rs121434592
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Conclusion This study provides the first clinical data that AKT1 E17K is a therapeutic target in human cancer.
|
28489509 |
2017 |
rs121434592
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Recently, the E17K mutation in the AKT1 has been associated with multiple human malignancies and leukemia in mice.
|
20440266 |
2010 |
rs121434592
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Recently, a somatic activating mutation in the AKT1 gene (E17K) was identified in several cancer types.
|
19853286 |
2010 |
rs121434592
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Overall, we detected the four AKT1 E17K</span> mutations in the breast cancers (4/93; 4.3%), but none in other cancers.
|
18392055 |
2008 |
rs121434592
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Despite the major role of the AKT/PKB family of proteins in the regulation of many growth and survival mechanisms in the cell, and the increasing evidence suggesting that AKT disruption could play a key role in many human malignancies, no major mutations of AKT genes had been reported, until very recently when Carpten et al reported a novel transforming mutation (E17K) in the pleckstrin homology domain of the AKT1 gene in solid tumours.
|
18665177 |
2008 |
rs2494752
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Furthermore, it was demonstrated that AKT1 rs2494752 GG and C polymorphism was more aggressive than other AKT1 rs2494752 cancer cells.
|
30127980 |
2018 |
rs2494752
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Epidemiologic studies suggested that mutations of the PI3K/PTEN/AKT pathway genes are associated with cancer risk, yet no data are available for PTEN rs701848, PIK3CA rs2699887, and AKT1 rs2494752 polymorphism and breast cancer(BC) risk.
|
28423632 |
2017 |
rs2494752
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In addition, AG genotype and GG/AG genotype of rs2494752 was associated with increased risk of cancer.
|
29259266 |
2017 |
rs2498794
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These data suggest that the rs2498794 polymorphism of the AKT1 gene is associated with a long smoking duration and may be involved in the predisposition to cancer when the smoking duration is short or the cigarettes per day is rate low.
|
26137473 |
2015 |