rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The results suggest that the ABCB1-C3435T gene polymorphism might be a genetic risk factor and a potential biomarker for breast cancer.
|
28039704 |
2017 |
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The present study was aimed to evaluate the possible effects of ABCB1 C3435T and ABCG2 C421A single nucleotide polymorphisms on clinical and pathological outcomes of Kurdish patients with breast cancer.
|
26700668 |
2016 |
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Genetic polymorphisms of MDR1 C3435T and G2677A/T, but not C1236T, are associated with increased risk of breast cancer.
|
26838221 |
2016 |
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We have noted that the implication of C3435T</span> variant on the risk of breast cancer was ethnicity-dependent.
|
27580695 |
2016 |
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We conclude that the T allele carrier of the 34</span>35 C/T polymorphism in the ABCB1 gene in combination with an estrogen receptor-negative status may be an important risk factor for breast cancer development in premenopausal women.
|
25730063 |
2015 |
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
MDR1 C3435T polymorphism in Mexican patients with breast cancer.
|
25062490 |
2014 |
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We aimed to determine the associations of genetic polymorphisms of excision repair cross-complementation group 1 (ERCC1) rs11615, xeroderma pigmentosum group D (XPD/ERCC2) rs13181, X-ray repair cross complementing group 1 (XRCC1) rs25487, XRCC3 rs1799794, and breast cancer susceptibility gene 1 (BRCA1) rs1799966 from the DNA repair pathway and multiple drug resistance 1 (MDR1/ABCB1) rs1045642 with response to chemotherapy and survival of non-small cell lung cancer (NSCLC) in a Chinese population.
|
24933103 |
2014 |
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our results suggest that the MDR1 C3435T polymorphism may contribute to individual susceptibility to breast cancer.
|
24070710 |
2013 |
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These results suggest that C3435T polymorphism and docetaxel exposure are involved in the response to neoadjuvant chemotherapy in breast cancer patients and may be useful to optimize individualized therapy.
|
23666532 |
2013 |
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, there is limited evidence to indicate that the ABCB1 C3435T and rs2214102 G>A polymorphisms are associated with increased risk of breast cancer.
|
20625815 |
2011 |
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To investigate the role of TSER (TYMS), C677T (MTHFR), Arg72Pro (p53) and C3435T (MDR1) gene polymorphisms in breast cancer patients treated with 5-fluorouracil and cyclophosphamide-based neoadjuvant chemotherapy.
|
20638924 |
2010 |
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We examined the relevance of C3435T polymorphism in relation to breast cancer susceptibility, clinical and pathological characteristics of breast carcinoma, the therapeutic response and hematologic toxicities after anthracycline-based chemotherapy.
|
19752884 |
2010 |
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These results suggest that C3435T polymorphism genotyping and menopausal status at the time of diagnosis might be useful when considering chemotherapy regimens including docetaxel in breast cancer patients.
|
20628376 |
2010 |
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We investigated a possible association between MDR1 gene C3435T polymorphism and its expression in Iranian breast cancer patients.
|
20082268 |
2010 |
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our results suggest that C3435T MDR1 polymorphism was not associated with the susceptibility to breast cancer in the population studied.
|
19388849 |
2009 |
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A statistical association was observed between p53 codon 72 polymorphism and family history of breast cancer in both groups, as well as between MDR1 C3435T and smoking habits in cases (P<0.05).Gene polymorphisms vary by regions.
|
19885596 |
2009 |
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We observed difference in SNPs in MDR1 gene C3435T p</span>olymorphism between breast cancer patients and healthy controls (chi(2) = 8.66, df = 2, p = 0.013).
|
17560460 |
2007 |
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We investigated the incidence of C3435T polymorphisms at exon 26 in the MDR-1 gene in 92 women with breast cancer and potential association of altered genotypes with smoking and high body mass index in cancer development among patients.
|
17549370 |
2007 |
rs1128503
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Genetic polymorphisms of MDR1 C3435T and G2677A/T, but not C1236T, are associated with increased risk of breast cancer.
|
26838221 |
2016 |
rs1128503
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In this study, we examined the association between polymorphisms 3435 C/T and 1236 C/T in the ABCB1 gene and breast cancer development in Mexican women according to their menopausal status and molecular classification.
|
25730063 |
2015 |
rs1128503
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Whether ABCB1 polymorphisms including T-129C, A61G, C1236T, G2677T/A and C3435T polymorphisms could account for variations in the disposition of docetaxel and whether menopausal status at the time of diagnosis might interact with this effect were analysed in women receiving neoadjuvant chemotherapy for breast cancer (n=86).
|
20628376 |
2010 |
rs2032582
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The results of our quantitative synthesis suggest that there is no significant association between ABCB1 G2677T/A polymorphism and breast cancer risk in overall comparisons under four genetic models (heterozygote: OR = 1.01, 95% CI = 0.92-1.09, P = 0.90; homozygote: OR = 1.01, 95% CI = 0.65-1.55, P = 0.97; recessive model: OR = 1.06, 95% CI = 0.75-1.50, P = 0.76; and dominant model: OR = 0.98, 95% CI = 0.77-1.24, P = 0.85).
|
31679234 |
2019 |
rs2214102
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, there is limited evidence to indicate that the ABCB1 C3435T and rs2214102 G>A polymorphisms are associated with increased risk of breast cancer.
|
20625815 |
2011 |
rs2032582
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Whether ABCB1 polymorphisms including T-129C, A61G, C1236T, G2677T/A and C3435T polymorphisms could account for variations in the disposition of docetaxel and whether menopausal status at the time of diagnosis might interact with this effect were analysed in women receiving neoadjuvant chemotherapy for breast cancer (n=86).
|
20628376 |
2010 |
rs2214102
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Women homozygous for the major ABCB1_rs2214102_G allele were found to be at a significantly increased breast cancer risk associated with combined estrogen-progestagen therapy [odds ratio (OR) = 1.17, 95% confidence interval (CI) = 1.12-1.23, P (interaction) = 0.022].
|
19672706 |
2010 |