|
rs2106261
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The GRS was calculated using 5 SNPs (rs1448818, rs2200733, rs6843082, rs6838973 at chromosome 4q25 [<i>PITX2</i>] and rs2106261 at chromosome 16q22 [<i>ZFHX3</i>]), which showed modest associations with AF recurrence.
|
30808078 |
2019 |
|
rs2106261
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Rs13376333 on chromosome 1q21 (in KCNN3), rs7193343 and rs2106261 on chromosome 16q22 (in ZFHX3) were not associated with AF recurrence in our meta-analysis.
|
31169720 |
2019 |
|
rs2106261
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The ZFHX3 SNP rs2106261 minor allele is associated with lower AF recurrence rate after pulmonary vein isolation.
|
30180182 |
2018 |
|
rs2106261
|
|
T |
0.900 |
GeneticVariation |
GWASCAT |
Identification of six new genetic loci associated with atrial fibrillation in the Japanese population.
|
28416822 |
2017 |
|
rs2106261
|
|
T |
0.900 |
GeneticVariation |
GWASCAT |
Korean atrial fibrillation network genome-wide association study for early-onset atrial fibrillation identifies novel susceptibility loci.
|
28460022 |
2017 |
|
rs2106261
|
|
T |
0.900 |
GeneticVariation |
GWASCAT |
Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.
|
28416818 |
2017 |
|
rs2106261
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We showed that the ZFHX3 polymorphism, rs2106261 (A allele), was a risk marker for AF and AF-related phenotypes.
|
28007413 |
2017 |
|
rs2106261
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Among GWAS loci for AF, only three were replicated in the Chinese Han population, including SNP rs2106261 (G/A substitution) in ZFHX3, rs2200733 (C/T substitution) near PITX2c, and rs3807989 (A/G substitution) in CAV1.
|
26267381 |
2015 |
|
rs2106261
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The SNPs at the PITX2 and ZFHX3 loci, but not the KCNN3 locus, were significantly associated with AF (PITX2/rs6843082_G: odds ratio 3.41, 95% CI 2.55 to 4.55, P=1.32×10(-16); PITX2/rs2200733_T: odds ratio 2.05, 95% CI 1.66 to 2.53, P=2.20×10(-11); ZFHX3/rs2106261_A: odds ratio 2.33, 95% CI 1.87 to 2.91, P=3.75×10(-14); KCNN3/rs13376333_T: odds ratio 1.74, 95% CI 0.93 to 3.25, P=0.085).
|
26272656 |
2015 |
|
rs2106261
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In summary, our study investigated the role of genetic variants of ZFHX3 in AF and two SNPs (rs2106261, rs6499600) showed significant associations while rs16971436 conferred a borderline significant association with AF risk in Chinese Han populations.
|
24983873 |
2014 |
|
rs2106261
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Genetic polymorphisms in the chromosomal regions 4q25 (rs2200733) and 16q22 (rs2106261) associated with AF in genome-wide association studies were genotyped.
|
23132824 |
2013 |
|
rs2106261
|
|
T |
0.900 |
GeneticVariation |
GWASDB |
Meta-analysis identifies six new susceptibility loci for atrial fibrillation.
|
22544366 |
2012 |
|
rs2106261
|
|
T |
0.900 |
GeneticVariation |
GWASCAT |
Meta-analysis identifies six new susceptibility loci for atrial fibrillation.
|
22544366 |
2012 |
|
rs2106261
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our results indicate that rs2106261 in ZFHX3 confers a significant risk of AF in a Chinese Han population.
|
21107608 |
2011 |
|
rs2106261
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 x 10(-7)).
|
19597492 |
2009 |
|
rs2106261
|
|
T |
0.900 |
GeneticVariation |
GWASDB |
Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 x 10(-7)).
|
19597492 |
2009 |
|
rs2106261
|
|
T |
0.900 |
GeneticVariation |
GWASCAT |
Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 x 10(-7)).
|
19597492 |
2009 |
|
rs7193343
|
|
|
0.870 |
GeneticVariation |
BEFREE |
Rs13376333 on chromosome 1q21 (in KCNN3), rs7193343 and rs2106261 on chromosome 16q22 (in ZFHX3) were not associated with AF recurrence in our meta-analysis.
|
31169720 |
2019 |
|
rs7193343
|
|
|
0.870 |
GeneticVariation |
BEFREE |
Common single nucleotide polymorphisms (SNPs) at chromosomes 4q25 (rs2200733, rs10033464 near PITX2), 1q21 (rs13376333 in KCNN3), and 16q22 (rs7193343 in ZFHX3) have consistently been associated with the risk of atrial fibrillation (AF).
|
25684755 |
2015 |
|
rs7193343
|
|
|
0.870 |
GeneticVariation |
BEFREE |
In Caucasian population, genetic variant rs7193343 SNP is associated with risk of AF in Caucasian population.
|
26112950 |
2015 |
|
rs7193343
|
|
|
0.870 |
GeneticVariation |
BEFREE |
Variants rs2200733 and rs7193343 are associated with a higher risk of atrial fibrillation.
|
25262128 |
2014 |
|
rs7193343
|
|
|
0.870 |
GeneticVariation |
BEFREE |
All the polymorphisms tested (except rs17570669) correlated significantly with AF in univariate analysis (p values between 0.039 for rs7193343 and 2.7e-27 for rs2200733), with the odds ratio (OR) 0.572 and 0.617 for rs3853445 and rs6838973, respectively (protective role) and OR 1.268 to 3.52 for the other polymorphisms.
|
21760908 |
2011 |
|
rs7193343
|
|
|
0.870 |
GeneticVariation |
BEFREE |
Recent genome-wide association studies (GWAS) identified two single nucleotide polymorphisms (SNPs), rs2106261 and rs7193343 in ZFHX3 (zinc finger homeobox 3 gene) and rs13376333 in KCNN3 (encoding a potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3) that showed significant association with AF in multiple populations of European ancestry.
|
21107608 |
2011 |
|
rs7193343
|
|
|
0.870 |
GeneticVariation |
BEFREE |
A variant in the ZFHX3 gene on chromosome 16q22, rs7193343-T, associated significantly with AF (odds ratio OR = 1.21, P = 1.4 x 10(-10)).
|
19597491 |
2009 |
|
rs7193343
|
|
T |
0.870 |
GeneticVariation |
GWASDB |
A variant in the ZFHX3 gene on chromosome 16q22, rs7193343-T, associated significantly with AF (odds ratio OR = 1.21, P = 1.4 x 10(-10)).
|
19597491 |
2009 |