|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Furthermore, they provide clinical evidence that HER-2 Ile655Val SNP does affect serum HER-2 levels and it can be regarded as a predictive biomarker for breast cancer patients with poor prognosis.
|
18237248 |
2008 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Studies on the association between the Ile to Val polymorphism at codon 655 of the human epithelial growth factor receptor 2 (HER-2) gene and susceptibility to breast cancer have been reported for almost all ethnic populations, with both positive or negative conclusions.
|
18090908 |
2008 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Furthermore, the opposing effects of the neu* activating oncogenic point mutation and the Val-655-->Ile single-nucleotide polymorphism shown to be linked to reduced risk of breast cancer are explained in terms of shifts in the equilibrium between the active and inactive states of erbB2 in vivo.
|
12461170 |
2002 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A single-nucleotide polymorphism (SNP) at codon 655, resulting in a G-to-A transition (Ile655Val) in the transmembrane domain-coding region of this gene has been associated with an increased risk of breast cancer, particularly among younger women.
|
12166652 |
2002 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The HER2 I655V polymorphism and breast cancer risk in Ashkenazim.
|
14569185 |
2003 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The P53 gene codon 72 Arg/Pro and Her2 gene Ile655Val polymorphisms were not associated with the risk of breast cancer in Turkish women.
|
20380571 |
2010 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this study we aimed to determine whether the risk of breast cancer is associated with the I655V polymorphism of HER2 transmembrane domain-coding region at codon 655.
|
18721072 |
2008 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Genomic DNA from 339 patients with breast cancer and 361 healthy control subjects was examined for the Val(655)Ile polymorphism with a polymerase chain reaction-restriction fragment-length polymorphism-based assay.
|
10699071 |
2000 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In summary, our meta-analysis findings suggest that the HER2 Ile655Val polymorphism is marginally associated with breast cancer susceptibility in worldwide populations with additive and dominant models, but not a recessive model.
|
25520082 |
2014 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We studied the HER2 codon 655 (rs1136201) polymorphism in 80 Austrian patients with BC and 100 healthy volunteers by pyrosequencing and polymerase chain reaction.
|
26504013 |
2015 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
One single-nucleotide polymorphism at codon 655 indicates a guanine-to-adenine substitution (Ile655Val) in the transmembrane domain-coding region of the HER-2/neu gene reported to be associated with increased risk of breast cancer.
|
21204706 |
2011 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Moreover, the coding polymorphism I655V has previously been associated with an increased risk of breast cancer.
|
15743501 |
2005 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The present study was conducted to clarify the diagnostic and prognostic significance of TNF-alpha and its combination with HER-2 Ile655Val SNP in breast cancer.
|
20872355 |
2011 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
It is unlikely that HER2 rs1136201 is a risk factor for breast cancer.
|
21474413 |
2011 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, our meta-analysis suggests that HER2 Ile 655Val polymorphism may contribute to breast cancer risk.
|
20401632 |
2010 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These study results suggest that Ile655Val polymorphism of the ERBB2 gene do not alter its activity and may not be associated with increased breast cancer risk among Chinese women.
|
17687647 |
2008 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We genotyped the Ile655Val single nucleotide polymorphism (rs1801200) in 1271 incident breast cancer cases, and 1667 controls who were selected from the Nurses' Health Study blood cohort.
|
15970791 |
2005 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Although the biological role of the I655V polymorphism is not known, large independent studies of early onset breast cancer are warranted to attempt to replicate this finding.
|
14578152 |
2003 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our study proposes the allelic imbalance of Ile655Val polymorphism between Greek Christian and Greek Muslim populations of Thrace contributes to the inconsistent association between this SNP and breast cancer risk across these two different ethnic groups.
|
17918664 |
2007 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Ile655Val polymorphism of HER-2 gene was associated with a statistically significantly increased risk of breast cancer all above in homozygotes for Val allele.
|
16416013 |
2006 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
HER2 Ile655Val polymorphism affects the function of HER2 gene only restricted in HER2-positive breast cancers.
|
24608202 |
2014 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We studied the HER2 codon 655 (rs1136201) polymorphism in 80 Austrian patients with BC and 100 healthy volunteers by pyrosequencing and polymerase chain reaction.
|
26637882 |
2015 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this analysis, we measured the association between the Ile(655)Val variant and postmenopausal breast cancer among women participating in the Hawaii and Los Angeles Multiethnic Cohort.
|
11731415 |
2001 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Two hundred and four cases and 138 controls were collected to investigate the association of HER-2 Ile655Val polymorphism with the risk of breast cancer development and progression in Iranian population.
|
15374636 |
2004 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Human ERBB2 presents several SNPs.One of these, Ile655Val, introduces a structural change in the transmembrane region of ERBB2 and has been the focus of debate over its potential role as a susceptibility marker for breast cancer risk.
|
17452776 |
2007 |