rs920778
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings imply that rs920778 polymorphism does not affect total cancer presence and the effect on specific cancer types is also weak in the Japanese population.
|
31759985 |
2020 |
rs920778
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our results showed a significant association between HOTAIR rs920778 polymorphism and increased cancer risk under all five genetic models, as well as in Asians subgroup analysis based on ethnicity, digestive and gynecologic cancer group based on cancer type.
|
30941992 |
2019 |
rs920778
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The pooled analyses detected significant associations between the rs920778 polymorphism and increased susceptibility to cancer in recessive, dominant, allelic, homozygous, and heterozygous models.
|
29463216 |
2018 |
rs920778
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our meta-analysis showed that HOTAIR polymorphisms of rs12826786 and rs920778 were correlated with increased cancer risk, while rs7958904, rs4759314, rs874945, and rs1899663 were not.
|
29497311 |
2018 |
rs920778
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our results demonstrate that the HOTAIR rs920778 polymorphism may represent a risk factor for cancer, whereas the rs7958904 polymorphism may play a protective role.
|
27791260 |
2017 |
rs920778
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The pooled data showed that rs920778 polymorphism was significantly associated with an increased cancer risk in all five genetic models in Chinese population.
|
28938673 |
2017 |
rs920778
|
|
|
0.100 |
GeneticVariation |
BEFREE |
HOTAIR SNP rs920778, rs7958904 and rs874945 are susceptible to cancer risk.
|
27965458 |
2017 |
rs920778
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The summary results indicated that HOTAIR rs920778 increased the cancer risk in recessive model (OR = 1.61, 95% CI = 1.08-2.41, Pheterogeneity<0.001).
|
28159929 |
2017 |
rs920778
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The results also suggested that other SNPs were correlated with overall cancer risk, namely, two in HOTAIR (HOX transcript antisense RNA: rs920778C/T and rs7958904 G/C) and two in PRNCR1 (rs1016343C/T and rs16901946 A/G).
|
28342449 |
2017 |
rs920778
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The HOTAIR single nucleotide polymorphisms (SNPs) rs920778 (C > T) and rs12826786 (C > T) present in the intronic enhancer and promoter regions of HOTAIR, respectively, are associated with expression, cancer susceptibility, and patient prognosis in some tumor types.
|
28083786 |
2017 |
rs920778
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Considering the single nucleotide polymorphism (SNP) rs920778 (C>T) could influence HOTAIR expression and cancer predisposition in other malignancies, we herein investigated the association between rs920778 status and cervical cancer susceptibility in a Chinese population.
|
27229487 |
2016 |
rs920778
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, the results indicated that HOTAIR polymorphism rs920778 was more generally associated with c</span>ancer risk, particularly in Asians, while rs4759314 was a risk factor for gastric cancer.
|
27246974 |
2016 |
rs920778
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Overall, no significant associations between the HOTAIR polymorphisms (rs920778, rs4759314 and rs1899663) and cancer risk were observed.
|
27010768 |
2016 |
rs920778
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A naturally occurring functional single nucleotide polymorphism (SNP) rs920,778 (C→T) in the intronic enhancer of HOTAIR gene has been demonstrated to affect HOTAIR expression and cancer susceptibility.
|
25980897 |
2015 |
rs920778
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A common functional single nucleotide polymorphism (SNP) rs920778 (T → C) in the intronic enhancer of the HOTAIR has been reported to influence HOTAIR expression and cancer predisposition, but the association of HOTAIR rs920778 polymorphism with BC susceptibility and clinicopathological features has yet to be investigated.
|
25586347 |
2015 |
rs920778
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Controversial data have emerged on the association between cancer risk and the single-nucleotide polymorphism (SNP, rs920778C>T) in Hox transcript antisense RNA (HOTAIR).
|
26547792 |
2015 |
rs4759314
|
|
|
0.080 |
GeneticVariation |
BEFREE |
However, there is no significant association between SNPs variants and cancer risk under any five genetic models for rs4759314, rs1899663 and rs874945.
|
30941992 |
2019 |
rs4759314
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The results showed that cancer risk was elevated in recessive mutation of rs12826786 (TT vs CC+CT: OR =1.55, 95% CI =1.19, 2.03; TT+CT vs CC: OR =1.23, 95% CI =1.04, 1.46; TT vs CC: OR =1.67, 95% CI =1.24, 2.24; T vs C: OR =1.24, 95% CI =1.09, 1.40) and rs920778 (TT vs CC+CT: OR =1.73, 95% CI =1.30, 2.30; TT+CT vs CC: OR =1.40, 95% CI =1.16, 1.70; TT vs CC: OR =1.83, 95% CI =1.25, 2.68; T vs C: OR =1.37, 95% CI =1.18, 1.59), while the results for polymorphisms of rs7958904, rs4759314, rs874945, and rs1899663 were insignificant.
|
29497311 |
2018 |
rs4759314
|
|
|
0.080 |
GeneticVariation |
BEFREE |
However, no significant association was found between the rs1899663, rs874945, and rs4759314 polymorphisms and susceptibility of cancer.
|
29463216 |
2018 |
rs4759314
|
|
|
0.080 |
GeneticVariation |
BEFREE |
rs920778, rs7958904 and rs874945 but not rs4759314 and rs1899663 loci were significantly related to cancer risk, among of which rs920778 and rs874945 increased and rs7958904 decreased cancer risk, respectively.
|
27965458 |
2017 |
rs4759314
|
|
|
0.080 |
GeneticVariation |
BEFREE |
However, no significant association was identified between the rs874945, rs4759314 and rs1899663 polymorphisms and cancer susceptibility.
|
27791260 |
2017 |
rs4759314
|
|
|
0.080 |
GeneticVariation |
BEFREE |
No significant association was noted between the HOTAIR rs4759314 polymorphism and cancer risk in a Chinese population.
|
27685928 |
2017 |
rs4759314
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Overall, no significant associations between the HOTAIR polymorphisms (rs920778, rs4759314 and rs1899663) and cancer r</span>isk were observed.
|
27010768 |
2016 |
rs4759314
|
|
|
0.080 |
GeneticVariation |
BEFREE |
In conclusion, the results indicated that HOTAIR polymorphism rs920778 was more generally associated with cancer risk, particularly in Asians, while rs4759314 was a risk factor for gastric cancer.
|
27246974 |
2016 |
rs1899663
|
|
|
0.070 |
GeneticVariation |
BEFREE |
The results showed that cancer risk was elevated in recessive mutation of rs12826786 (TT vs CC+CT: OR =1.55, 95% CI =1.19, 2.03; TT+CT vs CC: OR =1.23, 95% CI =1.04, 1.46; TT vs CC: OR =1.67, 95% CI =1.24, 2.24; T vs C: OR =1.24, 95% CI =1.09, 1.40) and rs920778 (TT vs CC+CT: OR =1.73, 95% CI =1.30, 2.30; TT+CT vs CC: OR =1.40, 95% CI =1.16, 1.70; TT vs CC: OR =1.83, 95% CI =1.25, 2.68; T vs C: OR =1.37, 95% CI =1.18, 1.59), while the results for polymorphisms of rs7958904, rs4759314, rs874945, and rs1899663 were insignificant.
|
29497311 |
2018 |