Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs121913499
rs121913499
IDH1
0.720 GeneticVariation BEFREE Without exception, all were R132C (CGT-->TGT), which in sporadic astrocytomas accounts for <5% of IDH1 mutations. 19340432

2009
dbSNP: rs121913499
rs121913499
IDH1
A 0.720 GeneticVariation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968

2014
dbSNP: rs121913499
rs121913499
IDH1
T 0.720 GeneticVariation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968

2014
dbSNP: rs121913499
rs121913499
IDH1
0.720 GeneticVariation BEFREE IDH1 mutations of the R132C type are strongly associated with astrocytoma, while IDH2 mutations predominantly occur in oligodendroglial tumors. 19554337

2009
dbSNP: rs1040177874
rs1040177874
IDH1
0.010 GeneticVariation BEFREE Identification of a novel inactivating mutation in Isocitrate Dehydrogenase 1 (IDH1-R314C) in a high grade astrocytoma. 27460417

2016
dbSNP: rs118101777
rs118101777
IDH2
0.030 GeneticVariation BEFREE Of these, we recommend, OA,NOS and IDH1(R132H)-non-mt ODG,NOS to be our priority for performing 1p/19q co-deletion studies in comparison to IDH-mt ODG,NOS, and it would not be mandatory for astrocytoma. 28801347

2018
dbSNP: rs118101777
rs118101777
IDH2
0.030 GeneticVariation BEFREE No IDH1-R132H mutation was detected in 2 of 2 (0%) astrocytomas by immunohistochemistry. 26990854

2016
dbSNP: rs118101777
rs118101777
IDH2
0.030 GeneticVariation BEFREE ATRX and IDH1-R132H immunohistochemistry with subsequent copy number analysis and IDH sequencing as a basis for an "integrated" diagnostic approach for adult astrocytoma, oligodendroglioma and glioblastoma. 25427834

2015
dbSNP: rs1801275
rs1801275
IL4R
0.010 GeneticVariation BEFREE Univariate analysis showed that IL4R rs1801275 was significantly associated with overall survival of glioma and astrocytoma</span> patients (P < 0.05). 27495027

2016
dbSNP: rs1870377
rs1870377
KDR
0.010 GeneticVariation BEFREE However, individuals with mutant allele A and genotype TA + AA of rs1870377 showed a protective effect against astrocytomas. 26081139

2016
dbSNP: rs2071559
rs2071559
KDR
0.010 GeneticVariation BEFREE Meanwhile, stratified analysis demonstrated that mutation of rs2071559 and rs2305948 could elevate the risk of astrocytomas more significantly in the subgroup of smokers than the nonsmokers. 26081139

2016
dbSNP: rs2305948
rs2305948
KDR
0.010 GeneticVariation BEFREE Meanwhile, stratified analysis demonstrated that mutation of rs2071559 and rs2305948 could elevate the risk of astrocytomas more significantly in the subgroup of smokers than the nonsmokers. 26081139

2016
dbSNP: rs861539
rs861539
KLC1 ; XRCC3
0.010 GeneticVariation BEFREE We suggest that XRCC3 Thr241Met polymorphism is involved in susceptibility for developing astrocytomas and glioblastomas. 22370935

2012
dbSNP: rs2378456
rs2378456
LPP
0.010 GeneticVariation BEFREE In recessive model, the patients with LPP rs2378456 CC genotype increased the risk of astrocytoma (OR = 1.43, 95% CI 1.01-2.02, p = 0.042). 31440994

2019
dbSNP: rs7115578
rs7115578
MAML2
0.010 GeneticVariation BEFREE Additionally, rs7115578 AG genotype represented a poorer prognosis of glioma (HR = 1.24, P=0.033) and astrocytoma (log-rank P=0.037, HR = 1.31, P=0.036). 31652449

2019
dbSNP: rs2431689
rs2431689
MIR3142HG
0.010 GeneticVariation BEFREE Rs17057846, rs1582417, and rs2431689 polymorphisms were associated with prognosis of astrocytoma, and rs1582417, rs17057846, and rs58747524 variants were associated with the survival rate in patients with low-grade glioma (I to II). 31513017

2020
dbSNP: rs1057519369
rs1057519369
NF1
TG 0.700 CausalMutation CLINVAR

dbSNP: rs3745601
rs3745601
P2RY11 ; PPAN-P2RY11
0.010 GeneticVariation BEFREE We investigated receptor functionality of the P2Y11 A87T mutant using HEK293 and 1321N1 astrocytoma cells. 24524250

2014
dbSNP: rs281865545
rs281865545
PECAM1
0.010 GeneticVariation BEFREE ICAM-1 (Lys469Glu) and PECAM-1 (Leu125Val) polymorphisms in diffuse astrocytomas. 19306055

2009
dbSNP: rs662
rs662
PON1
0.010 GeneticVariation BEFREE The frequencies of the PON1 genotypes and allelic variants of the polymorphisms PON1 L55M and PON1 Q192R did not differ significantly between patients with astrocytoma and meningioma and controls. 20723250

2010
dbSNP: rs854560
rs854560
PON1
0.010 GeneticVariation BEFREE The frequencies of the PON1 genotypes and allelic variants of the polymorphisms PON1 L55M and PON1 Q192R did not differ significantly between patients with astrocytoma and meningioma and controls. 20723250

2010
dbSNP: rs121918464
rs121918464
PTPN11
A 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016
dbSNP: rs121918465
rs121918465
PTPN11
G 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016
dbSNP: rs121918465
rs121918465
PTPN11
C 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016
dbSNP: rs751857027
rs751857027
QTRT1
0.010 GeneticVariation BEFREE Without exception, all were R132C (CGT-->TGT), which in sporadic astrocytomas accounts for <5% of IDH1 mutations. 19340432

2009