Gene: SCN5A ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs7374540
rs7374540
SCN5A
A 0.700 GeneticVariation GWASCAT Biobank-driven genomic discovery yields new insight into atrial fibrillation biology. 30061737

2018
dbSNP: rs7374540
rs7374540
SCN5A
A 0.700 GeneticVariation GWASCAT Multi-ethnic genome-wide association study for atrial fibrillation. 29892015

2018
dbSNP: rs199473260
rs199473260
SCN5A
C 0.700 GeneticVariation CLINVAR

dbSNP: rs1805124
rs1805124
SCN5A
0.030 GeneticVariation BEFREE The composition of genotypes and alleles of 1673 A>G and 3666+69 G>C in the AF group was significantly different from that of the control group (p<0.05). 31486511

2019
dbSNP: rs1805124
rs1805124
SCN5A
0.030 GeneticVariation BEFREE In conclusion, this study provided evidence for the role of the H558R polymorphism of the SCN5A gene in increasing the susceptibility to AF. 22117993

2011
dbSNP: rs1805124
rs1805124
SCN5A
0.030 GeneticVariation BEFREE Genotypes at the AF-associated loci in KCNE1 (S38G) and SCN5A (H558R) were determined by direct DNA sequencing. 19305639

2009
dbSNP: rs41261344
rs41261344
SCN5A
0.010 GeneticVariation BEFREE Our data suggest that R1193Q polymorphism is likely to be a genetic marker for the major adverse effects associated with propafenone PIP approach for AF </span>patients' management. 30984031

2019
dbSNP: rs756805318
rs756805318
SCN5A
0.010 GeneticVariation BEFREE Significant association was identified in the two independent populations and in the combined population (p = 4.16 × 10<sup>-4</sup> , odds ratio [OR] = 3.14) between p.Gly8Ser and common AF as well as lone AF (p = 0.018, OR = 2.85). 30821358

2019
dbSNP: rs199473112
rs199473112
SCN5A
0.010 GeneticVariation BEFREE Two variants have been previously reported; one is associated with atrial fibrillation (SCN5A_p.H445D), and the other is predicted to be benign (ANK2_p.T2059M). 28086167

2017
dbSNP: rs11708996
rs11708996
SCN5A
0.010 GeneticVariation BEFREE In this meta-analysis, both rs10428132 at SCN10A (OR=0.73, P=5.7 × 10(-6)) and rs11708996 at SCN5A (OR=0.80, P=0.02) showed a statistically significant decreased risk of AF. 24667784

2014
dbSNP: rs7626962
rs7626962
SCN5A
0.010 GeneticVariation BEFREE We examined the association of rs7626962 (S1103Y) or rs7629265, a variant in high linkage disequilibrium with S1103Y (r(2) = 0.87 - 1), with sudden cardiac death (SCD) and atrial fibrillation (AF) among African Americans. 25065297

2014
dbSNP: rs7629265
rs7629265
SCN5A
0.010 GeneticVariation BEFREE The common SCN5A variant, rs7629265, is associated with increased AF risk and shorter PR interval among African Americans. 25065297

2014
dbSNP: rs778337208
rs778337208
SCN5A
0.010 GeneticVariation BEFREE We identified 2 nonsynonymous variants in SCN1B (resulting in R85H, D153N) and 2 in SCN2B (R28Q, R28W) in patients with AF. 19808477

2009
dbSNP: rs199473324
rs199473324
SCN5A
0.010 GeneticVariation BEFREE A novel SCN5A gain-of-function mutation M1875T associated with familial atrial fibrillation. 18929244

2008