|
rs710521
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Fine-mapping of the GWAS signal region led to the identification of twenty SNPs that showed a stronger association with bladder cancer risk than rs710521.
|
29956121 |
2018 |
|
rs710521
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Performing a meta-analysis of 5,695 cases and 40,187 controls including all published studies on rs710521, a convincing association with bladder cancer risk was obtained (OR = 1.18; 95% Cl = 1.12-1.25; P < 0.0001).
|
21063684 |
2010 |
|
rs710521
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We genotyped rs9642880 G>T on 8q24 and rs710521</span> A>G on 3q28 in a two-stage case-control study of bladder cancer to evaluate the association and further examined the expression of MYC.
|
19369583 |
2009 |
|
rs710521
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Genome-wide association studies have confirmed association of TP63C/T rs710521, TERTC/T rs2736098, and SLC14A1C/T rs17674580 gene variants with susceptibility to bladder cancer (BC) in European and White population.
|
25218484 |
2014 |
|
rs833052
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Our meta-analysis suggested that rs3025039 (C > T), rs833052 (C > A) and rs25648 (C > T) polymorphisms of VEGF gene increased susceptibility to BCa risk.
|
30849545 |
2019 |
|
rs833052
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We found that the A allele of rs699947 and the A allele of rs833052 within VEGF gene, interaction between rs2010963 and smoking, haplotype containing the rs2010963- C and rs833052- A alleles were all associated with increased bladder cancer risk.
|
28206971 |
2017 |
|
rs833052
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Three additional SNPs in the promoter region (rs833052, rs1109324, and rs1547651) were associated with increased risk for bladder cancer: odds ratio (95% confidence interval): 2.52 (1.06-5.97), 2.74 (1.26-5.98), and 3.02 (1.36-6.63), respectively; and a polymorphism in intron 2 (rs3024994) was associated with reduced risk: 0.65 (0.46-0.91).
|
17319747 |
2007 |
|
rs833052
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The VEGF gene rs3025039C/T and rs833052C/A variants may contribute to the risk of developing BCa, especially in Asian descendants.
|
30609111 |
2019 |
|
rs1014971
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In a combined analysis, we identified three new regions associated with bladder cancer on chromosomes 22q13.1, 19q12 and 2q37.1: rs1014971, (P = 8 × 10⁻¹²) maps to a non-genic region of chromosome 22q13.1, rs8102137 (P = 2 × 10⁻¹¹) on 19q12 maps to CCNE1 and rs11892031 (P = 1 × 10⁻⁷) maps to the UGT1A cluster on 2q37.1.
|
20972438 |
2010 |
|
rs1014971
|
|
|
0.020 |
GeneticVariation |
BEFREE |
SNP rs1014971 was associated with bladder cancer risk, increased APOBEC3B expression, and enrichment with APOBEC-signature mutations in bladder tumors.
|
27643540 |
2016 |
|
rs1495741
|
|
|
0.020 |
GeneticVariation |
BEFREE |
To quantify the association between rs1495741 and the risk of bladder cancer and to estimate the interaction effect of this genetic variant with smoking, we performed a systematic literature review and meta-analysis involving 14,815 cases and 58,282 controls from 29 studies.
|
27495060 |
2016 |
|
rs1495741
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Overall, seven of the 14 variants were significantly associated with bladder cancer risk (p = 9.763 × 10(-3) for rs9642880 at 8q24.21, p = 3.004 × 10(-3) for rs2294008 at 8q24.3, p = 0.012 for rs798766 at 4p16.3, p = 0.034 for rs1495741 at </span>8p22, p = 2.306 × 10(-4) for GSTM1, p = 8.507 × 10(-8) for rs17674580 at 18q12.3, p = 7.179 × 10(-4) for rs10936599 at 3q26.2) and the odds ratios (ORs) ranged from 1.13 to 1.65.
