|
rs121913343
|
|
|
0.710 |
GeneticVariation |
BEFREE |
The most frequent mutation in sporadic brain tumors is mutation R273C, which is relatively rare in grade 4 tumors compared with lower-grade tumors (p = 1.2 × 10(-5), OR 0.43, 95% CI 0.29-0.63).
|
24481542 |
2014 |
|
rs55819519
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Cytosolic isocitrate dehydrogenase 1 (IDH1) with an R132H mutation in brain tumors loses its enzymatic activity for catalyzing isocitrate to α-ketoglutarate (α-KG) and acquires new activity whereby it converts α-KG to 2-hydroxyglutarate.
|
24077277 |
2013 |
|
rs55819519
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A total of 343 brain tumors were studied for IDH1 and IDH2 mutations by direct sequencing and for protein expression by immunohistochemistry with mIDH1(R132H) antibody.
|
21643842 |
2011 |
|
rs1042522
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We suggest that TP53 Pro47Ser and Arg72Pro polymorphisms and DNA hypermethylation are involved in susceptibility for developing extra-axial brain tumors.
|
19224462 |
2009 |
|
rs1131691014
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We suggest that TP53 Pro47Ser and Arg72Pro polymorphisms and DNA hypermethylation are involved in susceptibility for developing extra-axial brain tumors.
|
19224462 |
2009 |
|
rs878854066
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We suggest that TP53 Pro47Ser and Arg72Pro polymorphisms and DNA hypermethylation are involved in susceptibility for developing extra-axial brain tumors.
|
19224462 |
2009 |
|
rs1042522
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Specifically, we found (i) that the genotype distributions of the P53 Arg72Pro between all brain tumors</span> and controls were statistically significant (P < 0.001) as well as their variant allele frequencies between cases and controls (P < 0.001); (ii) that there was a significant increase in the Arg/Pro heterozygous genotype among high-grade astrocytomas compared with non-astrocytomas (P = 0.002); and (iii) that there was a significant increase in the Arg/Pro heterozygous genotype among high-grade astrocytomas containing transdominant as well as recessive p53 mutations compared with controls (P = 0.002).
|
15950766 |
2005 |
|
rs1131691014
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Specifically, we found (i) that the genotype distributions of the P53 Arg72Pro between all brain tumors</span> and controls were statistically significant (P < 0.001) as well as their variant allele frequencies between cases and controls (P < 0.001); (ii) that there was a significant increase in the Arg/Pro heterozygous genotype among high-grade astrocytomas compared with non-astrocytomas (P = 0.002); and (iii) that there was a significant increase in the Arg/Pro heterozygous genotype among high-grade astrocytomas containing transdominant as well as recessive p53 mutations compared with controls (P = 0.002).
|
15950766 |
2005 |
|
rs878854066
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Specifically, we found (i) that the genotype distributions of the P53 Arg72Pro between all brain tumors</span> and controls were statistically significant (P < 0.001) as well as their variant allele frequencies between cases and controls (P < 0.001); (ii) that there was a significant increase in the Arg/Pro heterozygous genotype among high-grade astrocytomas compared with non-astrocytomas (P = 0.002); and (iii) that there was a significant increase in the Arg/Pro heterozygous genotype among high-grade astrocytomas containing transdominant as well as recessive p53 mutations compared with controls (P = 0.002).
|
15950766 |
2005 |
|
rs78378222
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A noncoding polymorphism (rs78378222) in TP53, carried by scores of millions of people, was previously associated with moderate risk of brain tumors and other neoplasms.
|
31699989 |
2019 |
|
rs1800371
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We suggest that TP53 Pro47Ser and Arg72Pro polymorphisms and DNA hypermethylation are involved in susceptibility for developing extra-axial brain tumors.
|
19224462 |
2009 |