Gene: PTGS2 ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs5275
rs5275
PTGS2
0.030 GeneticVariation BEFREE However, in the stratified analysis by the type of cancer or ethnicity population, NSAID users homozygous for the major allele (TT) in rs5275 demonstrated significantly decreased cancer risk compared with non-NSAID users in cancer type not involving colorectal adenoma (OR = 0.70, 95% CI = 0.59-0.83) and among the USA population (OR = 0.67, 95% CI = 0.56-0.82). 23967159

2013
dbSNP: rs5275
rs5275
PTGS2
0.030 GeneticVariation BEFREE Functional coding region polymorphisms -1195A>G (rs689466), -765G>C (rs20417), and +8473T>C (rs5275) in the COX-2 gene have recently been shown to be associated with several human cancers but their association with HCC has yet to be investigated. 21042835

2011
dbSNP: rs5275
rs5275
PTGS2
0.030 GeneticVariation BEFREE The COX-2 genotypes for 7 single-nucleotide polymorphisms (rs2745557, rs5277, rs2066826, rs4648261, rs4648262, rs2206593, and rs5275) were determined in 162 pancreatic cancer patients and 170 control subjects without cancer who were matched for age and sex. 21705955

2011
dbSNP: rs20417
rs20417
PTGS2 ; PACERR
0.020 GeneticVariation BEFREE NSAID users homozygous for the major allele (GG) in rs20417 displayed a significantly decreased cancer risk than non-NSAID users among the US population (OR = 0.72, 95% CI = 0.58-0.88). 23967159

2013
dbSNP: rs20417
rs20417
PTGS2 ; PACERR
0.020 GeneticVariation BEFREE Single-nucleotide polymorphisms (-765G/C: rs20417, -1195A/G: rs689466, and -1290A/G: rs689465) in the COX-2 promoter might contribute to differential COX-2 expression and subsequent interindividual variability in susceptibility to cancer. 21848701

2011
dbSNP: rs689466
rs689466
PTGS2 ; PACERR
0.020 GeneticVariation BEFREE Functional coding region polymorphisms -1195A>G (rs689466), -765G>C (rs20417), and +8473T>C (rs5275) in the COX-2 gene have recently been shown to be associated with several human cancers but their association with HCC has yet to be investigated. 21042835

2011
dbSNP: rs689466
rs689466
PTGS2 ; PACERR
0.020 GeneticVariation BEFREE Single-nucleotide polymorphisms (-765G/C: rs20417, -1195A/G: rs689466, and -1290A/G: rs689465) in the COX-2 promoter might contribute to differential COX-2 expression and subsequent interindividual variability in susceptibility to cancer. 21848701

2011
dbSNP: rs689465
rs689465
PTGS2 ; PACERR
0.010 GeneticVariation BEFREE Single-nucleotide polymorphisms (-765G/C: rs20417, -1195A/G: rs689466, and -1290A/G: rs689465) in the COX-2 promoter might contribute to differential COX-2 expression and subsequent interindividual variability in susceptibility to cancer. 21848701

2011