rs1463038513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In the Ashkenazi Jewish population, the I1307K allele is unlikely to increase the risk of ovarian cancer or of cancer in general.
|
9679945 |
1998 |
rs1463038513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In addition, in this family, there appears to be no relationship between the I1307K polymorphism and the presence or absence of cancer.
|
9831355 |
1998 |
rs1463038513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To evaluate the role of I1307K in cancer, we genotyped 5,081 Ashkenazi volunteers in a community survey.
|
9731533 |
1998 |
rs1801155
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To evaluate the role of I1307K in cancer, we genotyped 5,081 Ashkenazi volunteers in a community survey.
|
9731533 |
1998 |
rs1801155
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In addition, in this family, there appears to be no relationship between the I1307K polymorphism and the presence or absence of cancer.
|
9831355 |
1998 |
rs1801155
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In the Ashkenazi Jewish population, the I1307K allele is unlikely to increase the risk of ovarian cancer or of cancer in general.
|
9679945 |
1998 |
rs1322051434
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The approach is demonstrated in two cancer data sets: BRCA1 R841W and APC I1307K.
|
9585599 |
1998 |
rs1463038513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Recently, a germline missense mutation, I1307K, was identified in the adenomatous polyposis coli (APC) gene that was suggested to increase cancer predisposition in Ashkenazi Jews.
|
9869603 |
1999 |
rs1463038513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Inherited colorectal polyposis and cancer risk of the APC I1307K polymorphism.
|
9973276 |
1999 |
rs1463038513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The I1307K APC variant may represent a susceptibility gene for colorectal, or other, cancers in Ashkenazi Jews, and partially explains the higher incidence of colorectal cancer in European Israelis.
|
9869602 |
1999 |
rs1801155
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Recently, a germline missense mutation, I1307K, was identified in the adenomatous polyposis coli (APC) gene that was suggested to increase cancer predisposition in Ashkenazi Jews.
|
9869603 |
1999 |
rs1801155
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The I1307K APC variant may represent a susceptibility gene for colorectal, or other, cancers in Ashkenazi Jews, and partially explains the higher incidence of colorectal cancer in European Israelis.
|
9869602 |
1999 |
rs1801155
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Inherited colorectal polyposis and cancer risk of the APC I1307K polymorphism.
|
9973276 |
1999 |
rs1463038513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There are at least nine major cancer susceptibility syndromes that infer an increased risk for colorectal cancer and/or colorectal polyposis; hereditary nonpolyposis colorectal cancer syndrome, Muir-Torre syndrome, Turcot syndrome, the I1307K polymorphism of the APC gene, familial adenomatous polyposis, attenuated familial adenomatous polyposis, Peutz Jeghers syndrome, juvenile polyposis, and the PTEN hamartoma tumor syndrome.
|
11005140 |
2000 |
rs1463038513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We analyzed sex, age, family history, personal history, and gene test results of patients at increased risk for cancer who sought cancer risk counseling at the Johns Hopkins (JH) CRC Risk Assessment Clinic (n = 91), and those submitting samples to the JH Pathology Molecular Diagnostic Laboratory (n = 256) for APC I1307K testing.
|
10756345 |
2000 |
rs1463038513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The I1307K mutation of the adenopolyposis coli gene (APC), located on chromosome 5q21-q22, is associated with an increased risk of cancer in Ashkenazi Jews.
|
11106824 |
2000 |
rs1463038513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The I1307K mutation represents a novel paradigm for cancer-predisposing genes, as it is associated with moderately increased risk of neoplasia without other associated distinguishing phenotypic features.JAMA.2000;284:857-860
|
10938175 |
2000 |
rs1463038513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The high prevalence of the I1307K allele among BRCA1/2 carriers is not associated with increased cancer risk but seems to be genetically connected because of Jewish ancestry.
|
10901363 |
2000 |
rs1801155
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The I1307K mutation represents a novel paradigm for cancer-predisposing genes, as it is associated with moderately increased risk of neoplasia without other associated distinguishing phenotypic features.JAMA.2000;284:857-860
|
10938175 |
2000 |
rs1801155
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The high prevalence of the I1307K allele among BRCA1/2 carriers is not associated with increased cancer risk but seems to be genetically connected because of Jewish ancestry.
|
10901363 |
2000 |
rs1801155
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We analyzed sex, age, family history, personal history, and gene test results of patients at increased risk for cancer who sought cancer risk counseling at the Johns Hopkins (JH) CRC Risk Assessment Clinic (n = 91), and those submitting samples to the JH Pathology Molecular Diagnostic Laboratory (n = 256) for APC I1307K testing.
|
10756345 |
2000 |
rs1801155
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There are at least nine major cancer susceptibility syndromes that infer an increased risk for colorectal cancer and/or colorectal polyposis; hereditary nonpolyposis colorectal cancer syndrome, Muir-Torre syndrome, Turcot syndrome, the I1307K polymorphism of the APC gene, familial adenomatous polyposis, attenuated familial adenomatous polyposis, Peutz Jeghers syndrome, juvenile polyposis, and the PTEN hamartoma tumor syndrome.
|
11005140 |
2000 |
rs1801155
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The I1307K mutation of the adenopolyposis coli gene (APC), located on chromosome 5q21-q22, is associated with an increased risk of cancer in Ashkenazi Jews.
|
11106824 |
2000 |
rs1463038513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We conclude that early age at diagnosis and family history of cancer cannot be used to predict who is likely to harbour the I1307K APC germline mutation carriers.
|
11720476 |
2001 |
rs1801155
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We conclude that early age at diagnosis and family history of cancer cannot be used to predict who is likely to harbour the I1307K APC germline mutation carriers.
|
11720476 |
2001 |