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rs751945904
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Human neurons carrying the syndromic autism mutation NLGN4-R704C also formed more excitatory synapses but with increased functional synaptic transmission due to a postsynaptic mechanism, while genetic loss of NLGN4 did not significantly affect synapses in the human neurons analyzed.
|
31257103 |
2019 |
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rs751945904
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Here, we analysed the effect of a single amino-acid substitution (R704C) that targets a conserved arginine residue in the cytoplasmic sequence of all neuroligins, and that was associated with autism in neuroligin-4.
|
21642956 |
2011 |
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rs1882260
|
|
|
0.010 |
GeneticVariation |
BEFREE |
According to both the European and the Italian control groups, a 6-marker haplotype on <i>NLGN4X</i> (rs6638575(G), rs3810688(T), rs3810687(G), rs3810686(C), rs5916269(G), rs1882260(T)) was associated with autism (odd ratio = 3.58, <i>p</i>-value = 2.58 × 10<sup>-6</sup> for the European controls; odds ratio = 2.42, <i>p</i>-value = 6.33 × 10<sup>-3</sup> for the Italian controls).
|
27782075 |
2016 |
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rs3810686
|
|
|
0.010 |
GeneticVariation |
BEFREE |
According to both the European and the Italian control groups, a 6-marker haplotype on <i>NLGN4X</i> (rs6638575(G), rs3810688(T), rs3810687(G), rs3810686(C), rs5916269(G), rs1882260(T)) was associated with autism (odd ratio = 3.58, <i>p</i>-value = 2.58 × 10<sup>-6</sup> for the European controls; odds ratio = 2.42, <i>p</i>-value = 6.33 × 10<sup>-3</sup> for the Italian controls).
|
27782075 |
2016 |
|
rs3810687
|
|
|
0.010 |
GeneticVariation |
BEFREE |
According to both the European and the Italian control groups, a 6-marker haplotype on <i>NLGN4X</i> (rs6638575(G), rs3810688(T), rs3810687(G), rs3810686(C), rs5916269(G), rs1882260(T)) was associated with autism (odd ratio = 3.58, <i>p</i>-value = 2.58 × 10<sup>-6</sup> for the European controls; odds ratio = 2.42, <i>p</i>-value = 6.33 × 10<sup>-3</sup> for the Italian controls).
|
27782075 |
2016 |
|
rs3810688
|
|
|
0.010 |
GeneticVariation |
BEFREE |
According to both the European and the Italian control groups, a 6-marker haplotype on <i>NLGN4X</i> (rs6638575(G), rs3810688(T), rs3810687(G), rs3810686(C), rs5916269(G), rs1882260(T)) was associated with autism (odd ratio = 3.58, <i>p</i>-value = 2.58 × 10<sup>-6</sup> for the European controls; odds ratio = 2.42, <i>p</i>-value = 6.33 × 10<sup>-3</sup> for the Italian controls).
|
27782075 |
2016 |
|
rs5916269
|
|
|
0.010 |
GeneticVariation |
BEFREE |
According to both the European and the Italian control groups, a 6-marker haplotype on <i>NLGN4X</i> (rs6638575(G), rs3810688(T), rs3810687(G), rs3810686(C), rs5916269(G), rs1882260(T)) was associated with autism (odd ratio = 3.58, <i>p</i>-value = 2.58 × 10<sup>-6</sup> for the European controls; odds ratio = 2.42, <i>p</i>-value = 6.33 × 10<sup>-3</sup> for the Italian controls).
|
27782075 |
2016 |
|
rs6638575
|
|
|
0.010 |
GeneticVariation |
BEFREE |
According to both the European and the Italian control groups, a 6-marker haplotype on <i>NLGN4X</i> (rs6638575(G), rs3810688(T), rs3810687(G), rs3810686(C), rs5916269(G), rs1882260(T)) was associated with autism (odd ratio = 3.58, <i>p</i>-value = 2.58 × 10<sup>-6</sup> for the European controls; odds ratio = 2.42, <i>p</i>-value = 6.33 × 10<sup>-3</sup> for the Italian controls).
|
27782075 |
2016 |
|
rs3747333
|
|
|
0.010 |
GeneticVariation |
BEFREE |
By case-control analysis, we identified the common SNPs (rs3747333 and rs3747334) in the NLGN4X gene significantly associated with risk for autism [p = 5.09E-005; OR 4.685 (95% CI 2.073-10.592)].
|
24570023 |
2014 |
|
rs3747334
|
|
|
0.010 |
GeneticVariation |
BEFREE |
By case-control analysis, we identified the common SNPs (rs3747333 and rs3747334) in the NLGN4X gene significantly associated with risk for autism [p = 5.09E-005; OR 4.685 (95% CI 2.073-10.592)].
|
24570023 |
2014 |
|
rs144093574
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the preliminary study of specific exons of NLGN3 and NLGN4 genes, we identified the p.K378R substitution (c.1597 A > G) in exon 5 of the NLGN4 gene in a patient who was found to have mild autism and normal IQ at 3 years of age.
|
19645625 |
2009 |
|
rs2290488
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A family-based association study for rs2290488 in 101 trios did not reveal association of this polymorphism with autistic disorders on high functioning level.
|
18189281 |
2008 |