|
rs3804099
|
|
|
0.050 |
GeneticVariation |
BEFREE |
All in all, this meta-analysis revealed that not only -196 to -174del increased the risk of among overall cancers, Caucasians are more likely to get cancer because of rs4696480, while rs3804099 polymorphism could reduce the risk of cancer in some genetic models.
|
31710083 |
2019 |
|
rs3804100
|
|
|
0.050 |
GeneticVariation |
BEFREE |
There is no direct evidence showing that rs5743708, rs3804100 and rs1898830 are related to cancer.
|
31710083 |
2019 |
|
rs3804099
|
|
|
0.050 |
GeneticVariation |
BEFREE |
In conclusion, the Delta22 and rs3804100 polymorphisms in TLR2 are risk factors for cancer susceptibility while the TLR2 rs3804099 dominant genotype is a protective factor, especially in Asians.
|
23581420 |
2013 |
|
rs3804099
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Our meta-analysis identified that elevated cancer risk was statistically associated with -196 to -174 del allele in -196 to -174 del polymorphism (OR=1.63, 95% CI=1.10-2.41 for allele comparison; OR=1.64, 95% CI=1.05-2.57 for dominant model; OR=2.26, 95% CI=1.24-4.12 for recessive model; OR=2.57, 95% CI=1.30-5.08 for DD vs. II and OR=1.53, 95% CI=1.01-2.32 for ID vs. II in codominant model); whereas rs3804099 in TLR-2 was associated with decreased cancer risk.
|
23992203 |
2013 |
|
rs3804099
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The present meta-analysis suggests that TLR2+597T>C (rs3804099), +1350C>T (rs3804100) and Arg753Gln (rs5743708) polymorphisms are not associated with cancer risk.
|
24289592 |
2013 |
|
rs3804100
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The present meta-analysis suggests that TLR2+597T>C (rs3804099), +1350C>T (rs3804100) and Arg753Gln (rs5743708) polymorphisms are not associated with cancer risk.
|
24289592 |
2013 |
|
rs3804100
|
|
|
0.050 |
GeneticVariation |
BEFREE |
TLR2 rs3804100 polymorphism was significantly associated with an elevated cancer risk in overall analysis (CC versus CT, OR=1.70, 95% CI: 1.20-2.42; CC versus CT/TT, OR=1.61, 95% CI: 1.15-2.25).
|
23581420 |
2013 |
|
rs3804100
|
|
|
0.050 |
GeneticVariation |
BEFREE |
To assess the effect of four selected polymorphisms (rs5743708, -196 to -174 del polymorphism, rs3804099, and rs3804100) in TLR-2 on cancer, we conducted a meta-analysis, up to November 2012; 20 case-control studies were available.
|
23992203 |
2013 |
|
rs3804099
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The allele frequencies of two SNPs also showed significant associations with location of cancer (rs3804099, P = 0.046, OR, 0.57, 95% CI, 0.33-0.99 and rs3804100, P = 0.019, OR = 0.52, 95% CI = 0.30-0.90).
|
23166414 |
2012 |
|
rs3804100
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The allele frequencies of two SNPs also showed significant associations with location of cancer (rs3804099, P = 0.046, OR, 0.57, 95% CI, 0.33-0.99 and rs3804100, P = 0.019, OR = 0.52, 95% CI = 0.30-0.90).
|
23166414 |
2012 |
|
rs5743708
|
|
|
0.020 |
GeneticVariation |
BEFREE |
There is no direct evidence showing that rs5743708, rs3804100 and rs1898830 are related to cancer.
|
31710083 |
2019 |
|
rs5743708
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The present meta-analysis suggests that TLR2+597T>C (rs3804099), +1350C>T (rs3804100) and Arg753Gln (rs5743708) polymorphisms are not associated with cancer risk.
|
24289592 |
2013 |
|
rs1898830
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There is no direct evidence showing that rs5743708, rs3804100 and rs1898830 are related to cancer.
|
31710083 |
2019 |
|
rs4696480
|
|
|
0.010 |
GeneticVariation |
BEFREE |
All in all, this meta-analysis revealed that not only -196 to -174del increased the risk of among overall cancers, Caucasians are more likely to get cancer because of rs4696480, while rs3804099 polymorphism could reduce the risk of cancer in some genetic models.
|
31710083 |
2019 |