|
24740636 |
2014 |
|
rs8102137
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In a combined analysis, we identified three new regions associated with bladder cancer on chromosomes 22q13.1, 19q12 and 2q37.1: rs1014971, (P = 8 × 10⁻¹²) maps to a non-genic region of chromosome 22q13.1, rs8102137 (P = 2 × 10⁻¹¹) on 19q12 maps to CCNE1 and rs11892031 (P = 1 × 10⁻⁷) maps to the UGT1A cluster on 2q37.1.
|
20972438 |
2010 |
|
rs8102137
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We found that the original GWAS marker rs8102137 represents a group of 47 linked SNPs (with r(2) ≥ 0.7) associated with increased bladder cancer risk.
|
25320178 |
2014 |
|
rs10234749
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Lastly, XRCC2 homozygote variants for three promoter SNPs (rs10,234,749, rs6,464,268, rs3,218,373) and one non-synonymous SNP (rs3,218,536, R188H) were associated with reduced bladder cancer risk (ORs ranging from 0.36 to 0.50 compared with common homozygotes).
|
17557904 |
2007 |
|
rs1024611
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We tested association of three gene polymorphisms of CCL2I/D (rs3917887), CCL2A2518G (rs1024611) and CCR2V64I (rs1799864) with BC risk in North Indian population.
|
22733495 |
2012 |
|
rs10811474
|
|
|
0.010 |
GeneticVariation |
BEFREE |
ASSET analyses identified four SNPs significantly associated with multiple cancers: rs3731239 (CDKN2A intronic) with ESCC, GC and BC (P = 3.96 × 10(-) (4)); rs10811474 (3' of IFNW1) with RCC and BrC (P = 0.001); rs12683422 (LINGO2 intronic) with RCC and BC (P = 5.93 × 10(-) (4)) and rs10511729 (3' of ELAVL2) with LC and BrC (P = 8.63 × 10(-) (4)).
|
25239644 |
2014 |
|
rs1109324
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three additional SNPs in the promoter region (rs833052, rs1109324, and rs1547651) were associated with increased risk for bladder cancer: odds ratio (95% confidence interval): 2.52 (1.06-5.97), 2.74 (1.26-5.98), and 3.02 (1.36-6.63), respectively; and a polymorphism in intron 2 (rs3024994) was associated with reduced risk: 0.65 (0.46-0.91).
|
17319747 |
2007 |
|
rs1547651
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three additional SNPs in the promoter region (rs833052, rs1109324, and rs1547651) were associated with increased risk for bladder cancer: odds ratio (95% confidence interval): 2.52 (1.06-5.97), 2.74 (1.26-5.98), and 3.02 (1.36-6.63), respectively; and a polymorphism in intron 2 (rs3024994) was associated with reduced risk: 0.65 (0.46-0.91).
|
17319747 |
2007 |
|
rs2505568
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The AT heterozygote of rs2505568 may prevent the recurrence of bladder cancer</span>.
|
24363084 |
2014 |
|
rs2764736
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified that rs1063192 and rs2157719 in the CDKN2A/2B region were significantly associated with ESCC and rs2764736 (3' of TUSC1) was associated with BC (P ≤ 2.59 × 10(-6)).
|
25239644 |
2014 |
|
rs398652
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We then conducted a mediation analysis to examine whether the association between rs398652 and reduced bladder cancer risk is mediated by telomere length, finding that telomere length was a significant mediator of the relationship between rs398652 and bladder cancer (P = 0.013), explaining 14% of the effect.
|
21460395 |
2011 |
|
rs6464268
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Lastly, XRCC2 homozygote variants for three promoter SNPs (rs10,234,749, rs6,464,268, rs3,218,373) and one non-synonymous SNP (rs3,218,536, R188H) were associated with reduced bladder cancer risk (ORs ranging from 0.36 to 0.50 compared with common homozygotes).
|
17557904 |
2007 |
|
rs715021
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Recently, the first genome-wide association study of bladder cancer identified an association of genome-wide significance between single nucleotide polymorphism (SNP) rs715021 and urinary bladder cancer risk among European individuals.
|
19843673 |
2009 |
|
rs874945
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study showed that rs874945 in HOTAIR was associated with BCa risk in a Chinese population.
|
29673865 |
2018 |