups of malignant gliomas, as well as to an inducer of astrocytic differentiation, that is, signal transducer and activator of transcription (p-STAT-3), clinicopathological features and survival.
|
23619925 |
2013 |
|
rs1057519903
|
|
|
0.720 |
GeneticVariation |
BEFREE |
Because H3F3A K27M mutations occur exclusively in pediatric diffuse high-grade astrocytomas, analysis of codon 27 mutational status could be useful in the differential diagnosis of these neoplasms.
|
23429371 |
2013 |
|
rs2297440
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In the recessive model, we found two tSNPs (rs2297440 and rs6010620) associated with increased astrocytoma risk.
|
23812731 |
2013 |
|
rs137852972
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we show that expression of seipin N-glycosylation mutant N88S led to decreased triglyceride (TG) content in astrocytoma and motor neuron cell lines.
|
23250914 |
2013 |
|
rs2853676
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the additive model, all three tSNPs (rs2297440, rs2853676, and rs6010620) were associated with increased astrocytoma risk.
|
23812731 |
2013 |
|
rs6010620
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the additive model, all three tSNPs (rs2297440, rs2853676, and rs6010620) were associated with increased astrocytoma risk.
|
23812731 |
2013 |
|
rs121913500
|
|
T |
0.800 |
GeneticVariation |
CLINVAR |
Prospective enterprise-level molecular genotyping of a cohort of cancer patients.
|
25157968 |
2014 |
|
rs121913500
|
|
|
0.800 |
GeneticVariation |
BEFREE |
To study the putative expression patterns and clinical significance of Hsp27, we assessed the associations between Hsp27, R132H mutation of Isocitrate dehydrogenase1 (IDH1-R132H), Hypoxia-inducible factor subunit alpha (HIF-1 alpha), Carbonic anhydrase IX (CA IX), and patient prognosis in astrocytic gliomas.
|
24599602 |
2014 |
|
rs121913500
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Fractional anisotropy and ADC from DTI can noninvasively detect IDH1 R132H mutation in astrogliomas.
|
24557705 |
2014 |
|
rs121913500
|
|
|
0.800 |
GeneticVariation |
BEFREE |
As the presence of the p.R132H mutation in the IDH1 gene seems to be a more powerful prognostic marker than O(6)-methylguanine-DNA methyltransferase promoter status, we evaluated the presence of IDH1 mutation in Polish patients with astrocytoma, glioblastoma, oligoastrocytoma, ganglioglioma, oligodendroglioma, and ependymoma.
|
23934769 |
2014 |
|
rs1057519903
|
|
|
0.720 |
GeneticVariation |
BEFREE |
Additionally, H3F3A K27M was not detected in the 2 diffuse astrocytomas.
|
24285547 |
2014 |
|
rs121913499
|
|
A |
0.720 |
GeneticVariation |
CLINVAR |
Prospective enterprise-level molecular genotyping of a cohort of cancer patients.
|
25157968 |
2014 |
|
rs121913499
|
|
T |
0.720 |
GeneticVariation |
CLINVAR |
Prospective enterprise-level molecular genotyping of a cohort of cancer patients.
|
25157968 |
2014 |
|
rs113488022
|
|
|
0.080 |
GeneticVariation |
BEFREE |
BRAF V600E mutation was observed both in epithelioid tumor cells and in diffusely infiltrating less atypical astrocytoma cells.
|
24354918 |
2014 |
|
rs121913377
|
|
|
0.080 |
GeneticVariation |
BEFREE |
BRAF V600E mutation was observed both in epithelioid tumor cells and in diffusely infiltrating less atypical astrocytoma cells.
|
24354918 |
2014 |